Research
Molecular and cellular and systems mechanisms of learning and memory
Appointments
- Distinguished Professor– Neurobiology, Psychiatry & Biobehavioral Sciences and Psychology
- Director–Integrative Center for Learning and Memory
- Tennenbaum Center for the Biology of Creativity
- Brain Research Institute
- Molecular, Cellular & Integrative Physiology GPB Home Area
- Neuroscience GPB Home Area
Biography
The Silva laboratory is studying the biology of learning and memory. They are interested in the molecular, cellular and circuit processes that underlie the allocation, encoding and storage of information. To accomplish this they are using a variety of techniques including sophisticated molecular and genetic approaches, optical physiology, optogenetics, in vivo imaging and behavioral analysis.
Silva and colleagues have also studied the impact of these mechanisms in animal models of cognitive disorders, including intellectual disabilities. Based on these mechanistic studies, they have developed treatments for Neurofibromatosis type I and Tuberous Sclerosis, that are currently being tested in clinical trials.
The Silva laboratory is also developing bioinformatic strategies for tracking and planning experiments (researchmaps.org).
Publications
- Silva, AMB, Junot, DO, Antonio, PL, Souza, DN, Caldas, LVE. Analysis of dosimetric characteristics of CaSO4:Mn,Tb phosphors synthesized by four different routes. Appl Radiat Isot. 2025;229 :112381. doi: 10.1016/j.apradiso.2025.112381. PubMed PMID:41418660 .
- Sposito, MCC, Branco, LA, Bianchi, J, Duarte, FO, Godoy, KF, Rodolpho, JMA et al.. The Role of Indexed Left Atrial Volume in Detecting Adverse Outcomes in Patients with Chronic Obstructive Pulmonary Disease: A Cohort Study. Arq Bras Cardiol. 2025;122 (10):e20250131. doi: 10.36660/abc.20250131. PubMed PMID:41417547 .
- Picinato-Pirola, M, Silva, ASCD, Araújo, BMAM, Fukushiro, AP. Phonetic changes, dental occlusion and their relationships in individuals with cleft lip and palate undergoing orthognathic surgery. Codas. 2025;37 (6):e20230139. doi: 10.1590/2317-1782/e20230139pt. PubMed PMID:41417541 .
- Paz, VP, Mantovani, MF, Lorenzini, E, Silva, ÂTMD, Paes, RG, Schmidt, CR et al.. Development and validity of a booklet on myocardial revascularization for patient and caregiver education. Rev Bras Enferm. 2025;78 (suppl 4):e20240446. doi: 10.1590/0034-7167-2024-0446. PubMed PMID:41417325 .
- Dos Santos, MC, da Silva, AMP, da Vitória Santos do Nascimento, M, da Silva, TMS, de Souza Franco, E, de Sousa Maia, MB et al.. The Influence of CBD and THC on Hepatic Enzymes of the Human Cytochrome P450 Complex Family: A Systematic Literature Review. Eur J Drug Metab Pharmacokinet. 2025; :. doi: 10.1007/s13318-025-00978-9. PubMed PMID:41417208 .