Geschwind Daniel, M.D., Ph.D.

Research

Developmental neurogenetics

Appointments

• Director, Center for Autism Research and Treatment (CART)
• Professor, Neurology
• Psychiatry and Biobehavioral Sciences
• Co-Director, Center for Neurobehavioral Genetics
• Professor in Residence, Tennenbaum Center for the Biology of Creativity
• Human Genetics
• Member, Bioinformatics GPB Home Area
• Brain Research Institute
• CTSI
• Genetics & Genomics GPB Home Area
• Neuroscience GPB Home Area
• Research Education, Training, and Career Development Program (CTSI-ED)

Appointments

Dr. Geschwind’s laboratory conducts research in three primary areas of neurogenetics:

• autism and language;
• focal neurodegenerative syndromes;
• and the structural/molecular basis of human cognitive specializations.

Utilizing a multi-pronged approach, he studies normal human and animal model brain patterning to diseases in which language and social communication are disrupted, such as autism.

Publications

1. Pottier, C, Küçükali, F, Baker, M, Batzler, A, Jenkins, GD, van Blitterswijk, M et al.. Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing. Nat Commun. 2025;16 (1):3914. doi: 10.1038/s41467-025-59216-0. PubMed PMID:40280976 PubMed Central PMC12032271.
2. Shim, J, Tanaka, B, Taub, DG, Mis, MA, Schulman, BR, Snavely, A et al.. Correction of sodium channel mutations in sensory neurons reverses aberrant properties. Brain. 2025; :. doi: 10.1093/brain/awaf155. PubMed PMID:40279376 .
3. Liu, X, de Boer, SCM, Cortez, K, Poos, JM, Illán-Gala, I, Heuer, H et al.. Sex differences in clinical phenotypes of behavioral variant frontotemporal dementia. Alzheimers Dement. 2025;21 (4):e14608. doi: 10.1002/alz.14608. PubMed PMID:40277074 PubMed Central PMC12022892.
4. Shen, Y, Wong, SZH, Ma, T, Zhang, F, Wang, Q, Kawaguchi, R et al.. m⁶A deficiency impairs hypothalamic neurogenesis of feeding-related neurons in mice and human organoids and leads to adult obesity in mice. Cell Stem Cell. 2025;32 (5):727-743.e8. doi: 10.1016/j.stem.2025.02.011. PubMed PMID:40112816 .
5. Coulborn, S, Schafer, R, Roy, ARK, Sokolowski, A, Cryns, NG, Leichter, D et al.. Clinical and Imaging Features of Sporadic and Genetic Frontotemporal Lobar Degeneration TDP-43 A and B. Ann Clin Transl Neurol. 2025; :. doi: 10.1002/acn3.70014. PubMed PMID:40063407 .

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