Research
Developmental neurogenetics
Appointments
- Director, Center for Autism Research and Treatment (CART)
- Professor, Neurology
- Psychiatry and Biobehavioral Sciences
- Co-Director, Center for Neurobehavioral Genetics
- Professor in Residence, Tennenbaum Center for the Biology of Creativity
- Human Genetics
- Member, Bioinformatics GPB Home Area
- Brain Research Institute
- CTSI
- Genetics & Genomics GPB Home Area
- Neuroscience GPB Home Area
- Research Education, Training, and Career Development Program (CTSI-ED)
Appointments
Dr. Geschwind’s laboratory conducts research in three primary areas of neurogenetics:
- autism and language;
- focal neurodegenerative syndromes;
- and the structural/molecular basis of human cognitive specializations.
Utilizing a multi-pronged approach, he studies normal human and animal model brain patterning to diseases in which language and social communication are disrupted, such as autism.
Publications
- Eyring, KW, Liu, C, Elhajjaoui, N, Abuhanna, KD, Zhang, Y, von Behren, Z et al.. Single-cell profiling of DNA methylation in autism spectrum disorder prefrontal cortex reveals distinct regulatory and aging signatures. Cell Genom. 2026; :101278. doi: 10.1016/j.xgen.2026.101278. PubMed PMID:42320469 .
- Chorsi, H, Soldado-Magraner, S, Jin, Y, Soltanalipouryekesammak, I, Zheng, A, Markovic, D et al.. STIMscope: centimeter-scale all-optical imaging and patterned optogenetic manipulation at single-cell resolution. bioRxiv. 2026; :. doi: 10.64898/2026.05.27.728160. PubMed PMID:42244717 PubMed Central PMC13232196.
- EADB, EADI, Bonn, ADGC, CHARGE, FinnGen et al.. Consensus meta-analysis of genome-wide association studies for Alzheimer's disease and related dementias. Nat Genet. 2026;58 (6):1214-1225. doi: 10.1038/s41588-026-02583-1. PubMed PMID:42237039 PubMed Central PMC13263136.
- Baron-Cohen, S, Tsompanidis, A, Srivastava, DP, Mill, J, Lancaster, MA, Adhya, D et al.. The prenatal sex steroid theory of autism after 25 years. Nat Hum Behav. 2026;10 (5):841-848. doi: 10.1038/s41562-026-02437-0. PubMed PMID:42162383 .
- Vuong, CK, Weber, A, Seong, P, Matoba, N, Chen, YJ, Peyer, J et al.. A single-cell multiomic analysis identifies molecular and gene-regulatory mechanisms dysregulated in developing Down syndrome neocortex. Science. 2026;392 (6796):eaea1259. doi: 10.1126/science.aea1259. PubMed PMID:42024758 PubMed Central PMC13225313.