Intellectual and Developmental Disabilities Research Center

FACULTY

Geschwind Daniel, M.D., Ph.D.

Research

Developmental neurogenetics

Appointments

  • Director, Center for Autism Research and Treatment (CART)
  • Professor, Neurology
  • Psychiatry and Biobehavioral Sciences
  • Co-Director, Center for Neurobehavioral Genetics
  • Professor in Residence, Tennenbaum Center for the Biology of Creativity
  • Human Genetics
  • Member, Bioinformatics GPB Home Area
  • Brain Research Institute
  • CTSI
  • Genetics & Genomics GPB Home Area
  • Neuroscience GPB Home Area
  • Research Education, Training, and Career Development Program (CTSI-ED)

Appointments

Dr. Geschwind’s laboratory conducts research in three primary areas of neurogenetics:

  • autism and language;
  • focal neurodegenerative syndromes;
  • and the structural/molecular basis of human cognitive specializations.

Utilizing a multi-pronged approach, he studies normal human and animal model brain patterning to diseases in which language and social communication are disrupted, such as autism.

Publications

  1. Patel, KS, Tessema, KK, Kawaguchi, R, Dudley, L, Alvarado, AG, Muthukrishnan, SD et al.. Single-nucleus expression characterization of non-enhancing region of recurrent high-grade glioma. Neurooncol Adv. 2024;6 (1):vdae005. doi: 10.1093/noajnl/vdae005. PubMed PMID:38616896 PubMed Central PMC11012612.
  2. Chen, GT, Nair, G, Osorio, AJ, Holley, SM, Ghassemzadeh, K, Gonzalez, J et al.. Enhancer-targeted CRISPR-Activation Rescues Haploinsufficient Autism Susceptibility Genes. bioRxiv. 2024; :. doi: 10.1101/2024.03.13.584921. PubMed PMID:38559217 PubMed Central PMC10980046.
  3. Bicks, LK, Geschwind, DH. Functional neurogenomics in autism spectrum disorders: A decade of progress. Curr Opin Neurobiol. 2024;86 :102858. doi: 10.1016/j.conb.2024.102858. PubMed PMID:38547564 .
  4. Schmitd, LB, Hafner, H, Ward, A, Asghari Adib, E, Biscola, NP, Kohen, R et al.. Sarm1 is not necessary for activation of neuron-intrinsic growth programs yet required for the Schwann cell repair response and peripheral nerve regeneration. bioRxiv. 2024; :. doi: 10.1101/2024.03.04.583374. PubMed PMID:38496662 PubMed Central PMC10942360.
  5. Nazeen, S, Wang, X, Zielinski, D, Lam, I, Hallacli, E, Xu, P et al.. Deep sequencing of proteotoxicity modifier genes uncovers a Presenilin-2/beta-amyloid-actin genetic risk module shared among alpha-synucleinopathies. bioRxiv. 2024; :. doi: 10.1101/2024.03.03.583145. PubMed PMID:38496508 PubMed Central PMC10942362.
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