Research
Molecular and cellular mechanisms underlying neural development
Appointments
- Professor, Human Genetics
- Member, Bioinformatics GPB Home Area
- Brain Research Institute
- Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research
- Gene Regulation GPB Home Area
- Genetics & Genomics GPB Home Area
- JCCC Gene Regulation Program Area
- Neuroscience GPB Home Area
Appointments
His current research focuses on the actions of DNA methylation and chromatin-remodeling in regulating neural gene expression, neuronal function, and stem cell differentiation and reprogramming.
Publications
- Li, P, Yang, E, Zhang, X, Shi, Y, Chen, C, Fan, G et al.. TIMP1 Derived from Mesenchymal Stem Cells Promotes Bladder Cancer Progression by Regulating the Formation of VDIMs through the RAP1 Pathway. Int J Biol Sci. 2026;22 (7):3322-3341. doi: 10.7150/ijbs.130720. PubMed PMID:42003907 PubMed Central PMC13085890.
- Ji, X, Huang, Y, Wang, J, Dong, Z, Ni, R, Su, Z et al.. JP2 and JCN Crosstalk Abrogate MURF1-Mediated JCN Ubiquitination and Degradation in Cardiomyocytes. JACC Basic Transl Sci. 2026;11 (5):101534. doi: 10.1016/j.jacbts.2026.101534. PubMed PMID:42000606 .
- Sun, Z, Zhang, X, Zheng, Q, Wu, B, Fan, G, Shi, G et al.. A pig model of human radiation-induced veno-occlusive liver disease reveals ferroptosis as a therapeutic target. Cell Rep Med. 2026; :102745. doi: 10.1016/j.xcrm.2026.102745. PubMed PMID:41997141 .
- Fei, Q, Chang, J, Jiang, T, Guan, G, Liang, Y, Cheng, C et al.. TWEAK-Fn14: a promising target for cardio-cerebrovascular diseases and brain-heart syndrome. Front Immunol. 2025;16 :1710055. doi: 10.3389/fimmu.2025.1710055. PubMed PMID:41994499 PubMed Central PMC13079164.
- Yao, N, Song, H, Fan, G, Tao, C, Xiao, Y, Chen, R et al.. Differential effects of packaging materials on the evolution of volatile and non-volatile compounds in soy sauce during long-term storage. J Sci Food Agric. 2026; :. doi: 10.1002/jsfa.70659. PubMed PMID:41986898 .