Cepeda, Carlos, Ph.D.

Research

Understanding neuronal and synaptic mechanisms underlying the pathophysiology of Huntington’s disease and epilepsy.

Appointments

• Professor of Psychiatry & Biobehavioral Sciences

Biography

Dr. Cepeda’s research focuses on understanding the mechanisms underlying neuronal dysfunction in the basal ganglia and cerebral cortex in neurological disorders including Huntington’s disease in animal models and epilepsy in children with malformations of cortical development.

This work combines electrophysiological and morphological techniques in brain slices.

More recently, his research uses advanced methods to visualize live neurons in freely moving animals with the aid of miniscopes and calcium reporters.

Publications

1. Sabino, I, Fernandes, MDC, Antunes, A, Monteny, A, Mendes, B, Caldeira, C et al.. Ergo4Workers: A User-Centred App for Tracking Posture and Workload in Healthcare Professionals. Sensors (Basel). 2025;25 (18):. doi: 10.3390/s25185854. PubMed PMID:41013091 PubMed Central PMC12473953.
2. Hintiryan, H, Zhu, M, Zhao, P, Zhang, M, Barry, J, Nanda, S et al.. Neural networks of the mouse visceromotor cortex. Nature. 2025; :. doi: 10.1038/s41586-025-09360-w. PubMed PMID:40866707 .
3. Cepeda, C, Barry, J, Holley, SM. Abnormal neurodevelopment predisposes to cortical hyperexcitability in Huntington's disease. J Huntingtons Dis. 2025; :18796397251366891. doi: 10.1177/18796397251366891. PubMed PMID:40827083 .
4. Dong, HW, Hintiryan, H, Zhu, M, Zhao, P, Zhang, M, Barry, J et al.. Neural Networks of the Mouse Primary Visceromotor Cortex. Res Sq. 2025; :. doi: 10.21203/rs.3.rs-4125909/v1. PubMed PMID:40343331 PubMed Central PMC12060971.
5. Parievsky, A, Moore, C, Kamdjou, T, Cepeda, C, Meshul, CK, Levine, MS et al.. Corrigendum to "Differential electrophysiological and morphological alterations of thalamostriatal and corticostriatal projections in the R6/2 mouse model of Huntington's disease" [Neurobiology of Disease 108 (2017) Pages 29-44]. Neurobiol Dis. 2025;208 :106860. doi: 10.1016/j.nbd.2025.106860. PubMed PMID:40074566 .

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