Golshani, Peyman, M.D., Ph.D.

Research

GABAergic network function in awake behaving mice; GABAergic network dysfunction in models of autism and developmental epilepsy

Appointments

• Associate Professor, Neurology
• Neurologist, West LA VA Medical Center

Biography

The Golshani Lab is focused on understanding how changes in the connectivity and excitability of cortical circuits results in autism and intellectual disability.

We use cutting edge tools, such as in-vivo two-photon calcium imaging, high density silicon probe recordings, and miniaturized microscopes to determine how large groups of identified neurons change their ensemble firing patterns in models of disease during behavior.

By understanding the mechanisms underlying circuit dysfunction, we hope to find new-generation treatments for these conditions.

Publications

1. van Lieshout, ML, Lemmens, JMG, Greijdanus, NG, Wienholts, K, Ubels, S, Talboom, K et al.. Colorectal-vaginal fistula after rectal cancer resection: international comparative cohort study of characteristics and treatment. Br J Surg. 2025;112 (11):. doi: 10.1093/bjs/znaf189. PubMed PMID:41251615 PubMed Central PMC12624856.
2. Wang, Z, Zhao, R, Wagenaar, DA, Espino, D, Sheintuch, L, Benshlomo, O et al.. Author Correction: Kilohertz volumetric imaging of in vivo dynamics using squeezed light field microscopy. Nat Methods. 2025; :. doi: 10.1038/s41592-025-02978-8. PubMed PMID:41238822 .
3. Dorian, CC, Taxidis, J, Buonomano, DV, Golshani, P. Hippocampal sequences represent working memory and implicit timing. Cell Rep. 2025;44 (10):116383. doi: 10.1016/j.celrep.2025.116383. PubMed PMID:41100255 PubMed Central PMC12588557.
4. Wang, Z, Zhao, R, Wagenaar, DA, Espino, D, Sheintuch, L, Benshlomo, O et al.. Kilohertz volumetric imaging of in vivo dynamics using squeezed light field microscopy. Nat Methods. 2025;22 (10):2194-2204. doi: 10.1038/s41592-025-02843-8. PubMed PMID:40987870 .
5. Hintiryan, H, Zhu, M, Zhao, P, Zhang, M, Barry, J, Nanda, S et al.. Neural networks of the mouse visceromotor cortex. Nature. 2025; :. doi: 10.1038/s41586-025-09360-w. PubMed PMID:40866707 .

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