Research
Understanding neuronal and synaptic mechanisms underlying the pathophysiology of Huntington’s disease and epilepsy.
Appointments
- Professor of Psychiatry & Biobehavioral Sciences
Biography
Dr. Cepeda’s research focuses on understanding the mechanisms underlying neuronal dysfunction in the basal ganglia and cerebral cortex in neurological disorders including Huntington’s disease in animal models and epilepsy in children with malformations of cortical development.
This work combines electrophysiological and morphological techniques in brain slices.
More recently, his research uses advanced methods to visualize live neurons in freely moving animals with the aid of miniscopes and calcium reporters.
Publications
- Le Belle, JE, Condro, M, Cepeda, C, Oikonomou, KD, Tessema, K, Dudley, L et al.. Acute rapamycin treatment reveals novel mechanisms of behavioral, physiological, and functional dysfunction in a maternal inflammation mouse model of autism and sensory over-responsivity. bioRxiv. 2024; :. doi: 10.1101/2024.07.08.602602. PubMed PMID:39026891 PubMed Central PMC11257517.
- Chen, GT, Nair, G, Osorio, AJ, Holley, SM, Ghassemzadeh, K, Gonzalez, J et al.. Enhancer-targeted CRISPR-Activation Rescues Haploinsufficient Autism Susceptibility Genes. bioRxiv. 2024; :. doi: 10.1101/2024.03.13.584921. PubMed PMID:38559217 PubMed Central PMC10980046.
- Carpo, N, Tran, V, Biancotti, JC, Cepeda, C, Espinosa-Jeffrey, A. Space Flight Enhances Stress Pathways in Human Neural Stem Cells. Biomolecules. 2024;14 (1):. doi: 10.3390/biom14010065. PubMed PMID:38254665 PubMed Central PMC10813251.
- Ji, N, Baptista, A, Yu, CH, Cepeda, C, Green, F, Greenberg, M et al.. Traffic-related air pollution, chronic stress, and changes in exhaled nitric oxide and lung function among a panel of children with asthma living in an underresourced community. Sci Total Environ. 2024;912 :168984. doi: 10.1016/j.scitotenv.2023.168984. PubMed PMID:38040352 .
- Tran, V, Carpo, N, Shaka, S, Zamudio, J, Choi, S, Cepeda, C et al.. Correction: Tran et al. Delayed Maturation of Oligodendrocyte Progenitors by Microgravity: Implications for Multiple Sclerosis and Space Flight. Life 2022, 12, 797. Life (Basel). 2023;13 (10):. doi: 10.3390/life13102051. PubMed PMID:37895487 PubMed Central PMC10607959.