Intellectual and Developmental Disabilities Research Center

FACULTY

Geschwind Daniel, M.D., Ph.D.

Research

Developmental neurogenetics

Appointments

  • Director, Center for Autism Research and Treatment (CART)
  • Professor, Neurology
  • Psychiatry and Biobehavioral Sciences
  • Co-Director, Center for Neurobehavioral Genetics
  • Professor in Residence, Tennenbaum Center for the Biology of Creativity
  • Human Genetics
  • Member, Bioinformatics GPB Home Area
  • Brain Research Institute
  • CTSI
  • Genetics & Genomics GPB Home Area
  • Neuroscience GPB Home Area
  • Research Education, Training, and Career Development Program (CTSI-ED)

Appointments

Dr. Geschwind’s laboratory conducts research in three primary areas of neurogenetics:

  • autism and language;
  • focal neurodegenerative syndromes;
  • and the structural/molecular basis of human cognitive specializations.

Utilizing a multi-pronged approach, he studies normal human and animal model brain patterning to diseases in which language and social communication are disrupted, such as autism.

Publications

  1. Rexach, JE, Cheng, Y, Chen, L, Polioudakis, D, Lin, LC, Mitri, V et al.. Cross-disorder and disease-specific pathways in dementia revealed by single-cell genomics. Cell. 2024; :. doi: 10.1016/j.cell.2024.08.019. PubMed PMID:39265576 .
  2. Farrell, K, Humphrey, J, Chang, T, Zhao, Y, Leung, YY, Kuksa, PP et al.. Genetic, transcriptomic, histological, and biochemical analysis of progressive supranuclear palsy implicates glial activation and novel risk genes. Nat Commun. 2024;15 (1):7880. doi: 10.1038/s41467-024-52025-x. PubMed PMID:39251599 PubMed Central PMC11385559.
  3. Wang, H, Chang, TS, Dombroski, BA, Cheng, PL, Patil, V, Valiente-Banuet, L et al.. Whole-genome sequencing analysis reveals new susceptibility loci and structural variants associated with progressive supranuclear palsy. Mol Neurodegener. 2024;19 (1):61. doi: 10.1186/s13024-024-00747-3. PubMed PMID:39152475 PubMed Central PMC11330058.
  4. Zhang, X, Grove, J, Gu, Y, Buus, CK, Nielsen, LK, Neufeld, SAS et al.. An axis of genetic heterogeneity in autism is indexed by age at diagnosis and is associated with varying developmental and mental health profiles. medRxiv. 2024; :. doi: 10.1101/2024.07.31.24311279. PubMed PMID:39132493 PubMed Central PMC11312648.
  5. Kosmicki, JA, Marcketta, A, Sharma, D, Di Gioia, SA, Batista, S, Yang, XM et al.. Genetic risk factors for COVID-19 and influenza are largely distinct. Nat Genet. 2024;56 (8):1592-1596. doi: 10.1038/s41588-024-01844-1. PubMed PMID:39103650 PubMed Central PMC11319199.
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