Research
Developmental neurogenetics
Appointments
- Director, Center for Autism Research and Treatment (CART)
- Professor, Neurology
- Psychiatry and Biobehavioral Sciences
- Co-Director, Center for Neurobehavioral Genetics
- Professor in Residence, Tennenbaum Center for the Biology of Creativity
- Human Genetics
- Member, Bioinformatics GPB Home Area
- Brain Research Institute
- CTSI
- Genetics & Genomics GPB Home Area
- Neuroscience GPB Home Area
- Research Education, Training, and Career Development Program (CTSI-ED)
Appointments
Dr. Geschwind’s laboratory conducts research in three primary areas of neurogenetics:
- autism and language;
- focal neurodegenerative syndromes;
- and the structural/molecular basis of human cognitive specializations.
Utilizing a multi-pronged approach, he studies normal human and animal model brain patterning to diseases in which language and social communication are disrupted, such as autism.
Publications
- Rexach, JE, Cheng, Y, Chen, L, Polioudakis, D, Lin, LC, Mitri, V et al.. Cross-disorder and disease-specific pathways in dementia revealed by single-cell genomics. Cell. 2024; :. doi: 10.1016/j.cell.2024.08.019. PubMed PMID:39265576 .
- Farrell, K, Humphrey, J, Chang, T, Zhao, Y, Leung, YY, Kuksa, PP et al.. Genetic, transcriptomic, histological, and biochemical analysis of progressive supranuclear palsy implicates glial activation and novel risk genes. Nat Commun. 2024;15 (1):7880. doi: 10.1038/s41467-024-52025-x. PubMed PMID:39251599 PubMed Central PMC11385559.
- Wang, H, Chang, TS, Dombroski, BA, Cheng, PL, Patil, V, Valiente-Banuet, L et al.. Whole-genome sequencing analysis reveals new susceptibility loci and structural variants associated with progressive supranuclear palsy. Mol Neurodegener. 2024;19 (1):61. doi: 10.1186/s13024-024-00747-3. PubMed PMID:39152475 PubMed Central PMC11330058.
- Zhang, X, Grove, J, Gu, Y, Buus, CK, Nielsen, LK, Neufeld, SAS et al.. An axis of genetic heterogeneity in autism is indexed by age at diagnosis and is associated with varying developmental and mental health profiles. medRxiv. 2024; :. doi: 10.1101/2024.07.31.24311279. PubMed PMID:39132493 PubMed Central PMC11312648.
- Kosmicki, JA, Marcketta, A, Sharma, D, Di Gioia, SA, Batista, S, Yang, XM et al.. Genetic risk factors for COVID-19 and influenza are largely distinct. Nat Genet. 2024;56 (8):1592-1596. doi: 10.1038/s41588-024-01844-1. PubMed PMID:39103650 PubMed Central PMC11319199.