Research
Molecular and cellular mechanisms underlying neural development
Appointments
- Professor, Human Genetics
- Member, Bioinformatics GPB Home Area
- Brain Research Institute
- Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research
- Gene Regulation GPB Home Area
- Genetics & Genomics GPB Home Area
- JCCC Gene Regulation Program Area
- Neuroscience GPB Home Area
Appointments
His current research focuses on the actions of DNA methylation and chromatin-remodeling in regulating neural gene expression, neuronal function, and stem cell differentiation and reprogramming.
Publications
- Feng, W, Chang, X, Li, Q, Dong, Z, Jin, G, Huang, J et al.. The bidirectional genetic causality between immunocyte phenotypes and dilated cardiomyopathy: A bidirectional Mendelian randomization study. Medicine (Baltimore). 2026;105 (29):e49691. doi: 10.1097/MD.0000000000049691. PubMed PMID:42470070 .
- Khan, T, Abro, AA, Zulfiqar, U, Alotaibi, MS, Asadullaeva, D, Allaberdiev, R et al.. CRISPR-enabled functional genomics for bolstering plant tolerance to abiotic and biotic stress; a comprehensive review. Funct Integr Genomics. 2026;26 (1):. doi: 10.1007/s10142-026-01965-2. PubMed PMID:42469498 .
- Zhao, X, Wu, T, Wu, S, Chen, Y, Zhang, Y, Chen, J et al.. Deep learning reveals FLAD1-mediated mitochondrial metabolic reprogramming in hypoxic tumors. Cell Rep. 2026;45 (7):117711. doi: 10.1016/j.celrep.2026.117711. PubMed PMID:42467529 .
- Wang, C, Tang, X, Yao, Q, Qi, A, Zheng, J, Huang, X et al.. Decoding SHP2 mutations by computational saturation mutagenesis. J Mol Cell Biol. 2026; :. doi: 10.1093/jmcb/mjag022. PubMed PMID:42466850 .
- Fan, G, Huang, JN, Wang, HJ, Ding, Y, Gao, Y, Tuhexun, T et al.. Phenotypic variation and genetic architecture of seedling salt tolerance in Xinjiang wheat revealed by GWAS and resequencing. Front Plant Sci. 2026;17 :1847734. doi: 10.3389/fpls.2026.1847734. PubMed PMID:42465596 PubMed Central PMC13373106.