Research
Neurogenetic disorders; neurobehavioral biomarkers of serious mental illness
Appointments
- Professor, Departments of Psychiatry and Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior Brain Research Institute
- Integrative Center for Neurobehavioral Genetics
- Center for Autism Research and Treatment (CART)
- Director, Center for the Assessment and Prevention of Prodromal States (CAPPS)
Biography
Her research aims to understand genetic and neurobiological risk factors for the development of early-onset neuropsychiatric disorders. Dr. Bearden’s work examines these questions through two complementary lines of research:
1) The investigation of early biomarkers that predict disease risk and trajectory in at-risk populations; and
2) Translational approaches to understanding disrupted brain circuitry in highly penetrant genetic subtypes (e.g, 22q11.2 microdeletions)
Publications
- Allott, K, Yassin, W, Alameda, L, Billah, T, Borders, O, Buccilli, K et al.. Cognitive assessment in the Accelerating Medicines Partnership® Schizophrenia Program: harmonization priorities and strategies in a diverse international sample. Schizophrenia (Heidelb). 2025;11 (1):49. doi: 10.1038/s41537-025-00578-1. PubMed PMID:40128256 PubMed Central PMC11933323.
- Alvino, FG, Gini, S, Minetti, A, Pagani, M, Sastre-Yagüe, D, Barsotti, N et al.. Synaptic-dependent developmental dysconnectivity in 22q11.2 deletion syndrome. Sci Adv. 2025;11 (11):eadq2807. doi: 10.1126/sciadv.adq2807. PubMed PMID:40073125 PubMed Central PMC11900866.
- Aberizk, K, Sefik, E, Yuan, Q, Cao, H, Addington, JM, Bearden, CE et al.. Relations of temporoparietal connectivity with neighborhood social fragmentation in youth at clinical high-risk for psychosis. Schizophr Res. 2025;277 :151-158. doi: 10.1016/j.schres.2025.02.012. PubMed PMID:40068446 .
- Calderon, V, Gamarra, JM, Ruiz-Yu, B, Denenny, DM, Zinberg, JL, Bearden, CE et al.. Navigating the Maze: Caregiver Perspectives on Pathways to Mental Health Care for U.S. Youth at Clinical High Risk for Psychosis. Early Interv Psychiatry. 2025;19 (3):e70025. doi: 10.1111/eip.70025. PubMed PMID:40050513 .
- Mourgues-Codern, C, Benrimoh, D, Gandhi, J, Farina, EA, Vin, R, Zamorano, T et al.. Emergence and dynamics of delusions and hallucinations across stages in early psychosis. Biol Psychiatry. 2025; :. doi: 10.1016/j.biopsych.2025.02.891. PubMed PMID:40020853 .