Geschwind Daniel, M.D., Ph.D.

Research

Developmental neurogenetics

Appointments

• Director, Center for Autism Research and Treatment (CART)
• Professor, Neurology
• Psychiatry and Biobehavioral Sciences
• Co-Director, Center for Neurobehavioral Genetics
• Professor in Residence, Tennenbaum Center for the Biology of Creativity
• Human Genetics
• Member, Bioinformatics GPB Home Area
• Brain Research Institute
• CTSI
• Genetics & Genomics GPB Home Area
• Neuroscience GPB Home Area
• Research Education, Training, and Career Development Program (CTSI-ED)

Appointments

Dr. Geschwind’s laboratory conducts research in three primary areas of neurogenetics:

• autism and language;
• focal neurodegenerative syndromes;
• and the structural/molecular basis of human cognitive specializations.

Utilizing a multi-pronged approach, he studies normal human and animal model brain patterning to diseases in which language and social communication are disrupted, such as autism.

Publications

1. Shen, Y, Wong, SZH, Ma, T, Zhang, F, Wang, Q, Kawaguchi, R et al.. m⁶A deficiency impairs hypothalamic neurogenesis of feeding-related neurons in mice and human organoids and leads to adult obesity in mice. Cell Stem Cell. 2025; :. doi: 10.1016/j.stem.2025.02.011. PubMed PMID:40112816 .
2. Coulborn, S, Schafer, R, Roy, ARK, Sokolowski, A, Cryns, NG, Leichter, D et al.. Clinical and Imaging Features of Sporadic and Genetic Frontotemporal Lobar Degeneration TDP-43 A and B. Ann Clin Transl Neurol. 2025; :. doi: 10.1002/acn3.70014. PubMed PMID:40063407 .
3. Wang, H, Chang, TS, Dombroski, BA, Cheng, PL, Si, YQ, Tucci, A et al.. Copy Number Variation and Haplotype Analysis of 17q21.31 Reveals Increased Risk Associated with Progressive Supranuclear Palsy and Gene Expression Changes in Neuronal Cells. Mov Disord. 2025; :. doi: 10.1002/mds.30150. PubMed PMID:40055946 .
4. Lin, JP, Brake, A, Donadieu, M, Lee, A, Smith, G, Hu, K et al.. 4D marmoset brain map reveals MRI and molecular signatures for onset of multiple sclerosis-like lesions. Science. 2025;387 (6737):eadp6325. doi: 10.1126/science.adp6325. PubMed PMID:40014701 .
5. Sun, Y, Wang, X, Zhang, DY, Zhang, Z, Bhattarai, JP, Wang, Y et al.. Brain-wide neuronal circuit connectome of human glioblastoma. Nature. 2025; :. doi: 10.1038/s41586-025-08634-7. PubMed PMID:39821165 .

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