Research
Developmental neurogenetics
Appointments
- Director, Center for Autism Research and Treatment (CART)
- Professor, Neurology
- Psychiatry and Biobehavioral Sciences
- Co-Director, Center for Neurobehavioral Genetics
- Professor in Residence, Tennenbaum Center for the Biology of Creativity
- Human Genetics
- Member, Bioinformatics GPB Home Area
- Brain Research Institute
- CTSI
- Genetics & Genomics GPB Home Area
- Neuroscience GPB Home Area
- Research Education, Training, and Career Development Program (CTSI-ED)
Appointments
Dr. Geschwind’s laboratory conducts research in three primary areas of neurogenetics:
- autism and language;
- focal neurodegenerative syndromes;
- and the structural/molecular basis of human cognitive specializations.
Utilizing a multi-pronged approach, he studies normal human and animal model brain patterning to diseases in which language and social communication are disrupted, such as autism.
Publications
- Li, X, Shi, Z, Hou, K, Eyring, KW, Liu, C, Heffel, MG et al.. Integration of polygenic risk with single cell methylation data using met-scDRS. Bioinformatics. 2026;42 (10):. doi: 10.1093/bioinformatics/btag751. PubMed PMID:42899409 PubMed Central PMC13693840.
- Qi, L, Bertucci, T, Borden, S, Arduini, BL, Lotz, S, Bowles, KR et al.. Multi-omic profiling of 85 iPSC lines from familial dementia reveals cellular diversity and regulators of organoid development. Neuron. 2026; :. doi: 10.1016/j.neuron.2026.09.022. PubMed PMID:42874591 .
- Wang, X, Sun, Y, Sinha, P, Su, R, Zhang, DY, Park, KH et al.. A standardized patient-derived glioblastoma organoid platform for evaluating radiotherapy efficacy and overcoming resistance. Cell Rep Med. 2026;7 (10):103095. doi: 10.1016/j.xcrm.2026.103095. PubMed PMID:42843344 PubMed Central PMC13710385.
- Gerdes, G, Tozzo, V, Service, SK, Frydman-Gani, C, Diaz-Zuluaga, AM, Valencia-Echeverry, J et al.. A founder population reveals genetic variation with major effect on serious mental illness. medRxiv. 2026; :. doi: 10.64898/2026.09.25.26363706. PubMed PMID:42818201 PubMed Central PMC13622407.
- Weitzman, SA, Orrick, J, Fulton-Howard, B, Renton, AE, Fridrikh, M, McKetney, J et al.. An African ancestry-enriched H1 sub-haplotype challenges MAPT haplotype assignment and reveals distinct tau regulatory programs. Neuron. 2026; :. doi: 10.1016/j.neuron.2026.09.008. PubMed PMID:42810345 .