Maidment, Nigel T., Ph.D.

Research

Neuropharmacology of drug abuse

Appointments

• Professor, Hatos Center for Neuropharmacology
• Psychiatry and Biobehavioral Sciences
• Member, Neuroscience IDP
• Brain Research Institute
• Center for Neurodegenerative Disease Studies

Biography

Maidment’s research encompasses two main areas:

• the neurochemical basis of motivated behavior with an emphasis on its role in addiction
• the neurochemistry of basal ganglia function and their dysfunction in Parkinson’s disease

His laboratory uses a combination of approaches, from in vivo microdialysis, in vivo voltammetry and biosensors concomitant with behavioral analysis to primary cultures of dopamine neurons, to study the influence of abused drugs on mesotelencephalic dopamine, glutamate and opioid peptide systems in the brain.

Publications

1. Videlock, EJ, Hatami, A, Zhu, C, Kawaguchi, R, Chen, H, Khan, T et al.. Distinct Patterns of Gene Expression Changes in the Colon and Striatum of Young Mice Overexpressing Alpha-Synuclein Support Parkinson's Disease as a Multi-System Process. J Parkinsons Dis. 2023;13 (7):1127-1147. doi: 10.3233/JPD-223568. PubMed PMID:37638450 PubMed Central PMC10657720.
2. Lindberg, I, Shu, Z, Lam, H, Helwig, M, Yucer, N, Laperle, A et al.. The proSAAS Chaperone Provides Neuroprotection and Attenuates Transsynaptic α-Synuclein Spread in Rodent Models of Parkinson's Disease. J Parkinsons Dis. 2022;12 (5):1463-1478. doi: 10.3233/JPD-213053. PubMed PMID:35527562 PubMed Central PMC9731515.
3. McGregor, R, Wu, MF, Holmes, B, Lam, HA, Maidment, NT, Gera, J et al.. Hypocretin/Orexin Interactions with Norepinephrine Contribute to the Opiate Withdrawal Syndrome. J Neurosci. 2022;42 (2):255-263. doi: 10.1523/JNEUROSCI.1557-21.2021. PubMed PMID:34853083 PubMed Central PMC8802943.
4. Marshall, AT, Munson, CN, Maidment, NT, Ostlund, SB. Reward-predictive cues elicit excessive reward seeking in adolescent rats. Dev Cogn Neurosci. 2020;45 :100838. doi: 10.1016/j.dcn.2020.100838. PubMed PMID:32846387 PubMed Central PMC7451619.
5. Wang, B, Wen, X, Cao, Y, Huang, S, Lam, HA, Liu, TL et al.. An implantable multifunctional neural microprobe for simultaneous multi-analyte sensing and chemical delivery. Lab Chip. 2020;20 (8):1390-1397. doi: 10.1039/d0lc00021c. PubMed PMID:32211718 PubMed Central PMC7192313.

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