Geschwind Daniel, M.D., Ph.D.

Research

Developmental neurogenetics

Appointments

• Director, Center for Autism Research and Treatment (CART)
• Professor, Neurology
• Psychiatry and Biobehavioral Sciences
• Co-Director, Center for Neurobehavioral Genetics
• Professor in Residence, Tennenbaum Center for the Biology of Creativity
• Human Genetics
• Member, Bioinformatics GPB Home Area
• Brain Research Institute
• CTSI
• Genetics & Genomics GPB Home Area
• Neuroscience GPB Home Area
• Research Education, Training, and Career Development Program (CTSI-ED)

Appointments

Dr. Geschwind’s laboratory conducts research in three primary areas of neurogenetics:

• autism and language;
• focal neurodegenerative syndromes;
• and the structural/molecular basis of human cognitive specializations.

Utilizing a multi-pronged approach, he studies normal human and animal model brain patterning to diseases in which language and social communication are disrupted, such as autism.

Publications

1. Vargas-Gonzalez, JC, Dimal, N, Cortez, K, Heuer, H, Forsberg, LK, Appleby, BS et al.. Psychotropic medication usage in sporadic versus genetic behavioral-variant frontotemporal dementia. Alzheimers Dement. 2024; :. doi: 10.1002/alz.14448. PubMed PMID:39713899 .
2. Montalbano, S, Krebs, MD, Rosengren, A, Vaez, M, Hellberg, KG, Mortensen, PB et al.. Analysis of exonic deletions in a large population study provides novel insights into NRXN1 pathology. NPJ Genom Med. 2024;9 (1):67. doi: 10.1038/s41525-024-00450-8. PubMed PMID:39695155 PubMed Central PMC11655628.
3. Zhang, T, Li, Y, Pan, L, Sha, J, Bailey, M, Faure-Kumar, E et al.. Brain-wide alterations revealed by spatial transcriptomics and proteomics in COVID-19 infection. Nat Aging. 2024;4 (11):1598-1618. doi: 10.1038/s43587-024-00730-z. PubMed PMID:39543407 .
4. Farrell, K, Humphrey, J, Chang, T, Zhao, Y, Leung, YY, Kuksa, PP et al.. Author Correction: Genetic, transcriptomic, histological, and biochemical analysis of progressive supranuclear palsy implicates glial activation and novel risk genes. Nat Commun. 2024;15 (1):9828. doi: 10.1038/s41467-024-53617-3. PubMed PMID:39537593 PubMed Central PMC11561328.
5. Zhang, F, Fu, Y, Jimenez-Cyrus, D, Zhao, T, Shen, Y, Sun, Y et al.. m⁶A/YTHDF2-mediated mRNA decay targets TGF-β signaling to suppress the quiescence acquisition of early postnatal mouse hippocampal NSCs. Cell Stem Cell. 2025;32 (1):144-156.e8. doi: 10.1016/j.stem.2024.10.002. PubMed PMID:39476834 PubMed Central PMC11698649.

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