Research
Neurogenetic disorders; neurobehavioral biomarkers of serious mental illness
Appointments
- Professor, Departments of Psychiatry and Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior Brain Research Institute
- Integrative Center for Neurobehavioral Genetics
- Center for Autism Research and Treatment (CART)
- Director, Center for the Assessment and Prevention of Prodromal States (CAPPS)
Biography
Her research aims to understand genetic and neurobiological risk factors for the development of early-onset neuropsychiatric disorders. Dr. Bearden’s work examines these questions through two complementary lines of research:
1) The investigation of early biomarkers that predict disease risk and trajectory in at-risk populations; and
2) Translational approaches to understanding disrupted brain circuitry in highly penetrant genetic subtypes (e.g, 22q11.2 microdeletions)
Publications
- Deng, W, Chong, B, Addington, J, Bearden, CE, Cadenhead, KS, Cornblatt, BA et al.. Beyond the Descriptive: A Comprehensive, Multi-domain Validation of Symptom Trajectories for Individuals at Clinical High Risk for Psychosis. Biol Psychiatry Cogn Neurosci Neuroimaging. 2024; :. doi: 10.1016/j.bpsc.2024.08.020. PubMed PMID:39260565 .
- Amir, CM, Ghahremani, DG, Chang, SE, Cooper, ZD, Bearden, CE. Altered neurobehavioral reward response predicts psychotic-like experiences in youth exposed to cannabis prenatally. medRxiv. 2024; :. doi: 10.1101/2024.08.23.24312453. PubMed PMID:39228696 PubMed Central PMC11370518.
- Forsyth, JK, Zhu, J, Chavannes, AS, Trevorrow, ZH, Hyat, M, Sievertsen, SA et al.. Fetal Gene Regulatory Gene Deletions are Associated with Poor Cognition and Altered Cortical Morphology in Schizophrenia and Community-Based Samples. medRxiv. 2024; :. doi: 10.1101/2024.08.02.24311302. PubMed PMID:39211869 PubMed Central PMC11361264.
- Yassin, W, Green, J, Keshavan, M, Del Re, EC, Addington, J, Bearden, CE et al.. Cognitive subtypes in youth at clinical high risk for psychosis. medRxiv. 2024; :. doi: 10.1101/2024.08.07.24311240. PubMed PMID:39211862 PubMed Central PMC11361220.
- Cohen, S, Goldsmith, DR, Ning, CS, Addington, J, Bearden, CE, Cadenhead, KS et al.. Sleep disturbance, suicidal ideation and psychosis-risk symptoms in individuals at clinical high risk for psychosis. Psychiatry Res. 2024;341 :116147. doi: 10.1016/j.psychres.2024.116147. PubMed PMID:39197223 .