Research
Molecular and cellular and systems mechanisms of learning and memory
Appointments
- Distinguished Professor– Neurobiology, Psychiatry & Biobehavioral Sciences and Psychology
- Director–Integrative Center for Learning and Memory
- Tennenbaum Center for the Biology of Creativity
- Brain Research Institute
- Molecular, Cellular & Integrative Physiology GPB Home Area
- Neuroscience GPB Home Area
Biography
The Silva laboratory is studying the biology of learning and memory. They are interested in the molecular, cellular and circuit processes that underlie the allocation, encoding and storage of information. To accomplish this they are using a variety of techniques including sophisticated molecular and genetic approaches, optical physiology, optogenetics, in vivo imaging and behavioral analysis.
Silva and colleagues have also studied the impact of these mechanisms in animal models of cognitive disorders, including intellectual disabilities. Based on these mechanistic studies, they have developed treatments for Neurofibromatosis type I and Tuberous Sclerosis, that are currently being tested in clinical trials.
The Silva laboratory is also developing bioinformatic strategies for tracking and planning experiments (researchmaps.org).
Publications
- Silva, TR, Gonçalves, B, Poínhos, R, Teixeira, VH, Silva, AM. Examining intra- and inter-tester reliability of post-scan dual-energy X-ray absorptiometry regional body composition analysis in athletes. Eur J Clin Nutr. 2026; :. doi: 10.1038/s41430-026-01754-x. PubMed PMID:41998350 .
- Magalhães, LS, Alves, JC, de Lucena Couto Ócea, RA, Debbo, A, Lima Dos Santos, P, Mahalingam, S et al.. Distinct inflammatory biomarkers associated with rheumatological outcomes in chronic chikungunya disease. Sci Rep. 2026; :. doi: 10.1038/s41598-026-35570-x. PubMed PMID:41997930 .
- Dayasiri, K, Gunarathna, G, De Silva, A, Umasankar, N, Sinnarajah, K, Suraweera, N et al.. How are young children treated? Multiprovincial patterns of prescribing for children under 5 in Sri Lanka. BMJ Paediatr Open. 2026;10 (1):. doi: 10.1136/bmjpo-2026-004594. PubMed PMID:41997599 .
- da Silva, AM, Rodrigues, PC, Lamghari, M, Nguyen, HT, Kettunen, J, Mosser, S et al.. High-throughput microfluidic platform for modelling inflammatory responses of human articular chondrocytes under variable fluid shear stress. Lab Chip. 2026; :. doi: 10.1039/d5lc01167a. PubMed PMID:41996266 .
- Sprague, SM, Weiner, DE, Tietjen, DP, Pergola, PE, Fishbane, S, Block, GA et al.. Correction to: Tenapanor as Therapy for Hyperphosphatemia in Maintenance Dialysis Patients: Results from the OPTIMIZE Study. Kidney360. 2026; :. doi: 10.34067/KID.0000001230. PubMed PMID:41996191 .