Research
Neurogenetic disorders; neurobehavioral biomarkers of serious mental illness
Appointments
- Professor, Departments of Psychiatry and Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior Brain Research Institute
- Integrative Center for Neurobehavioral Genetics
- Center for Autism Research and Treatment (CART)
- Director, Center for the Assessment and Prevention of Prodromal States (CAPPS)
Biography
Her research aims to understand genetic and neurobiological risk factors for the development of early-onset neuropsychiatric disorders. Dr. Bearden’s work examines these questions through two complementary lines of research:
1) The investigation of early biomarkers that predict disease risk and trajectory in at-risk populations; and
2) Translational approaches to understanding disrupted brain circuitry in highly penetrant genetic subtypes (e.g, 22q11.2 microdeletions)
Publications
- Silva, AI, Sønderby, IE, Kirov, G, Abdellaoui, A, Agartz, I, Ames, D et al.. Penetrance of neurodevelopmental copy number variants is associated with variations in cortical morphology. Biol Psychiatry Cogn Neurosci Neuroimaging. 2025; :. doi: 10.1016/j.bpsc.2025.05.010. PubMed PMID:40414598 .
- Perkins, DO, Jeffries, CD, Clark, SR, Upthegrove, R, Wannan, CMJ, Wray, NR et al.. Body fluid biomarkers and psychosis risk in The Accelerating Medicines Partnership® Schizophrenia Program: design considerations. Schizophrenia (Heidelb). 2025;11 (1):78. doi: 10.1038/s41537-025-00610-4. PubMed PMID:40399418 PubMed Central PMC12095529.
- Deng, W, MacNutt, C, Addington, J, Bearden, CE, Cadenhead, KS, Carrión, RE et al.. Trajectories of positive symptoms and suicidality in individuals at clinical high risk for psychosis. J Affect Disord. 2025;384 :208-213. doi: 10.1016/j.jad.2025.05.023. PubMed PMID:40334865 .
- Mason, AJC, Palmer, W, Cao, H, Addington, J, Bearden, CE, Cadenhead, KS et al.. Altered brain activation during memory retrieval mediates the relationship between developmental trauma and psychotic symptom severity. Schizophr Res. 2025;281 :115-121. doi: 10.1016/j.schres.2025.04.034. PubMed PMID:40328092 .
- Kumar, K, Liao, Z, Kopal, J, Moreau, C, Ching, CRK, Modenato, C et al.. Cortical differences across psychiatric disorders and associated common and rare genetic variants. medRxiv. 2025; :. doi: 10.1101/2025.04.16.25325971. PubMed PMID:40321288 PubMed Central PMC12047953.