Research
Understanding neuronal and synaptic mechanisms underlying the pathophysiology of Huntington’s disease and epilepsy.
Appointments
- Professor of Psychiatry & Biobehavioral Sciences
Biography
Dr. Cepeda’s research focuses on understanding the mechanisms underlying neuronal dysfunction in the basal ganglia and cerebral cortex in neurological disorders including Huntington’s disease in animal models and epilepsy in children with malformations of cortical development.
This work combines electrophysiological and morphological techniques in brain slices.
More recently, his research uses advanced methods to visualize live neurons in freely moving animals with the aid of miniscopes and calcium reporters.
Publications
- Padillo-Ruiz, J, Fresno, C, Suarez, G, Blanco, G, Muñoz-Bellvis, L, Justo, I et al.. Effects of the superior mesenteric artery approach versus the no-touch approach during pancreatoduodenectomy on the mobilization of circulating tumour cells and clusters in pancreatic cancer (CETUPANC): randomized clinical trial. BJS Open. 2024;8 (6):. doi: 10.1093/bjsopen/zrae123. PubMed PMID:39485887 PubMed Central PMC11529789.
- Cepeda, C, Holley, SM, Barry, J, Oikonomou, KD, Yazon, VW, Peng, A et al.. Corticostriatal Maldevelopment in the R6/2 Mouse Model of Juvenile Huntington's Disease. bioRxiv. 2024; :. doi: 10.1101/2024.10.15.618500. PubMed PMID:39464124 PubMed Central PMC11507867.
- Daida, T, Shin, BC, Cepeda, C, Devaskar, SU. Neurodevelopment Is Dependent on Maternal Diet: Placenta and Brain Glucose Transporters GLUT1 and GLUT3. Nutrients. 2024;16 (14):. doi: 10.3390/nu16142363. PubMed PMID:39064806 PubMed Central PMC11279700.
- Le Belle, JE, Condro, M, Cepeda, C, Oikonomou, KD, Tessema, K, Dudley, L et al.. Acute rapamycin treatment reveals novel mechanisms of behavioral, physiological, and functional dysfunction in a maternal inflammation mouse model of autism and sensory over-responsivity. bioRxiv. 2024; :. doi: 10.1101/2024.07.08.602602. PubMed PMID:39026891 PubMed Central PMC11257517.
- Chen, GT, Nair, G, Osorio, AJ, Holley, SM, Ghassemzadeh, K, Gonzalez, J et al.. Enhancer-targeted CRISPR-Activation Rescues Haploinsufficient Autism Susceptibility Genes. bioRxiv. 2024; :. doi: 10.1101/2024.03.13.584921. PubMed PMID:38559217 PubMed Central PMC10980046.