Intellectual and Developmental Disabilities Research Center

FACULTY

Bearden, Carrie, Ph.D.

Research

Neurogenetic disorders; neurobehavioral biomarkers of serious mental illness

Appointments

  • Professor, Departments of Psychiatry and Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior Brain Research Institute
  • Integrative Center for Neurobehavioral Genetics
  • Center for Autism Research and Treatment (CART)
  • Director, Center for the Assessment and Prevention of Prodromal States (CAPPS)

Biography

Her research aims to understand genetic and neurobiological risk factors for the development of early-onset neuropsychiatric disorders. Dr. Bearden’s work examines these questions through two complementary lines of research:

1) The investigation of early biomarkers that predict disease risk and trajectory in at-risk populations; and

2) Translational approaches to understanding disrupted brain circuitry in highly penetrant genetic subtypes (e.g, 22q11.2 microdeletions)

Publications

  1. Cowan, HR, Williams, TF, Mittal, VA, Addington, J, Bearden, CE, Cadenhead, KS et al.. The Complex Latent Structure of Attenuated Psychotic Symptoms: Hierarchical and Bifactor Models of SIPS Symptoms Replicated in Two Large Samples at Clinical High Risk for Psychosis. Schizophr Bull. 2024; :. doi: 10.1093/schbul/sbae042. PubMed PMID:38728417 .
  2. Cowan, HR, Mittal, VA, Addington, J, Bearden, CE, Cadenhead, KS, Cornblatt, BA et al.. Longitudinal Trajectories of Premorbid Social and Academic Adjustment in Youth at Clinical High Risk for Psychosis: Implications for Conversion. Schizophr Bull. 2024; :. doi: 10.1093/schbul/sbae050. PubMed PMID:38706103 .
  3. Ruiz-Yu, B, Le, TP, Weintraub, MJ, Zinberg, J, Addington, J, O'Brien, MP et al.. Race/ethnicity and socioeconomic status as predictors of outcome following family therapy in youth at clinical high risk for psychosis. Early Interv Psychiatry. 2024; :. doi: 10.1111/eip.13541. PubMed PMID:38676463 .
  4. Supekar, K, de Los Angeles, C, Ryali, S, Kushan, L, Schleifer, C, Repetto, G et al.. Robust and replicable functional brain signatures of 22q11.2 deletion syndrome and associated psychosis: a deep neural network-based multi-cohort study. Mol Psychiatry. 2024; :. doi: 10.1038/s41380-024-02495-8. PubMed PMID:38605171 .
  5. Kopal, J, Kumar, K, Shafighi, K, Saltoun, K, Modenato, C, Moreau, CA et al.. Author Correction: Using rare genetic mutations to revisit structural brain asymmetry. Nat Commun. 2024;15 (1):3098. doi: 10.1038/s41467-024-47545-5. PubMed PMID:38600109 PubMed Central PMC11006936.
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