Research
Studying neural stem cell specification in the developing human cortex and in glioblastoma
Appointments
Assistant Professor, Department of Biological Chemistry
Biography
Dr. Aparna Bhaduri earned a B.S in Biochemistry and Cell Biology and a B.A in Political Science from Rice University in 2010. She completed her doctoral studies at Stanford University in Cancer Biology in 2016, where she focused on epithelial tissue differentiation and neoplasms. She was a postdoctoral scholar at the University of California San Francisco in the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, in the lab of Dr. Arnold Kriegstein where she used single-cell approaches to explore developmental neurobiology and glioblastoma. The Bhaduri Lab opened in 2021 and has been using organoid models of cortical development and brain cancer to understand neural stem cell fate specification. Paired with single-cell characterizations, the lab has used organoids to innovate new approaches to manipulate, model, and measure how human neural stem cells engage in fate specification decisions both in healthy development and in brain cancer. Moving forward, Aparna is excited to continue unraveling the mysteries of the human brain alongside the incredible team of scientists in the lab. In her free time, she enjoys spending time with her husband rock climbing, reading, and puzzling.
Publications
- Morales, A, Korsakova, E, Mansooralavi, N, Ravikumar, A, Rivas, G, Soliman, P et al.. Probing DNA damage in Rett syndrome neurons uncovers a role for MECP2 regulation of PARP1. Stem Cell Reports. 2025; :102645. doi: 10.1016/j.stemcr.2025.102645. PubMed PMID:41005313 .
- Bitar, I, Waggoner, R, Restum, A, Bhaduri, A, Abdullah, R, Khan, AM et al.. Diversity in Neuroradiology: A Decade-Long Review of Gender, Racial, and Ethnic Representation Among Fellows. Acad Radiol. 2025; :. doi: 10.1016/j.acra.2025.08.044. PubMed PMID:40915937 .
- Bhaduri, A, Mehta, K, Sharma, D, Sharma, B, Agarwal, M, Dewan, AK et al.. Comprehensive biobanking to enhance precision medicine in head & neck cancer through systematic sample collection & data integration. Indian J Med Res. 2025;161 (6):601-608. doi: 10.25259/IJMR_2035_2024. PubMed PMID:40878329 .
- Baisiwala, S, Fazzari, E, Li, MX, Martija, A, Azizad, DJ, Sun, L et al.. A Human Tumor-Immune Organoid Model of Glioblastoma. bioRxiv. 2025; :. doi: 10.1101/2025.06.16.660009. PubMed PMID:40667050 PubMed Central PMC12262450.
- Peeters, S, Wu, PB, Haist, B, Armellini, A, Kim, WJ, Chen, Z et al.. Cold atmospheric plasma effectively kills chordoma cells through induction of intracellular reactive oxygen species. Sci Rep. 2025;15 (1):20838. doi: 10.1038/s41598-025-05916-y. PubMed PMID:40594543 PubMed Central PMC12219751.