Research
Neurogenetic disorders; neurobehavioral biomarkers of serious mental illness
Appointments
- Professor, Departments of Psychiatry and Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior Brain Research Institute
- Integrative Center for Neurobehavioral Genetics
- Center for Autism Research and Treatment (CART)
- Director, Center for the Assessment and Prevention of Prodromal States (CAPPS)
Biography
Her research aims to understand genetic and neurobiological risk factors for the development of early-onset neuropsychiatric disorders. Dr. Bearden’s work examines these questions through two complementary lines of research:
1) The investigation of early biomarkers that predict disease risk and trajectory in at-risk populations; and
2) Translational approaches to understanding disrupted brain circuitry in highly penetrant genetic subtypes (e.g, 22q11.2 microdeletions)
Publications
- Ku, BS, Hamilton, H, Yuan, Q, Parker, DA, Roach, BJ, Bachman, PM et al.. Neighborhood social fragmentation in relation to impaired mismatch negativity among youth at clinical high risk for psychosis and healthy comparisons. Neuropsychopharmacology. 2025; :. doi: 10.1038/s41386-025-02093-4. PubMed PMID:40175526 .
- Harms, MP, Cho, KK, Anticevic, A, Bolo, NR, Bouix, S, Campbell, D et al.. The MR neuroimaging protocol for the Accelerating Medicines Partnership® Schizophrenia Program. Schizophrenia (Heidelb). 2025;11 (1):52. doi: 10.1038/s41537-025-00581-6. PubMed PMID:40175382 .
- Diomino, A, Yuan, Q, Cadenhead, KS, Addington, J, Bearden, CE, Cannon, TD et al.. The role of childhood social fragmentation and perceived discrimination on maladaptive core schemas later in life among young adults at clinical high risk for psychosis and healthy comparisons. Schizophr Res. 2025;279 :71-78. doi: 10.1016/j.schres.2025.03.023. PubMed PMID:40174486 .
- Allott, K, Yassin, W, Alameda, L, Billah, T, Borders, O, Buccilli, K et al.. Cognitive assessment in the Accelerating Medicines Partnership® Schizophrenia Program: harmonization priorities and strategies in a diverse international sample. Schizophrenia (Heidelb). 2025;11 (1):49. doi: 10.1038/s41537-025-00578-1. PubMed PMID:40128256 PubMed Central PMC11933323.
- Alvino, FG, Gini, S, Minetti, A, Pagani, M, Sastre-Yagüe, D, Barsotti, N et al.. Synaptic-dependent developmental dysconnectivity in 22q11.2 deletion syndrome. Sci Adv. 2025;11 (11):eadq2807. doi: 10.1126/sciadv.adq2807. PubMed PMID:40073125 PubMed Central PMC11900866.