Research
Circadian rhythms, neural control of behavior
Appointments
- Professor, Psychiatry and Biobehavioral Sciences
- Member, ACCESS Program: Dept. of Molecular, Cell & Integrative Physiology
- Neuroscience IDP
- Brain Research Institute
- Faculty, Molecular, Cellular, and Integrative Physiology IDP
Appointments
The Colwell laboratory’s research has focused on understanding the mechanisms underlying circadian rhythms in mammals. Dysfunction in the timing of these daily cycles is a key symptom in a number of neurological and psychiatric disorders.
Better understanding of the basic biology of this timing system should result in new therapies to improve the quality of life of these patients and the people who care for them.
Publications
- Kolobaric, A, Saleska, J, Hewlings, SJ, Bryant, C, Colwell, CS, D'Adamo, CR et al.. A Randomized, Double-Blind, Placebo-Controlled Trial to Assess the Effectiveness and Safety of Melatonin and Three Formulations of Floraworks Proprietary TruCBN™ for Improving Sleep. Pharmaceuticals (Basel). 2024;17 (8):. doi: 10.3390/ph17080977. PubMed PMID:39204082 PubMed Central PMC11357382.
- Dell'Angelica, D, Singh, K, Colwell, CS, Ghiani, CA. Circadian Interventions in Preclinical Models of Huntington's Disease: A Narrative Review. Biomedicines. 2024;12 (8):. doi: 10.3390/biomedicines12081777. PubMed PMID:39200241 PubMed Central PMC11351982.
- Chiem, E, Zhao, K, Dell'Angelica, D, Ghiani, CA, Paul, KN, Colwell, CS et al.. Scheduled feeding improves sleep in a mouse model of Huntington's disease. Front Neurosci. 2024;18 :1427125. doi: 10.3389/fnins.2024.1427125. PubMed PMID:39161652 PubMed Central PMC11330895.
- Saravanapandian, V, Madani, M, Nichols, I, Vincent, S, Dover, M, Dikeman, D et al.. Sleep EEG signatures in mouse models of 15q11.2-13.1 duplication (Dup15q) syndrome. J Neurodev Disord. 2024;16 (1):39. doi: 10.1186/s11689-024-09556-7. PubMed PMID:39014349 PubMed Central PMC11251350.
- Longcore, T, Villanueva, SAMB, Nguyen-Ngo, K, Ghiani, CA, Harrison, B, Colwell, CS et al.. Relative importance of intensity and spectrum of artificial light at night in disrupting behavior of a nocturnal rodent. J Exp Biol. 2024;227 (14):. doi: 10.1242/jeb.247235. PubMed PMID:38873751 .