Geschwind Daniel, M.D., Ph.D.

Research

Developmental neurogenetics

Appointments

• Director, Center for Autism Research and Treatment (CART)
• Professor, Neurology
• Psychiatry and Biobehavioral Sciences
• Co-Director, Center for Neurobehavioral Genetics
• Professor in Residence, Tennenbaum Center for the Biology of Creativity
• Human Genetics
• Member, Bioinformatics GPB Home Area
• Brain Research Institute
• CTSI
• Genetics & Genomics GPB Home Area
• Neuroscience GPB Home Area
• Research Education, Training, and Career Development Program (CTSI-ED)

Appointments

Dr. Geschwind’s laboratory conducts research in three primary areas of neurogenetics:

• autism and language;
• focal neurodegenerative syndromes;
• and the structural/molecular basis of human cognitive specializations.

Utilizing a multi-pronged approach, he studies normal human and animal model brain patterning to diseases in which language and social communication are disrupted, such as autism.

Publications

1. Vuong, CK, Weber, A, Seong, P, Matoba, N, Chen, YJ, Peyer, J et al.. A single-cell multiomic analysis identifies molecular and gene-regulatory mechanisms dysregulated in developing Down syndrome neocortex. Science. 2026;392 (6796):eaea1259. doi: 10.1126/science.aea1259. PubMed PMID:42024758 .
2. Xia, W, Morcom, L, Xu, Z, Lu, IL, Wang, Q, Hoi, KK et al.. Expansion of outer cortical CUX2 neurons requires adaptations for DNA repair. Nature. 2026; :. doi: 10.1038/s41586-026-10290-4. PubMed PMID:41922774 .
3. Haas, R, Margolis, MP, Wei, A, Yamaguchi, TN, Feng, J, Tran, T et al.. Advancing precision health discovery in a genetically diverse health system. Cell. 2026;189 (9):2533-2555.e31. doi: 10.1016/j.cell.2026.03.007. PubMed PMID:41903539 .
4. Contreras, AG, Walters, S, Eissman, JM, Archer, DB, Regelson, AN, Durant, A et al.. Genetic modifiers of APOE-ε4-associated cognitive decline. Nat Commun. 2026;17 (1):. doi: 10.1038/s41467-026-68933-z. PubMed PMID:41720779 PubMed Central PMC13036010.
5. Kumar, M, Schlaffner, CN, Tang, S, Beuvink, MA, Viode, A, Mair, W et al.. Molecular features of human pathological tau distinguish tauopathy-associated dementias. Cell. 2026;189 (3):956-968.e13. doi: 10.1016/j.cell.2025.12.036. PubMed PMID:41616780 PubMed Central PMC13075643.

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