Research
Neurogenetic disorders; neurobehavioral biomarkers of serious mental illness
Appointments
- Professor, Departments of Psychiatry and Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior Brain Research Institute
- Integrative Center for Neurobehavioral Genetics
- Center for Autism Research and Treatment (CART)
- Director, Center for the Assessment and Prevention of Prodromal States (CAPPS)
Biography
Her research aims to understand genetic and neurobiological risk factors for the development of early-onset neuropsychiatric disorders. Dr. Bearden’s work examines these questions through two complementary lines of research:
1) The investigation of early biomarkers that predict disease risk and trajectory in at-risk populations; and
2) Translational approaches to understanding disrupted brain circuitry in highly penetrant genetic subtypes (e.g, 22q11.2 microdeletions)
Publications
- Bronstein, MV, Kummerfeld, E, Bearden, CE, Cornblatt, BA, Walker, EF, Woods, SW et al.. Delineating empirically plausible causal pathways to suicidality among people at clinical high risk for psychosis. J Psychopathol Clin Sci. 2025; :. doi: 10.1037/abn0000969. PubMed PMID:39913476 .
- Ali, NMH, Chawner, SJRA, Kushan-Wells, L, Bearden, CE, Mulle, JG, Pollak, RM et al.. Comparison of autism domains across thirty rare variant genotypes. EBioMedicine. 2025;112 :105521. doi: 10.1016/j.ebiom.2024.105521. PubMed PMID:39891993 .
- Smucny, J, Cannon, TD, Bearden, CE, Addington, J, Cadenhead, KS, Cornblatt, BA et al.. Predicting conversion to psychosis using machine learning: response to Cannon. Front Psychiatry. 2024;15 :1520173. doi: 10.3389/fpsyt.2024.1520173. PubMed PMID:39882161 PubMed Central PMC11775650.
- Service, SK, De La Hoz, JF, Diaz-Zuluaga, AM, Arias, A, Pimplaskar, A, Luu, C et al.. Predicting Diagnostic Conversion From Major Depressive Disorder to Bipolar Disorder: An EHR Based Study From Colombia. Bipolar Disord. 2024; :. doi: 10.1111/bdi.13512. PubMed PMID:39666719 .
- Braun, A, Liu, L, Bearden, CE, Cadenhead, KS, Cornblatt, BA, Keshavan, M et al.. Attention Deficit Hyperactivity Disorder Among Youth at Clinical High Risk of Psychosis. Schizophr Bull Open. 2024;5 (1):sgae028. doi: 10.1093/schizbullopen/sgae028. PubMed PMID:39583590 PubMed Central PMC11584910.