Research
Developmental neurogenetics
Appointments
- Director, Center for Autism Research and Treatment (CART)
- Professor, Neurology
- Psychiatry and Biobehavioral Sciences
- Co-Director, Center for Neurobehavioral Genetics
- Professor in Residence, Tennenbaum Center for the Biology of Creativity
- Human Genetics
- Member, Bioinformatics GPB Home Area
- Brain Research Institute
- CTSI
- Genetics & Genomics GPB Home Area
- Neuroscience GPB Home Area
- Research Education, Training, and Career Development Program (CTSI-ED)
Appointments
Dr. Geschwind’s laboratory conducts research in three primary areas of neurogenetics:
- autism and language;
- focal neurodegenerative syndromes;
- and the structural/molecular basis of human cognitive specializations.
Utilizing a multi-pronged approach, he studies normal human and animal model brain patterning to diseases in which language and social communication are disrupted, such as autism.
Publications
- Xia, W, Morcom, L, Xu, Z, Lu, IL, Wang, Q, Hoi, KK et al.. Expansion of outer cortical CUX2 neurons requires adaptations for DNA repair. Nature. 2026; :. doi: 10.1038/s41586-026-10290-4. PubMed PMID:41922774 .
- Haas, R, Margolis, MP, Wei, A, Yamaguchi, TN, Feng, J, Tran, T et al.. Advancing precision health discovery in a genetically diverse health system. Cell. 2026; :. doi: 10.1016/j.cell.2026.03.007. PubMed PMID:41903539 .
- Contreras, AG, Walters, S, Eissman, JM, Archer, DB, Regelson, AN, Durant, A et al.. Genetic modifiers of APOE-ε4-associated cognitive decline. Nat Commun. 2026;17 (1):. doi: 10.1038/s41467-026-68933-z. PubMed PMID:41720779 PubMed Central PMC13036010.
- Kumar, M, Schlaffner, CN, Tang, S, Beuvink, MA, Viode, A, Mair, W et al.. Molecular features of human pathological tau distinguish tauopathy-associated dementias. Cell. 2026;189 (3):956-968.e13. doi: 10.1016/j.cell.2025.12.036. PubMed PMID:41616780 .
- Gordon, A, Yoon, SJ, Bicks, LK, Martín, JM, Pintacuda, G, Arteaga, S et al.. Developmental convergence and divergence in human stem cell models of autism. Nature. 2026;651 (8106):707-719. doi: 10.1038/s41586-025-10047-5. PubMed PMID:41611887 PubMed Central PMC12999519.