Research
Neurogenetic disorders; neurobehavioral biomarkers of serious mental illness
Appointments
- Professor, Departments of Psychiatry and Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior Brain Research Institute
- Integrative Center for Neurobehavioral Genetics
- Center for Autism Research and Treatment (CART)
- Director, Center for the Assessment and Prevention of Prodromal States (CAPPS)
Biography
Her research aims to understand genetic and neurobiological risk factors for the development of early-onset neuropsychiatric disorders. Dr. Bearden’s work examines these questions through two complementary lines of research:
1) The investigation of early biomarkers that predict disease risk and trajectory in at-risk populations; and
2) Translational approaches to understanding disrupted brain circuitry in highly penetrant genetic subtypes (e.g, 22q11.2 microdeletions)
Publications
- Goldsmith, DR, Yuan, QE, Addington, J, Bearden, CE, Cadenhead, KS, Cannon, TD et al.. The moderating role of lifetime social engagement on the relationship between C-reactive protein and negative symptoms among young adults at clinical high risk for psychosis. Brain Behav Immun. 2025; :. doi: 10.1016/j.bbi.2025.07.023. PubMed PMID:40730261 .
- Kopal, J, Huguet, G, Marotta, J, Aggarwal, S, Osayande, N, Kumar, K et al.. A pattern-learning algorithm associates copy number variations with brain structure and behavioural variables in an adolescent population cohort. Nat Biomed Eng. 2025; :. doi: 10.1038/s41551-025-01454-0. PubMed PMID:40681863 .
- Wang, HR, Liu, ZQ, Nomi, JS, Schleifer, CH, Bearden, CE, Misic, B et al.. Multivariate Resting-State Functional Connectivity Features Linked to Transdiagnostic Psychopathology in Early Psychosis. bioRxiv. 2025; :. doi: 10.1101/2025.06.04.654984. PubMed PMID:40661622 PubMed Central PMC12258889.
- Carrión, RE, John, M, Dorvil, S, Auther, A, McLaughlin, D, Arnovitz, M et al.. Exploring the pathways between early auditory processing, processing speed, social cognition, and negative symptoms on social functioning in individuals at clinical high risk for psychosis: A structural equation modeling approach. Biol Psychiatry. 2025; :. doi: 10.1016/j.biopsych.2025.06.033. PubMed PMID:40633882 .
- Yassin, W, Green, JB, Keshavan, M, Del Re, EC, Addington, J, Bearden, CE et al.. Cognitive subtypes in youth at clinical high risk for psychosis. Psychiatry Clin Neurosci. 2025; :. doi: 10.1111/pcn.13861. PubMed PMID:40600477 .