Intellectual and Developmental Disabilities Research Center

FACULTY

Golshani, Peyman, M.D., Ph.D.

Research

GABAergic network function in awake behaving mice; GABAergic network dysfunction in models of autism and developmental epilepsy

Appointments

  • Associate Professor, Neurology
  • Neurologist, West LA VA Medical Center

Biography

The Golshani Lab is focused on understanding how changes in the connectivity and excitability of cortical circuits results in autism and intellectual disability.

We use cutting edge tools, such as in-vivo two-photon calcium imaging, high density silicon probe recordings, and miniaturized microscopes to determine how large groups of identified neurons change their ensemble firing patterns in models of disease during behavior.

By understanding the mechanisms underlying circuit dysfunction, we hope to find new-generation treatments for these conditions.

Publications

  1. Bellafard, A, Namvar, G, Kao, JC, Vaziri, A, Golshani, P. Volatile working memory representations crystallize with practice. Nature. 2024; :. doi: 10.1038/s41586-024-07425-w. PubMed PMID:38750359 .
  2. Iranifam, M, Royan, M, Golshani, P, Hassanpour-Khaneghah, M, Al Lawati, HAJ. FeS2 nanosheets-luminol-O2 chemiluminescence method for determination of venlafaxine hydrochloride, imipramine hydrochloride, and cefazolin sodium. Luminescence. 2024;39 (4):e4745. doi: 10.1002/bio.4745. PubMed PMID:38644416 .
  3. Gerdin, A, Park, J, Häggström, J, Segelman, J, Matthiessen, P, Lydrup, ML et al.. Preoperative beta blockers and other drugs in relation to anastomotic leakage after anterior resection for rectal cancer. Colorectal Dis. 2024; :. doi: 10.1111/codi.16933. PubMed PMID:38462750 .
  4. Hur, SW, Safaryan, K, Yang, L, Blair, HT, Masmanidis, SC, Mathews, PJ et al.. Correlated signatures of social behavior in cerebellum and anterior cingulate cortex. Elife. 2024;12 :. doi: 10.7554/eLife.88439. PubMed PMID:38345922 PubMed Central PMC10942583.
  5. Rutegård, M, Svensson, J, Segelman, J, Matthiessen, P, Lydrup, ML, Park, JM et al.. Anastomotic Leakage in Relation to Type of Mesorectal Excision and Defunctioning Stoma Use in Anterior Resection for Rectal Cancer. Dis Colon Rectum. 2024;67 (3):398-405. doi: 10.1097/DCR.0000000000003050. PubMed PMID:37994449 .
Search PubMed