Research
Molecular and cellular and systems mechanisms of learning and memory
Appointments
- Distinguished Professor– Neurobiology, Psychiatry & Biobehavioral Sciences and Psychology
- Director–Integrative Center for Learning and Memory
- Tennenbaum Center for the Biology of Creativity
- Brain Research Institute
- Molecular, Cellular & Integrative Physiology GPB Home Area
- Neuroscience GPB Home Area
Biography
The Silva laboratory is studying the biology of learning and memory. They are interested in the molecular, cellular and circuit processes that underlie the allocation, encoding and storage of information. To accomplish this they are using a variety of techniques including sophisticated molecular and genetic approaches, optical physiology, optogenetics, in vivo imaging and behavioral analysis.
Silva and colleagues have also studied the impact of these mechanisms in animal models of cognitive disorders, including intellectual disabilities. Based on these mechanistic studies, they have developed treatments for Neurofibromatosis type I and Tuberous Sclerosis, that are currently being tested in clinical trials.
The Silva laboratory is also developing bioinformatic strategies for tracking and planning experiments (researchmaps.org).
Publications
- Peres, LS, Bilhalva, LC, Mello, CBE, Silva, AG, Santos, AP, Valle, SF et al.. What Is Your Diagnosis? Blood Smear From a Mixed-Breed Dog. Vet Clin Pathol. 2026; :. doi: 10.1111/vcp.70111. PubMed PMID:42099195 .
- Azamor, T, Bastard, P, da Silva, AMV, de Almeida Machado, L, Dos Santos Gonçalves, B, Jouanguy, E et al.. Inherited IFNAR1 structural deficiency in severe adverse events following yellow fever vaccination. Clin Immunol. 2026; :110711. doi: 10.1016/j.clim.2026.110711. PubMed PMID:42097348 .
- de Oliveira, HF, Mascarenhas, AG, Stringhini, JH, Leandro, NSM, Cafe, MB, Arnhold, E et al.. Effects of Broiler Breeder Age on Egg Quality, Incubation Performance, and Early Progeny Physiological and Muscle Fiber Development. J Anim Physiol Anim Nutr (Berl). 2026; :. doi: 10.1111/jpn.70071. PubMed PMID:42096600 .
- Block, GA, Bleyer, AJ, Silva, AL, Weiner, DE, Lynn, RI, Yang, Y et al.. Correction to: Safety and Efficacy of Tenapanor for Long-term Serum Phosphate Control in Maintenance Dialysis: A 52-Week Randomized Phase 3 Trial (PHREEDOM). Kidney360. 2026; :. doi: 10.34067/KID.0000001245. PubMed PMID:42096282 .
- Kumar, S, Haber, A, Spruce, C, Duong, D, Seyfried, NT, Bailey, L et al.. PSEN1 mutant marmoset fibroblasts mimic multi-omic signatures of Alzheimer's disease. bioRxiv. 2026; :. doi: 10.64898/2026.04.24.720222. PubMed PMID:42094563 PubMed Central PMC13142354.