Geschwind Daniel, M.D., Ph.D.

Research

Developmental neurogenetics

Appointments

• Director, Center for Autism Research and Treatment (CART)
• Professor, Neurology
• Psychiatry and Biobehavioral Sciences
• Co-Director, Center for Neurobehavioral Genetics
• Professor in Residence, Tennenbaum Center for the Biology of Creativity
• Human Genetics
• Member, Bioinformatics GPB Home Area
• Brain Research Institute
• CTSI
• Genetics & Genomics GPB Home Area
• Neuroscience GPB Home Area
• Research Education, Training, and Career Development Program (CTSI-ED)

Appointments

Dr. Geschwind’s laboratory conducts research in three primary areas of neurogenetics:

• autism and language;
• focal neurodegenerative syndromes;
• and the structural/molecular basis of human cognitive specializations.

Utilizing a multi-pronged approach, he studies normal human and animal model brain patterning to diseases in which language and social communication are disrupted, such as autism.

Publications

1. Dimas, P, Morabito, S, Rawji, KS, Wang, Q, Krause, FN, Cubillos, J et al.. Dysregulation of transcription networks regulating oligodendrogenesis in age-related decline in CNS remyelination. bioRxiv. 2025; :. doi: 10.1101/2025.11.14.688494. PubMed PMID:41292837 PubMed Central PMC12642603.
2. McDiarmid, TA, Page, NF, Chardon, FM, Daza, RM, Chen, GT, Kosicki, M et al.. Large-scale discovery of neural enhancers for cis-regulation therapies. bioRxiv. 2025; :. doi: 10.1101/2025.11.04.686611. PubMed PMID:41278953 PubMed Central PMC12637570.
3. Schmitd, LB, Hafner, H, Ward, A, Asghari Adib, E, Biscola, NP, Kohen, R et al.. Deletion of murine Sarm1 results in a microenvironment that delays peripheral nerve regeneration after injury. Sci Transl Med. 2025;17 (819):eadp9155. doi: 10.1126/scitranslmed.adp9155. PubMed PMID:41061042 .
4. Zhang, X, Grove, J, Gu, Y, Buus, CK, Nielsen, LK, Neufeld, SAS et al.. Polygenic and developmental profiles of autism differ by age at diagnosis. Nature. 2025;646 (8087):1146-1155. doi: 10.1038/s41586-025-09542-6. PubMed PMID:41034588 PubMed Central PMC12571882.
5. Rosenberg, GM, Murray, KA, Sawaya, MR, Jiang, YX, Geschwind, DH, Eisenberg, DS et al.. Genetic and structural aspects of amyloid diseases. Sci Transl Med. 2025;17 (818):eadp3378. doi: 10.1126/scitranslmed.adp3378. PubMed PMID:41032625 .

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