Research
Developmental neurogenetics
Appointments
- Director, Center for Autism Research and Treatment (CART)
- Professor, Neurology
- Psychiatry and Biobehavioral Sciences
- Co-Director, Center for Neurobehavioral Genetics
- Professor in Residence, Tennenbaum Center for the Biology of Creativity
- Human Genetics
- Member, Bioinformatics GPB Home Area
- Brain Research Institute
- CTSI
- Genetics & Genomics GPB Home Area
- Neuroscience GPB Home Area
- Research Education, Training, and Career Development Program (CTSI-ED)
Appointments
Dr. Geschwind’s laboratory conducts research in three primary areas of neurogenetics:
- autism and language;
- focal neurodegenerative syndromes;
- and the structural/molecular basis of human cognitive specializations.
Utilizing a multi-pronged approach, he studies normal human and animal model brain patterning to diseases in which language and social communication are disrupted, such as autism.
Publications
- Kumar, M, Schlaffner, CN, Tang, S, Beuvink, MA, Viode, A, Mair, W et al.. Molecular features of human pathological tau distinguish tauopathy-associated dementias. Cell. 2026;189 (3):956-968.e13. doi: 10.1016/j.cell.2025.12.036. PubMed PMID:41616780 .
- Gordon, A, Yoon, SJ, Bicks, LK, Martín, JM, Pintacuda, G, Arteaga, S et al.. Developmental convergence and divergence in human stem cell models of autism. Nature. 2026; :. doi: 10.1038/s41586-025-10047-5. PubMed PMID:41611887 .
- Roussos, P, Vaccarino, FM, Weng, Z, Sestan, N, Gerstein, M, Geschwind, DH et al.. PsychENCODE at 10: From genomic maps to mechanistic insights in mental illness. Neuron. 2025;113 (24):4099-4102. doi: 10.1016/j.neuron.2025.11.027. PubMed PMID:41412064 .
- Cirnigliaro, M, Lowe, JK, Flynn-Carroll, AO, Kumagai, ME, Gibson, DS, Fu, JM et al.. Common and rare variant genetic contributions in African Americans with autism. medRxiv. 2025; :. doi: 10.1101/2025.11.18.25340532. PubMed PMID:41332866 PubMed Central PMC12668067.
- Dimas, P, Morabito, S, Rawji, KS, Wang, Q, Krause, FN, Cubillos, J et al.. Dysregulation of transcription networks regulating oligodendrogenesis in age-related decline in CNS remyelination. bioRxiv. 2025; :. doi: 10.1101/2025.11.14.688494. PubMed PMID:41292837 PubMed Central PMC12642603.