Research
Molecular and cellular and systems mechanisms of learning and memory
Appointments
- Distinguished Professor– Neurobiology, Psychiatry & Biobehavioral Sciences and Psychology
- Director–Integrative Center for Learning and Memory
- Tennenbaum Center for the Biology of Creativity
- Brain Research Institute
- Molecular, Cellular & Integrative Physiology GPB Home Area
- Neuroscience GPB Home Area
Biography
The Silva laboratory is studying the biology of learning and memory. They are interested in the molecular, cellular and circuit processes that underlie the allocation, encoding and storage of information. To accomplish this they are using a variety of techniques including sophisticated molecular and genetic approaches, optical physiology, optogenetics, in vivo imaging and behavioral analysis.
Silva and colleagues have also studied the impact of these mechanisms in animal models of cognitive disorders, including intellectual disabilities. Based on these mechanistic studies, they have developed treatments for Neurofibromatosis type I and Tuberous Sclerosis, that are currently being tested in clinical trials.
The Silva laboratory is also developing bioinformatic strategies for tracking and planning experiments (researchmaps.org).
Publications
- Leite, F, Silva, AM, Paupério, G, Santos, LL. Is the Parsimonious Eurolung risk model a good predictor for all populations? An external validation study. J Cardiothorac Surg. 2025; :. doi: 10.1186/s13019-025-03661-x. PubMed PMID:41350738 .
- Rios-Peralta, KN, Silva, AJC, Alves-de-Sousa, RJ, Curran, KM, MacManus, DB. A computational study of forward head posture biomechanics. J Mech Behav Biomed Mater. 2025;175 :107288. doi: 10.1016/j.jmbbm.2025.107288. PubMed PMID:41349372 .
- Silva, GHCD, Silva, ASD, Shogor, ALB, Montagner, P, Draszevski, TMR, Rosa, VD et al.. Spraying cooling room with essential oils: effects on milk, behavior and thermal comfort. Trop Anim Health Prod. 2025;57 (9):526. doi: 10.1007/s11250-025-04792-y. PubMed PMID:41348413 .
- Mendes, MC, Martins, EAG, Chernozem, RV, Chernozem, PV, Custódio, CC, Surmenev, RA et al.. Osteogenic Differentiation Triggered by Intracellular Magnetoelectric Stimulation of Core-Shell Nanotransducers under Remotely Applied Magnetic Fields. ACS Nano. 2025; :. doi: 10.1021/acsnano.5c10509. PubMed PMID:41347717 .
- Harding, C, Da Silva, A, Khasriya, R, Khullar, V, Lombardo, R, Malde, S et al.. Is There Adequate Evidence for Intracellular Bacteria Being a Significant Cause of rUTIs and Thereby Justifying Targeted Treatments Such as Bladder Fulguration or Intravesical Therapies? ICI-RS 2025. Neurourol Urodyn. 2025; :. doi: 10.1002/nau.70200. PubMed PMID:41347333 .