Research
GABAergic network function in awake behaving mice; GABAergic network dysfunction in models of autism and developmental epilepsy
Appointments
- Associate Professor, Neurology
- Neurologist, West LA VA Medical Center
Biography
The Golshani Lab is focused on understanding how changes in the connectivity and excitability of cortical circuits results in autism and intellectual disability.
We use cutting edge tools, such as in-vivo two-photon calcium imaging, high density silicon probe recordings, and miniaturized microscopes to determine how large groups of identified neurons change their ensemble firing patterns in models of disease during behavior.
By understanding the mechanisms underlying circuit dysfunction, we hope to find new-generation treatments for these conditions.
Publications
- Ho, V, Tjondropurnomo, R, Nguyen, J, Balkó, E, Depew, S, Chen, X et al.. Single-Nucleus Transcriptomics Reveals Cell Type-Specific Remodeling and Epilepsy-Associated Microglia. bioRxiv. 2026; :. doi: 10.64898/2026.03.04.709339. PubMed PMID:41867871 PubMed Central PMC13001477.
- Juneau, J, Duret, G, Chu, JP, Madruga, B, Dorian, CC, Rodriguez, AV et al.. MiniFAST: a sensitive and fast miniaturized microscope for in vivo neural recording. Neurophotonics. 2026;13 (Suppl 2):S23203. doi: 10.1117/1.NPh.13.S2.S23203. PubMed PMID:41837229 PubMed Central PMC12988765.
- van Lieshout, ML, Lemmens, JMG, Greijdanus, NG, Wienholts, K, Ubels, S, Talboom, K et al.. Colorectal-vaginal fistula after rectal cancer resection: international comparative cohort study of characteristics and treatment. Br J Surg. 2025;112 (11):. doi: 10.1093/bjs/znaf189. PubMed PMID:41251615 PubMed Central PMC12624856.
- Wang, Z, Zhao, R, Wagenaar, DA, Espino, D, Sheintuch, L, Benshlomo, O et al.. Author Correction: Kilohertz volumetric imaging of in vivo dynamics using squeezed light field microscopy. Nat Methods. 2025;22 (12):2685. doi: 10.1038/s41592-025-02978-8. PubMed PMID:41238822 .
- Dorian, CC, Taxidis, J, Buonomano, DV, Golshani, P. Hippocampal sequences represent working memory and implicit timing. Cell Rep. 2025;44 (10):116383. doi: 10.1016/j.celrep.2025.116383. PubMed PMID:41100255 PubMed Central PMC12588557.