Research
Molecular and cellular and systems mechanisms of learning and memory
Appointments
- Distinguished Professor– Neurobiology, Psychiatry & Biobehavioral Sciences and Psychology
- Director–Integrative Center for Learning and Memory
- Tennenbaum Center for the Biology of Creativity
- Brain Research Institute
- Molecular, Cellular & Integrative Physiology GPB Home Area
- Neuroscience GPB Home Area
Biography
The Silva laboratory is studying the biology of learning and memory. They are interested in the molecular, cellular and circuit processes that underlie the allocation, encoding and storage of information. To accomplish this they are using a variety of techniques including sophisticated molecular and genetic approaches, optical physiology, optogenetics, in vivo imaging and behavioral analysis.
Silva and colleagues have also studied the impact of these mechanisms in animal models of cognitive disorders, including intellectual disabilities. Based on these mechanistic studies, they have developed treatments for Neurofibromatosis type I and Tuberous Sclerosis, that are currently being tested in clinical trials.
The Silva laboratory is also developing bioinformatic strategies for tracking and planning experiments (researchmaps.org).
Publications
- de Bastos Maximiano, ML, Gonçalves, OR, Ribeiro, FV, Han, ML, de Melo Neto, AP, Andrade Fernandes, JV et al.. Early versus late anticoagulation treatment after acute ischemic stroke with atrial fibrillation: a meta-analysis of randomized controlled trials. Neurol Sci. 2026;47 (3):265. doi: 10.1007/s10072-025-08789-1. PubMed PMID:41697537 .
- do Couto, FB, Yonamine, ES, Magno, FG, Barboza, LE, de Araujo, VM, Silva, ABF et al.. PATIENTS WITH SOFT TISSUE SARCOMA AFTER TREATMENT BY NON ORTHOPEDIC ONCOLOGIC SURGEONS: EPIDEMIOLOGICAL PROFILE, STAGING, AND THERAPEUTIC CHALLENGES. Acta Ortop Bras. 2026;34 (1):e293900. doi: 10.1590/1413-785220263401e293900. PubMed PMID:41696555 PubMed Central PMC12904636.
- de Oliveira, DM, da Silva, AA, Torres, TMN, Cardoso, FL, Figueiredo, LM, Faleiro, TB et al.. ANALYSIS OF INTRINSIC FOOT MUSCLE STRENGTH IN DIABETIC PATIENTS WITH AND WITHOUT DIABETIC PERIPHERAL NEUROPATHY COMPARED WITH HEALTHY CONTROLS. Acta Ortop Bras. 2026;34 (1):e289938. doi: 10.1590/1413-785220263401e289938. PubMed PMID:41696551 PubMed Central PMC12904638.
- Resende, GRC, da Silva, JLB, da Silva, WN, Buso, WHD, Diniz, VSDS, Campos, AFC et al.. Graphitic Carbon Nitride as a Nanostimulant in Basil Microgreens: Insights into Growth, Flavonoid Content, and Water Stress Response. ACS Omega. 2026;11 (5):8107-8116. doi: 10.1021/acsomega.5c10297. PubMed PMID:41696323 PubMed Central PMC12902996.
- Martins, AI, Silva, AG, Pais, J, Rocha, NP. The effectiveness of remote computerized cognitive training for older adults with mild cognitive impairment: A systematic review. Digit Health. 2026;12 :20552076261421682. doi: 10.1177/20552076261421682. PubMed PMID:41696088 PubMed Central PMC12901901.