Research
Molecular and cellular and systems mechanisms of learning and memory
Appointments
- Distinguished Professor– Neurobiology, Psychiatry & Biobehavioral Sciences and Psychology
- Director–Integrative Center for Learning and Memory
- Tennenbaum Center for the Biology of Creativity
- Brain Research Institute
- Molecular, Cellular & Integrative Physiology GPB Home Area
- Neuroscience GPB Home Area
Biography
The Silva laboratory is studying the biology of learning and memory. They are interested in the molecular, cellular and circuit processes that underlie the allocation, encoding and storage of information. To accomplish this they are using a variety of techniques including sophisticated molecular and genetic approaches, optical physiology, optogenetics, in vivo imaging and behavioral analysis.
Silva and colleagues have also studied the impact of these mechanisms in animal models of cognitive disorders, including intellectual disabilities. Based on these mechanistic studies, they have developed treatments for Neurofibromatosis type I and Tuberous Sclerosis, that are currently being tested in clinical trials.
The Silva laboratory is also developing bioinformatic strategies for tracking and planning experiments (researchmaps.org).
Publications
- Xavier, SP, Victor, A, Galvão, ND, da Silva, AMC. Nomogram predicting overall survival in hospitalized cervical cancer patients in Mato Grosso, Brazil. Discov Oncol. 2025;16 (1):1312. doi: 10.1007/s12672-025-02380-y. PubMed PMID:40646341 .
- Araújo, QMDS, Silva, JRS, de Carvalho, CCN, Lima, PD, Silva, ARST, Jain, S et al.. Spatiotemporal analysis of environmental factors associated with visceral leishmaniasis in northeastern Brazil, 2007-2022. Sci Rep. 2025;15 (1):25186. doi: 10.1038/s41598-025-11366-3. PubMed PMID:40646247 .
- Silva, AJ, Verçosa, N, Lima, LG, Cataldi, M, Salcedo, IL, Resende, MAC et al.. 3D printing of a low-cost videolaryngoscope for tracheal intubation. Sci Rep. 2025;15 (1):25183. doi: 10.1038/s41598-025-10332-3. PubMed PMID:40646065 .
- da Silva, AS, de Sousa Araujo, A, de Sousa Santana, R, do Monte, SJH. Thirteen Novel HLA Class I Alleles Identified in a Brazilian Population Using NGS-Based Typing. HLA. 2025;106 (1):e70306. doi: 10.1111/tan.70306. PubMed PMID:40643043 .
- Silva, AF, Assis, G, Silva, RM, Murawska-Ciałowicz, E, Zurek, G, Carvalho, J et al.. The differential effect of strength, cognitive and aerobic training combinations on cognitive performance and functional abilities in elderly with cognitive decline: The Fit4Alz project. J Prev Alzheimers Dis. 2025; :100267. doi: 10.1016/j.tjpad.2025.100267. PubMed PMID:40640060 .