Geschwind Daniel, M.D., Ph.D.

Research

Developmental neurogenetics

Appointments

• Director, Center for Autism Research and Treatment (CART)
• Professor, Neurology
• Psychiatry and Biobehavioral Sciences
• Co-Director, Center for Neurobehavioral Genetics
• Professor in Residence, Tennenbaum Center for the Biology of Creativity
• Human Genetics
• Member, Bioinformatics GPB Home Area
• Brain Research Institute
• CTSI
• Genetics & Genomics GPB Home Area
• Neuroscience GPB Home Area
• Research Education, Training, and Career Development Program (CTSI-ED)

Appointments

Dr. Geschwind’s laboratory conducts research in three primary areas of neurogenetics:

• autism and language;
• focal neurodegenerative syndromes;
• and the structural/molecular basis of human cognitive specializations.

Utilizing a multi-pronged approach, he studies normal human and animal model brain patterning to diseases in which language and social communication are disrupted, such as autism.

Publications

1. Montalbano, S, Krebs, MD, Rosengren, A, Vaez, M, Hellberg, KG, Mortensen, PB et al.. Analysis of exonic deletions in a large population study provides novel insights into NRXN1 pathology. NPJ Genom Med. 2024;9 (1):67. doi: 10.1038/s41525-024-00450-8. PubMed PMID:39695155 PubMed Central PMC11655628.
2. Zhang, T, Li, Y, Pan, L, Sha, J, Bailey, M, Faure-Kumar, E et al.. Brain-wide alterations revealed by spatial transcriptomics and proteomics in COVID-19 infection. Nat Aging. 2024;4 (11):1598-1618. doi: 10.1038/s43587-024-00730-z. PubMed PMID:39543407 .
3. Farrell, K, Humphrey, J, Chang, T, Zhao, Y, Leung, YY, Kuksa, PP et al.. Author Correction: Genetic, transcriptomic, histological, and biochemical analysis of progressive supranuclear palsy implicates glial activation and novel risk genes. Nat Commun. 2024;15 (1):9828. doi: 10.1038/s41467-024-53617-3. PubMed PMID:39537593 PubMed Central PMC11561328.
4. Zhang, F, Fu, Y, Jimenez-Cyrus, D, Zhao, T, Shen, Y, Sun, Y et al.. m⁶A/YTHDF2-mediated mRNA decay targets TGF-β signaling to suppress the quiescence acquisition of early postnatal mouse hippocampal NSCs. Cell Stem Cell. 2024; :. doi: 10.1016/j.stem.2024.10.002. PubMed PMID:39476834 .
5. Kovacs, GG, Katsumata, Y, Wu, X, Aung, KZ, Fardo, DW, Forrest, SL et al.. Amyloid-β predominant Alzheimer's disease neuropathologic change. Brain. 2024; :. doi: 10.1093/brain/awae325. PubMed PMID:39417691 .

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