Research
Molecular and cellular and systems mechanisms of learning and memory
Appointments
- Distinguished Professor– Neurobiology, Psychiatry & Biobehavioral Sciences and Psychology
- Director–Integrative Center for Learning and Memory
- Tennenbaum Center for the Biology of Creativity
- Brain Research Institute
- Molecular, Cellular & Integrative Physiology GPB Home Area
- Neuroscience GPB Home Area
Biography
The Silva laboratory is studying the biology of learning and memory. They are interested in the molecular, cellular and circuit processes that underlie the allocation, encoding and storage of information. To accomplish this they are using a variety of techniques including sophisticated molecular and genetic approaches, optical physiology, optogenetics, in vivo imaging and behavioral analysis.
Silva and colleagues have also studied the impact of these mechanisms in animal models of cognitive disorders, including intellectual disabilities. Based on these mechanistic studies, they have developed treatments for Neurofibromatosis type I and Tuberous Sclerosis, that are currently being tested in clinical trials.
The Silva laboratory is also developing bioinformatic strategies for tracking and planning experiments (researchmaps.org).
Publications
- Silva, JA, Santos, GGD, Ribeiro, IÍDA, Silva, AMGBD, Barreto, IC, Matos, MA et al.. Histomorphometric Study of Non-critical Bone Defect Repair after Implantation of Magnesium-substituted Hydroxyapatite Microspheres. Rev Bras Ortop (Sao Paulo). 2024;59 (4):e519-e525. doi: 10.1055/s-0044-1787768. PubMed PMID:39239581 PubMed Central PMC11374412.
- Silva, AJE, Verçosa, N, Resende, MAC, Cavalcanti, IL. Comparison of a videolaryngoscope with a 3D-printed angled blade and a direct laryngoscope with a Macintosh blade for rapid sequence tracheal intubation: An observational study. Eur J Anaesthesiol. 2024; :. doi: 10.1097/EJA.0000000000002058. PubMed PMID:39238349 .
- da Hora Passos, R, Barbas, CSV, Silva, JM Jr, Correa, TD, da Silva, AA. The Titans' Challenge: The Cross-influence of Heart-Lung and Cerebral Dynamics in Recruitment Maneuver. Neurocrit Care. 2024; :. doi: 10.1007/s12028-024-02108-w. PubMed PMID:39237848 .
- Siqueira, IB, de Oliveira, YLM, Caron, BO, Schmidt, D, Silva, ARST, Jain, S et al.. Amoebicidal activity of essential oils and essential oil-based microemulsions of Aloysia citrodora Ortega ex Pers., Cymbopogon winterianus Jowitt ex Bor and Ocimum gratissimum L. against Acanthamoeba polyphaga trophozoites. J Appl Microbiol. 2024; :. doi: 10.1093/jambio/lxae232. PubMed PMID:39237458 .
- Marini, E, Stagi, S, Cabras, S, Comandini, O, Ssensamba, JT, Fewtrell, M et al.. Associations of bioelectrical impedance and anthropometric variables among populations and within the full spectrum of malnutrition. Nutrition. 2024;127 :112550. doi: 10.1016/j.nut.2024.112550. PubMed PMID:39236522 .