Research
Neurogenetic disorders; neurobehavioral biomarkers of serious mental illness
Appointments
- Professor, Departments of Psychiatry and Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior Brain Research Institute
- Integrative Center for Neurobehavioral Genetics
- Center for Autism Research and Treatment (CART)
- Director, Center for the Assessment and Prevention of Prodromal States (CAPPS)
Biography
Her research aims to understand genetic and neurobiological risk factors for the development of early-onset neuropsychiatric disorders. Dr. Bearden’s work examines these questions through two complementary lines of research:
1) The investigation of early biomarkers that predict disease risk and trajectory in at-risk populations; and
2) Translational approaches to understanding disrupted brain circuitry in highly penetrant genetic subtypes (e.g, 22q11.2 microdeletions)
Publications
- Service, SK, De La Hoz, JF, Diaz-Zuluaga, AM, Arias, A, Pimplaskar, A, Luu, C et al.. Predicting Diagnostic Conversion From Major Depressive Disorder to Bipolar Disorder: An EHR Based Study From Colombia. Bipolar Disord. 2024; :. doi: 10.1111/bdi.13512. PubMed PMID:39666719 .
- Braun, A, Liu, L, Bearden, CE, Cadenhead, KS, Cornblatt, BA, Keshavan, M et al.. Attention Deficit Hyperactivity Disorder Among Youth at Clinical High Risk of Psychosis. Schizophr Bull Open. 2024;5 (1):sgae028. doi: 10.1093/schizbullopen/sgae028. PubMed PMID:39583590 PubMed Central PMC11584910.
- Hamilton, HK, Roach, BJ, Bachman, PM, Belger, A, Carrión, RE, Duncan, E et al.. Mismatch Negativity as an Index of Auditory Short-Term Plasticity: Associations with Cortisol, Inflammation, and Gray Matter Volume in Youth at Clinical High Risk for Psychosis. Clin EEG Neurosci. 2025;56 (1):46-59. doi: 10.1177/15500594241294035. PubMed PMID:39552576 .
- Ramirez-Diaz, AM, Diaz-Zuluaga, AM, Stroud, RE 2nd, Vreeker, A, Bitta, M, Ivankovic, F et al.. Phenotype harmonization and analysis for The Populations Underrepresented in Mental illness Association Studies (the PUMAS Project). medRxiv. 2024; :. doi: 10.1101/2024.10.02.24314732. PubMed PMID:39502669 PubMed Central PMC11537327.
- Cadenhead, KS, Addington, J, Bearden, CE, Cannon, TD, Cornblatt, BA, Keshavan, M et al.. Protective Factors Predict Resilient Outcomes in Clinical High-Risk Youth with the Highest Individualized Psychosis Risk Scores. Schizophr Bull. 2024; :. doi: 10.1093/schbul/sbae182. PubMed PMID:39488001 .