Research
Neurogenetic disorders; neurobehavioral biomarkers of serious mental illness
Appointments
- Professor, Departments of Psychiatry and Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior Brain Research Institute
- Integrative Center for Neurobehavioral Genetics
- Center for Autism Research and Treatment (CART)
- Director, Center for the Assessment and Prevention of Prodromal States (CAPPS)
Biography
Her research aims to understand genetic and neurobiological risk factors for the development of early-onset neuropsychiatric disorders. Dr. Bearden’s work examines these questions through two complementary lines of research:
1) The investigation of early biomarkers that predict disease risk and trajectory in at-risk populations; and
2) Translational approaches to understanding disrupted brain circuitry in highly penetrant genetic subtypes (e.g, 22q11.2 microdeletions)
Publications
- Hamilton, HK, Roach, BJ, Bachman, PM, Belger, A, Carrión, RE, Duncan, E et al.. Mismatch Negativity as an Index of Auditory Short-Term Plasticity: Associations with Cortisol, Inflammation, and Gray Matter Volume in Youth at Clinical High Risk for Psychosis. Clin EEG Neurosci. 2024; :15500594241294035. doi: 10.1177/15500594241294035. PubMed PMID:39552576 .
- Ramirez-Diaz, AM, Diaz-Zuluaga, AM, Stroud, RE 2nd, Vreeker, A, Bitta, M, Ivankovic, F et al.. Phenotype harmonization and analysis for The Populations Underrepresented in Mental illness Association Studies (the PUMAS Project). medRxiv. 2024; :. doi: 10.1101/2024.10.02.24314732. PubMed PMID:39502669 PubMed Central PMC11537327.
- Cadenhead, KS, Addington, J, Bearden, CE, Cannon, TD, Cornblatt, BA, Keshavan, M et al.. Protective Factors Predict Resilient Outcomes in Clinical High-Risk Youth with the Highest Individualized Psychosis Risk Scores. Schizophr Bull. 2024; :. doi: 10.1093/schbul/sbae182. PubMed PMID:39488001 .
- Villalón-Reina, JE, Zhu, AH, Nir, TM, Thomopoulos, SI, Laltoo, E, Kushan, L et al.. Large-scale Normative Modeling of Brain Microstructure. 2023 19th Int Symp Med Inf Process Anal SIPAIM (2023). 2023;2023 :. doi: 10.1109/SIPAIM56729.2023.10373451. PubMed PMID:39479180 PubMed Central PMC11524148.
- Doyle, AE, Bearden, CE, Gur, RE, Ledbetter, DH, Martin, CL, McCoy, TH Jr et al.. Advancing Mental Health Research Through Strategic Integration of Transdiagnostic Dimensions and Genomics. Biol Psychiatry. 2024; :. doi: 10.1016/j.biopsych.2024.10.006. PubMed PMID:39424167 .