Research
Generation and repair of neural circuits
Appointments
- Assistant Professor, Brain Research Institute
- Member, Neuroscience GPB Home Area
- Adjunct Assistant Professor, Neurobiology
Appointments
Dr. Butler is focused on determining how neurons translate morphogens, such as the Bone Morphogenetic Protein (BMP) family of growth factors, over time to mediate strikingly different processes in the generation of neural circuits. During the course of these studies, she identified a critical mechanism by which the rate of axon outgrowth is controlled during development.
The Butler laboratory is now examining how this process can be harnessed to accelerate axon growth in a regenerative context to stimulate the repair of neural circuits. The successful implementation of this technology could result in significantly improved recovery times for patients with damaged nervous systems.
Publications
- Pringle, S, Dallimer, M, Goddard, MA, Le Goff, LK, Hart, E, Langdale, SJ et al.. Opportunities and challenges for monitoring terrestrial biodiversity in the robotics age. Nat Ecol Evol. 2025; :. doi: 10.1038/s41559-025-02704-9. PubMed PMID:40404926 .
- Munn, JS, Atzema, CL, Austin, PC, Butler, SJ, Fidler, L, Wang, X et al.. Investigating use of diagnostic codes for post-COVID- 19 condition in Ontario health administrative data. BMC Health Serv Res. 2025;25 (1):694. doi: 10.1186/s12913-025-12751-4. PubMed PMID:40369553 PubMed Central PMC12077028.
- Morrison, CA, Gill, JA, Buchan, C, Robinson, RA, Arizaga, J, Baltà, O et al.. How Do Synchrony in Survival and Productivity Influence Abundance Synchrony in European Landbirds?. Ecol Lett. 2025;28 (5):e70105. doi: 10.1111/ele.70105. PubMed PMID:40358129 PubMed Central PMC12070856.
- Mocanu, EM, Ben-Ishay, Y, Topping, L, Fisher, SR, Hunter, RI, Su, XC et al.. Robustness and Sensitivity of Gd(III)-Gd(III) Double Electron-Electron Resonance (DEER) Measurements: Comparative Study of High-Frequency EPR Spectrometer Designs and Spin Label Variants. Appl Magn Reson. 2025;56 (5):591-611. doi: 10.1007/s00723-024-01741-0. PubMed PMID:40297741 PubMed Central PMC12033185.
- Bodman, SE, Stachelek, P, Rehman, U, Plasser, F, Pal, R, Butler, SJ et al.. A switch-on luminescent europium(iii) probe for selective and time-resolved detection of adenosine diphosphate (ADP). Chem Sci. 2025;16 (13):5602-5612. doi: 10.1039/d4sc07188c. PubMed PMID:40028620 PubMed Central PMC11868914.