Research
Molecular and cellular mechanisms underlying neural development
Appointments
- Professor, Human Genetics
- Member, Bioinformatics GPB Home Area
- Brain Research Institute
- Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research
- Gene Regulation GPB Home Area
- Genetics & Genomics GPB Home Area
- JCCC Gene Regulation Program Area
- Neuroscience GPB Home Area
Appointments
His current research focuses on the actions of DNA methylation and chromatin-remodeling in regulating neural gene expression, neuronal function, and stem cell differentiation and reprogramming.
Publications
- Chen, H, Xu, N, Kam, H, Zhao, C, Chen, Q, Fan, G et al.. A TRPV1 agonist from the transcriptome profiling of Dipsastraea rotumana inhibits neuroinflammation in vivo through the NF-κB and MAPK pathways. Pharmacol Res. 2025; :107837. doi: 10.1016/j.phrs.2025.107837. PubMed PMID:40578722 .
- Wang, K, Zhang, L, Li, Q, Wang, Q, Jiang, Z, Wei, Y et al.. Chemotherapy-associated mutational process signature and genomic alterations associated with outcome in metastatic pancreatic cancer. Clin Transl Oncol. 2025; :. doi: 10.1007/s12094-025-03975-1. PubMed PMID:40571815 .
- Li, Y, Kuang, H, Fan, G, Yang, X. Alpha Ketoglutaric Acid attenuates LPS Induced Inflammatory Response by Inhibiting the PKCε/MAPK/P65 Signaling Pathway and Inhibit Oxidative Stress in Kupffer Cells. Inflammation. 2025; :. doi: 10.1007/s10753-025-02308-2. PubMed PMID:40571784 .
- Fan, G, Wang, Y, Wang, R. Recharging aged-CAR with NAD+ to boost immunotherapy. Trends Cancer. 2025; :. doi: 10.1016/j.trecan.2025.06.009. PubMed PMID:40571557 .
- Cui, M, Hu, D, Wu, Y, Liu, Y, Zhai, D, Zhou, X et al.. Combining the Qualitative and Quantitative Parameters of Dual-layer Detector Spectral Computed Tomography to Predict Intracranial Hemorrhage in Acute Ischemic Stroke Patients After Mechanical Thrombectomy. J Comput Assist Tomogr. 2025; :. doi: 10.1097/RCT.0000000000001780. PubMed PMID:40568949 .