Research
Neurogenetic disorders; neurobehavioral biomarkers of serious mental illness
Appointments
- Professor, Departments of Psychiatry and Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior Brain Research Institute
- Integrative Center for Neurobehavioral Genetics
- Center for Autism Research and Treatment (CART)
- Director, Center for the Assessment and Prevention of Prodromal States (CAPPS)
Biography
Her research aims to understand genetic and neurobiological risk factors for the development of early-onset neuropsychiatric disorders. Dr. Bearden’s work examines these questions through two complementary lines of research:
1) The investigation of early biomarkers that predict disease risk and trajectory in at-risk populations; and
2) Translational approaches to understanding disrupted brain circuitry in highly penetrant genetic subtypes (e.g, 22q11.2 microdeletions)
Publications
- Addington, J, Liu, L, Chu, M, Jungert, K, Penzel, N, Pasternak, O et al.. Baseline Clinical Characterization of Participants in the Accelerating Medicines Partnership Schizophrenia Program. Schizophr Bull Open. 2025;6 (1):sgaf012. doi: 10.1093/schizbullopen/sgaf012. PubMed PMID:40861307 PubMed Central PMC12377803.
- Addington, J, Shalev, A, Liu, L, Jahraus, C, Chu, M, Farina, E et al.. Sample Ascertainment and Recruitment Sources in the Accelerating Medicines Partnership Schizophrenia Program. Schizophr Bull Open. 2025;6 (1):sgaf013. doi: 10.1093/schizbullopen/sgaf013. PubMed PMID:40861306 PubMed Central PMC12377801.
- O'Hora, KP, Bearden, CE. Toward scalable biomarkers: the promise of sleep wearables in neurodevelopmental research. Neuropsychopharmacology. 2025; :. doi: 10.1038/s41386-025-02185-1. PubMed PMID:40859006 .
- Cadenhead, KS, Kennedy, L, Mirzakhanian, H, Addington, J, Bearden, CE, Cannon, TD et al.. Predictors and Moderators of Long-Term Outcome of Persons at Clinical High Risk for Psychosis: Methods and Preliminary Data. Schizophr Bull. 2025; :. doi: 10.1093/schbul/sbaf133. PubMed PMID:40856400 .
- Mukhtar, H, Zhou, D, Farina, EA, Saxena, A, Cahill, J, Addington, J et al.. Prediction of antipsychotic medication inception in antipsychotic-naive youth at clinical high risk for psychosis. Psychol Med. 2025;55 :e241. doi: 10.1017/S0033291725101372. PubMed PMID:40842369 .