Research
Molecular and cellular and systems mechanisms of learning and memory
Appointments
- Distinguished Professor– Neurobiology, Psychiatry & Biobehavioral Sciences and Psychology
- Director–Integrative Center for Learning and Memory
- Tennenbaum Center for the Biology of Creativity
- Brain Research Institute
- Molecular, Cellular & Integrative Physiology GPB Home Area
- Neuroscience GPB Home Area
Biography
The Silva laboratory is studying the biology of learning and memory. They are interested in the molecular, cellular and circuit processes that underlie the allocation, encoding and storage of information. To accomplish this they are using a variety of techniques including sophisticated molecular and genetic approaches, optical physiology, optogenetics, in vivo imaging and behavioral analysis.
Silva and colleagues have also studied the impact of these mechanisms in animal models of cognitive disorders, including intellectual disabilities. Based on these mechanistic studies, they have developed treatments for Neurofibromatosis type I and Tuberous Sclerosis, that are currently being tested in clinical trials.
The Silva laboratory is also developing bioinformatic strategies for tracking and planning experiments (researchmaps.org).
Publications
- Simmons, OM, Aldvén, D, Andreasson, P, Baktoft, H, Calles, O, Diserud, O et al.. Atlantic salmon (Salmo salar L.) kelt rheotaxis and position choice are influenced by flow velocity and turbulence in a regulated river. J Fish Biol. 2026; :. doi: 10.1111/jfb.70356. PubMed PMID:41673984 .
- Reveco, S, Llancalahuen, FM, Caviedes, P, Silva, A, Contreras, J, González, C et al.. CPAP and high-flow nasal oxygen also reduce lung, diaphragm, and accessory muscle injury in experimental self-inflicted lung injury. Sci Rep. 2026; :. doi: 10.1038/s41598-026-39564-7. PubMed PMID:41673105 .
- Silva, AL, Fernandes, D, Marinho, AV, Gonçalves, V, Paiva, L, Silva, J et al.. Side-On Cannulation Angioplasty for Late Left Main Stent Failure After Chimney Stenting in Valve-in-Valve TAVR. JACC Cardiovasc Interv. 2026;19 (3):393-395. doi: 10.1016/j.jcin.2025.12.006. PubMed PMID:41672699 .
- Rossing, P, Hauske, SJ, Canziani, ME, Caramori, ML, Cherney, DZI, Correa-Rotter, R et al.. Cumulative Effects of Vicadrostat and Empagliflozin on Albuminuria in CKD. Am J Kidney Dis. 2026; :. doi: 10.1053/j.ajkd.2025.11.009. PubMed PMID:41672369 .
- da Silva, AMP, de Deus, O, Januário Campos Cardoso, L, Virgilio Ribeiro, F, Froelich Meldola, P, Rodrigues Menezes, I et al.. Efficacy, safety, and ARIA risk of anti-β-amyloid antibodies in early Alzheimer's disease: a systematic review, meta-analysis, and meta-regression. Expert Opin Biol Ther. 2026; :. doi: 10.1080/14712598.2026.2631536. PubMed PMID:41671691 .