Research
Molecular and cellular mechanisms underlying neural development
Appointments
- Professor, Human Genetics
- Member, Bioinformatics GPB Home Area
- Brain Research Institute
- Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research
- Gene Regulation GPB Home Area
- Genetics & Genomics GPB Home Area
- JCCC Gene Regulation Program Area
- Neuroscience GPB Home Area
Appointments
His current research focuses on the actions of DNA methylation and chromatin-remodeling in regulating neural gene expression, neuronal function, and stem cell differentiation and reprogramming.
Publications
- Chen, L, Jiang, L, Han, X, Zhang, R, Zhao, F, Fan, G et al.. The effectiveness and potential regulatory mechanism of Blumea balsamifera derived extracellular vesicles in promoting burn wound healing. Front Cell Dev Biol. 2026;14 :1756718. doi: 10.3389/fcell.2026.1756718. PubMed PMID:41938535 PubMed Central PMC13044083.
- Zhao, Y, Xia, JH, Wang, R, Ma, XQ, Fan, GW, Liu, ST et al.. Development and validation of a risk prediction model for frailty in middle-aged and old adults with cardiovascular metabolic multimorbidity. Geriatr Nurs. 2026;70 :104039. doi: 10.1016/j.gerinurse.2026.104039. PubMed PMID:41936337 .
- Wu, B, Lee, JH, Foshay, KM, Zhang, L, Fernandes, CJ, Gao, B et al.. Developmental lineage restriction is driven by loss of genome transcriptional potency. Cell Rep. 2026;45 (4):117216. doi: 10.1016/j.celrep.2026.117216. PubMed PMID:41931389 .
- Lu, Y, Xiao, J, Wang, J, Meng, Z, Fan, G, Zheng, J et al.. Cellular sensor DAP5 decodes Betacoronaviral NSP5 to drive virus-induced senescence. Front Immunol. 2026;17 :1768183. doi: 10.3389/fimmu.2026.1768183. PubMed PMID:41924271 PubMed Central PMC13036145.
- Wang, F, Li, Y, Xu, J, Tang, W, Xu, X, Lou, X et al.. DNA Repair Enzyme Regulation Strategy for Enhanced Pancreatic Neuroendocrine Tumor Therapy via Targeting siRNA-Lipid Nanoparticles. ACS Nano. 2026; :. doi: 10.1021/acsnano.5c21452. PubMed PMID:41919978 .