Research
Developmental neuropsychology, electrophysiology and molecular genetics
Appointments
- Associate Professor In-Residence, Psychiatry and Biobehavioral Sciences
- Brain Research Institute
- Member, Child and Adolescent Psychiatry
- Genetics & Genomics GPB Home Area
- Neuroscience GPB Home Area
- Faculty, Center for Neurobehavioral Genetics
Biography
Dr. Loo is principal investigator of two NIH grants examining the genetics of electrophysiological (EEG) measurements in attention-deficit/hyperactivity disorder (ADHD). The goal of this work is to define EEG correlates of cognitive and behavioral functioning and use these as ‘refined phenotypes’ to identify risk genes for psychiatric disorder. The long-term goal of this research is to better understand the neural mechanisms by which genetic polymorphisms produce the cognitive and behavioral phenotypes evident in childhood psychiatric disorders.
Dr. Loo’s lab is also studying cognitive and electrophysiological measures as biomarkers for treatment response in ADHD and Tourette’s Disorder. Through collaborations with other neuroscientists, protocols are being developed for the integration of EEG with cognitive and behavioral assays of inhibition and working memory as treatment outcome measures.
Publications
- Loo, SK, Sica, G, Wang, X, Li, T, Chen, L, Gaither-Davis, A et al.. CASTOR1 phosphorylation predicts poor survival in male patients with KRAS-mutated lung adenocarcinoma. Cell Biosci. 2024;14 (1):127. doi: 10.1186/s13578-024-01307-4. PubMed PMID:39385301 PubMed Central PMC11465729.
- Borroto, MC, Patel, H, Srivastava, S, Swanson, LC, Keren, B, Whalen, S et al.. Cohort Expansion and Genotype-Phenotype Analysis of RAB11A-Associated Neurodevelopmental Disorder. Pediatr Neurol. 2024;160 :45-53. doi: 10.1016/j.pediatrneurol.2024.07.010. PubMed PMID:39181022 .
- Huang, Y, Jay, KL, Yen-Wen Huang, A, Wan, J, Jangam, SV, Chorin, O et al.. Loss-of-function in RBBP5 results in a syndromic neurodevelopmental disorder associated with microcephaly. Genet Med. 2024;26 (11):101218. doi: 10.1016/j.gim.2024.101218. PubMed PMID:39036895 .
- Wang, L, Yang, W, Zhu, JQ, Huang, YF, Zhong, M, Loo, SKF et al.. Sub-chronic toxicity of the active fraction of a modified Huang-Lian-Jie-Du Decoction. Toxicol Rep. 2024;13 :101682. doi: 10.1016/j.toxrep.2024.101682. PubMed PMID:39006370 PubMed Central PMC11245941.
- Leman, TY, Barden, S, Swisher, VS, Joyce, DS, Kaplan, KA, Zeitzer, JM et al.. Sleep insufficiency and bedtime irregularity in children with ADHD: A population-based analysis. Sleep Med. 2024;121 :117-126. doi: 10.1016/j.sleep.2024.06.015. PubMed PMID:38959718 .