Research
Developmental neurogenetics
Appointments
- Director, Center for Autism Research and Treatment (CART)
- Professor, Neurology
- Psychiatry and Biobehavioral Sciences
- Co-Director, Center for Neurobehavioral Genetics
- Professor in Residence, Tennenbaum Center for the Biology of Creativity
- Human Genetics
- Member, Bioinformatics GPB Home Area
- Brain Research Institute
- CTSI
- Genetics & Genomics GPB Home Area
- Neuroscience GPB Home Area
- Research Education, Training, and Career Development Program (CTSI-ED)
Appointments
Dr. Geschwind’s laboratory conducts research in three primary areas of neurogenetics:
- autism and language;
- focal neurodegenerative syndromes;
- and the structural/molecular basis of human cognitive specializations.
Utilizing a multi-pronged approach, he studies normal human and animal model brain patterning to diseases in which language and social communication are disrupted, such as autism.
Publications
- Dimas, P, Morabito, S, Rawji, KS, Wang, Q, Krause, FN, Cubillos, J et al.. Dysregulation of transcription networks regulating oligodendrogenesis in age-related decline in CNS remyelination. bioRxiv. 2025; :. doi: 10.1101/2025.11.14.688494. PubMed PMID:41292837 PubMed Central PMC12642603.
- McDiarmid, TA, Page, NF, Chardon, FM, Daza, RM, Chen, GT, Kosicki, M et al.. Large-scale discovery of neural enhancers for cis-regulation therapies. bioRxiv. 2025; :. doi: 10.1101/2025.11.04.686611. PubMed PMID:41278953 PubMed Central PMC12637570.
- Schmitd, LB, Hafner, H, Ward, A, Asghari Adib, E, Biscola, NP, Kohen, R et al.. Deletion of murine Sarm1 results in a microenvironment that delays peripheral nerve regeneration after injury. Sci Transl Med. 2025;17 (819):eadp9155. doi: 10.1126/scitranslmed.adp9155. PubMed PMID:41061042 .
- Zhang, X, Grove, J, Gu, Y, Buus, CK, Nielsen, LK, Neufeld, SAS et al.. Polygenic and developmental profiles of autism differ by age at diagnosis. Nature. 2025;646 (8087):1146-1155. doi: 10.1038/s41586-025-09542-6. PubMed PMID:41034588 PubMed Central PMC12571882.
- Rosenberg, GM, Murray, KA, Sawaya, MR, Jiang, YX, Geschwind, DH, Eisenberg, DS et al.. Genetic and structural aspects of amyloid diseases. Sci Transl Med. 2025;17 (818):eadp3378. doi: 10.1126/scitranslmed.adp3378. PubMed PMID:41032625 .