Research
Molecular and cellular mechanisms underlying neural development
Appointments
- Professor, Human Genetics
- Member, Bioinformatics GPB Home Area
- Brain Research Institute
- Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research
- Gene Regulation GPB Home Area
- Genetics & Genomics GPB Home Area
- JCCC Gene Regulation Program Area
- Neuroscience GPB Home Area
Appointments
His current research focuses on the actions of DNA methylation and chromatin-remodeling in regulating neural gene expression, neuronal function, and stem cell differentiation and reprogramming.
Publications
- Chen, C, Fan, G, Lin, Y, Zheng, Z, Zhang, X, Zhang, Y et al.. Selenium Myricaria germanica Polysaccharides-based Nanoparticles to Improve Immune Activity. Chem Biodivers. 2025; :e01322. doi: 10.1002/cbdv.202501322. PubMed PMID:41289088 .
- Fan, G, Zha, J, Chen, S, Cang, P, Zhang, Q, Yang, J et al.. Computer-aided design enables repurposing of proprotein convertase subtilisin/kexin type 9 degrader from cholesterol-lowering to colon cancer therapy. Mol Biomed. 2025;6 (1):120. doi: 10.1186/s43556-025-00369-1. PubMed PMID:41288856 .
- Geng, J, Wu, J, Luo, S, Liu, D, Nie, J, Fan, G et al.. Unveiling the landscape of prokaryotic global regulators through deep protein language models. mSystems. 2025; :e0095025. doi: 10.1128/msystems.00950-25. PubMed PMID:41283681 .
- Feng, Y, Jin, W, Li, Z, Fan, G, Zhao, J, Zhu, M et al.. Gallic Acid-Modified Graphene Oxide Nanocomposites Based Photothermal-Chemotherapy Enhancing Melanoma Immunotherapy. Int J Nanomedicine. 2025;20 :13797-13813. doi: 10.2147/IJN.S531001. PubMed PMID:41281251 PubMed Central PMC12631035.
- Zhang, Y, Yang, E, Zhang, X, Shi, Y, Fan, G, Wang, Y et al.. A novel sono-activatable nanoreactor induces precision intratumoral juglone generation and caspase 3/GSDME-mediated pyroptosis for treatment of bladder cancer. J Nanobiotechnology. 2025; :. doi: 10.1186/s12951-025-03855-4. PubMed PMID:41275281 .