Research
Molecular and cellular mechanisms underlying neural development
Appointments
- Professor, Human Genetics
- Member, Bioinformatics GPB Home Area
- Brain Research Institute
- Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research
- Gene Regulation GPB Home Area
- Genetics & Genomics GPB Home Area
- JCCC Gene Regulation Program Area
- Neuroscience GPB Home Area
Appointments
His current research focuses on the actions of DNA methylation and chromatin-remodeling in regulating neural gene expression, neuronal function, and stem cell differentiation and reprogramming.
Publications
- Zhang, H, Luo, X, Li, S, Wang, Y, Gao, Y, Shao, Y et al.. Targeting CDK9 With Harmine Induces Homologous Recombination Deficiency and Synergizes With PARP Inhibitors in Ovarian Cancer. Phytother Res. 2025; :. doi: 10.1002/ptr.70021. PubMed PMID:40629910 .
- Liu, Y, Sun, W, Chen, S, Yin, S, Fan, G. Ultrasound-guided mandibular nerve block combined with superficial cervical plexus nerve block in patients undergoing radical surgery for tongue canceron: a randomized controlled trial. BMC Anesthesiol. 2025;25 (1):340. doi: 10.1186/s12871-025-03219-3. PubMed PMID:40624610 PubMed Central PMC12232652.
- Zhou, H, Bao, Y, Zou, N, Fan, G, Sang, H, Wang, E et al.. Correction: The abnormal audiovisual conflict in Parkinson's disease patients is manifestedin perception rather than response. Sci Rep. 2025;15 (1):24227. doi: 10.1038/s41598-025-09188-4. PubMed PMID:40624222 PubMed Central PMC12234646.
- Lou, X, Shi, Y, Zhao, F, Xu, X, Wang, Y, Qin, Y et al.. Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor-Stroma Ratio and Promote Cancer Progression. Cancer Res. 2025; :OF1-OF15. doi: 10.1158/0008-5472.CAN-24-2528. PubMed PMID:40623046 .
- Guo, Y, Zhang, Q, Li, B, Dai, W, Shen, B, Shen, Z et al.. Biliary YB-1/GLI2 axis facilitates ductular reaction and promotes hepatic stellate cell activation via SPP1/Integrin αvβ1 signaling during liver fibrogenesis. Hepatology. 2025; :. doi: 10.1097/HEP.0000000000001458. PubMed PMID:40622850 .