Research
Circadian rhythms, neural control of behavior
Appointments
- Professor, Psychiatry and Biobehavioral Sciences
- Member, ACCESS Program: Dept. of Molecular, Cell & Integrative Physiology
- Neuroscience IDP
- Brain Research Institute
- Faculty, Molecular, Cellular, and Integrative Physiology IDP
Appointments
The Colwell laboratory’s research has focused on understanding the mechanisms underlying circadian rhythms in mammals. Dysfunction in the timing of these daily cycles is a key symptom in a number of neurological and psychiatric disorders.
Better understanding of the basic biology of this timing system should result in new therapies to improve the quality of life of these patients and the people who care for them.
Publications
- Cortes, LR, Xiong, L, Vree, AR, Reis, FMCV, Kim, N, Feng, B et al.. Pregnancy damps thermoregulatory rhythms across timescales through neural estrogen signaling in mice. Proc Natl Acad Sci U S A. 2026;123 (39):e2611415123. doi: 10.1073/pnas.2611415123. PubMed PMID:42766745 PubMed Central PMC13624634.
- Block, GD, Colwell, CS. Localizing time: Terry L. Page's contributions to circadian biology. Neurobiol Sleep Circadian Rhythms. 2026;21 :100150. doi: 10.1016/j.nbscr.2026.100150. PubMed PMID:42666894 PubMed Central PMC13524503.
- Villanueva, SAMB, Lee, FY, Hitchcock, ON, Dell'Angelica, EC, Colwell, CS, Ghiani, CA et al.. Histomorphometrical Analyses of the Mouse Suprachiasmatic Nucleus. Bio Protoc. 2026;16 (11):e5704. doi: 10.21769/BioProtoc.5704. PubMed PMID:42305124 PubMed Central PMC13266609.
- Sarver, DC, Maddahi, Y, Colwell, CS, Lusis, AJ. Time-restricted feeding enhances cross-tissue temporal coordination of mitochondrial-associated transcripts. iScience. 2026;29 (6):115957. doi: 10.1016/j.isci.2026.115957. PubMed PMID:42205702 PubMed Central PMC13206650.
- Colwell, CS. Timing the decline: Cellular circadian rhythms and Alzheimer's disease. Proc Natl Acad Sci U S A. 2026;123 (15):e2604049123. doi: 10.1073/pnas.2604049123. PubMed PMID:41941651 PubMed Central PMC13079395.