Members

Geschwind Daniel, M.D., Ph.D.

Research

Developmental neurogenetics

Appointments

  • Director, Center for Autism Research and Treatment (CART)
  • Professor, Neurology
  • Psychiatry and Biobehavioral Sciences
  • Co-Director, Center for Neurobehavioral Genetics
  • Professor in Residence, Tennenbaum Center for the Biology of Creativity
  • Human Genetics
  • Member, Bioinformatics GPB Home Area
  • Brain Research Institute
  • CTSI
  • Genetics & Genomics GPB Home Area
  • Neuroscience GPB Home Area
  • Research Education, Training, and Career Development Program (CTSI-ED)

Appointments

Dr. Geschwind’s laboratory conducts research in three primary areas of neurogenetics:

  • autism and language;
  • focal neurodegenerative syndromes;
  • and the structural/molecular basis of human cognitive specializations.

Utilizing a multi-pronged approach, he studies normal human and animal model brain patterning to diseases in which language and social communication are disrupted, such as autism.

Publications

  1. Schmitd, LB, Hafner, H, Ward, A, Asghari Adib, E, Biscola, NP, Kohen, R et al.. Deletion of murine Sarm1 results in a microenvironment that delays peripheral nerve regeneration after injury. Sci Transl Med. 2025;17 (819):eadp9155. doi: 10.1126/scitranslmed.adp9155. PubMed PMID:41061042 .
  2. Zhang, X, Grove, J, Gu, Y, Buus, CK, Nielsen, LK, Neufeld, SAS et al.. Polygenic and developmental profiles of autism differ by age at diagnosis. Nature. 2025; :. doi: 10.1038/s41586-025-09542-6. PubMed PMID:41034588 .
  3. Rosenberg, GM, Murray, KA, Sawaya, MR, Jiang, YX, Geschwind, DH, Eisenberg, DS et al.. Genetic and structural aspects of amyloid diseases. Sci Transl Med. 2025;17 (818):eadp3378. doi: 10.1126/scitranslmed.adp3378. PubMed PMID:41032625 .
  4. Franklin, A, Davies, JP, Clifton, NE, Blake, GET, Bamford, R, Walker, EM et al.. Cell-type-specific DNA methylation dynamics in the prenatal and postnatal human cortex. Cell Genom. 2025; :101010. doi: 10.1016/j.xgen.2025.101010. PubMed PMID:40997811 .
  5. Miller, ZA, Ossenkoppele, R, Graff-Radford, NR, Allen, IE, Shwe, W, Rosenberg, L et al.. Neurodevelopment and neural environment inform Alzheimer's disease age at onset and phenotype. Alzheimers Dement. 2025;21 (9):e70668. doi: 10.1002/alz.70668. PubMed PMID:40959879 PubMed Central PMC12441736.
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