Research
Molecular and cellular and systems mechanisms of learning and memory
Appointments
- Distinguished Professor– Neurobiology, Psychiatry & Biobehavioral Sciences and Psychology
- Director–Integrative Center for Learning and Memory
- Tennenbaum Center for the Biology of Creativity
- Brain Research Institute
- Molecular, Cellular & Integrative Physiology GPB Home Area
- Neuroscience GPB Home Area
Biography
The Silva laboratory is studying the biology of learning and memory. They are interested in the molecular, cellular and circuit processes that underlie the allocation, encoding and storage of information. To accomplish this they are using a variety of techniques including sophisticated molecular and genetic approaches, optical physiology, optogenetics, in vivo imaging and behavioral analysis.
Silva and colleagues have also studied the impact of these mechanisms in animal models of cognitive disorders, including intellectual disabilities. Based on these mechanistic studies, they have developed treatments for Neurofibromatosis type I and Tuberous Sclerosis, that are currently being tested in clinical trials.
The Silva laboratory is also developing bioinformatic strategies for tracking and planning experiments (researchmaps.org).
Publications
- da Silva, AMP, de Siqueira Lima, DV Jr, Figueiroa Souza, R, Lopes, VHP, Januario Campos Cardoso, L, Ornelas Pinto, EL et al.. Cannabinoids Treatment for Agitation in Alzheimer's Disease: A Systematic Review and Meta-Analysis With Bayesian and Sequential Trial Analyses. Am J Geriatr Psychiatry. 2026; :. doi: 10.1016/j.jagp.2026.05.016. PubMed PMID:42315374 .
- Mishra, K, Tiwari, AK, K, A, Dadge, SD, Rana, R, Tripathi, S et al.. Mitochondria-targeted delivery of bromocriptine via cerium vanadate nanocarriers for Parkinson's disease. Eur J Pharm Biopharm. 2026; :115151. doi: 10.1016/j.ejpb.2026.115151. PubMed PMID:42315039 .
- Reis, GHM, Silva, AT, Cruz, IS, Pedreira, FRO, Cruvinel, BJDM, Gollino, S et al.. Vertical facial discrepancies in Brazilian children and adolescents are associated with polymorphisms in members of the Wnt gene family. Arch Oral Biol. 2026;189 :106658. doi: 10.1016/j.archoralbio.2026.106658. PubMed PMID:42314243 .
- da Silva, MBC, Arend, RB, Lima, NL, Zatt, DB, da Silva, AH, Nauck, EC et al.. Reassessing the Rinne Test: Importance of a Three-Frequency Tuning Fork Evaluation. OTO Open. 2026;10 (2):e70261. doi: 10.1002/oto2.70261. PubMed PMID:42312241 PubMed Central PMC13270388.
- Schrøder, C, Poncin, W, Oliveira, A, Reychler, G, Cnockaert, P, Audag, N et al.. International consensus on airway clearance techniques for patients hospitalised with acute exacerbations of COPD: a European Delphi study. ERJ Open Res. 2026;12 (3):. doi: 10.1183/23120541.01331-2025. PubMed PMID:42311873 PubMed Central PMC13266421.