Research
Molecular and cellular mechanisms underlying neural development
Appointments
- Professor, Human Genetics
- Member, Bioinformatics GPB Home Area
- Brain Research Institute
- Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research
- Gene Regulation GPB Home Area
- Genetics & Genomics GPB Home Area
- JCCC Gene Regulation Program Area
- Neuroscience GPB Home Area
Appointments
His current research focuses on the actions of DNA methylation and chromatin-remodeling in regulating neural gene expression, neuronal function, and stem cell differentiation and reprogramming.
Publications
- Tian, Z, Liu, Q, Lin, HY, Zhu, YR, Ling, L, Sung, TC et al.. Effects of ECM protein-coated surfaces on the generation of retinal pigment epithelium cells differentiated from human pluripotent stem cells. Regen Biomater. 2024;11 :rbae091. doi: 10.1093/rb/rbae091. PubMed PMID:39233867 PubMed Central PMC11374035.
- Chen, J, Jia, Y, Sun, Y, Liu, K, Zhou, C, Liu, C et al.. Global marine microbial diversity and its potential in bioprospecting. Nature. 2024; :. doi: 10.1038/s41586-024-07891-2. PubMed PMID:39232160 .
- Zhao, Y, Zheng, G, Yang, S, Liu, S, Wu, Y, Miao, Y et al.. The plant extract PNS mitigates atherosclerosis via promoting Nrf2-mediated inhibition of ferroptosis through reducing USP2-mediated Keap1 deubiquitination. Br J Pharmacol. 2024; :. doi: 10.1111/bph.17311. PubMed PMID:39228119 .
- Huang, Y, Liu, X, Li, S, Li, C, Wang, HY, Liu, Q et al.. Discovery of an unconventional lamprey lymphocyte lineage highlights divergent features in vertebrate adaptive immune system evolution. Nat Commun. 2024;15 (1):7626. doi: 10.1038/s41467-024-51763-2. PubMed PMID:39227584 PubMed Central PMC11372201.
- Wang, HY, Chen, JY, Li, Y, Zhang, X, Liu, X, Lu, Y et al.. Single-cell RNA sequencing illuminates the ontogeny, conservation and diversification of cartilaginous and bony fish lymphocytes. Nat Commun. 2024;15 (1):7627. doi: 10.1038/s41467-024-51761-4. PubMed PMID:39227568 PubMed Central PMC11372145.