Golshani, Peyman, M.D., Ph.D.

Research

GABAergic network function in awake behaving mice; GABAergic network dysfunction in models of autism and developmental epilepsy

Appointments

• Associate Professor, Neurology
• Neurologist, West LA VA Medical Center

Biography

The Golshani Lab is focused on understanding how changes in the connectivity and excitability of cortical circuits results in autism and intellectual disability.

We use cutting edge tools, such as in-vivo two-photon calcium imaging, high density silicon probe recordings, and miniaturized microscopes to determine how large groups of identified neurons change their ensemble firing patterns in models of disease during behavior.

By understanding the mechanisms underlying circuit dysfunction, we hope to find new-generation treatments for these conditions.

Publications

1. Zhao, P, Aharoni, D, Golshani, P. GRIN lens implantation strategies for in vivo calcium imaging using miniature microscopy. PLoS One. 2025;20 (5):e0323256. doi: 10.1371/journal.pone.0323256. PubMed PMID:40354432 PubMed Central PMC12068630.
2. Dong, HW, Hintiryan, H, Zhu, M, Zhao, P, Zhang, M, Barry, J et al.. Neural Networks of the Mouse Primary Visceromotor Cortex. Res Sq. 2025; :. doi: 10.21203/rs.3.rs-4125909/v1. PubMed PMID:40343331 PubMed Central PMC12060971.
3. Dorian, CC, Taxidis, J, Buonomano, D, Golshani, P. Hippocampal sequences represent working memory and implicit timing. bioRxiv. 2025; :. doi: 10.1101/2025.03.17.643736. PubMed PMID:40166270 PubMed Central PMC11956965.
4. Hao, YA, Lee, S, Roth, RH, Natale, S, Gomez, L, Taxidis, J et al.. A fast and responsive voltage indicator with enhanced sensitivity for unitary synaptic events. Neuron. 2024;112 (22):3680-3696.e8. doi: 10.1016/j.neuron.2024.08.019. PubMed PMID:39305894 PubMed Central PMC11581914.
5. Dorian, CC, Taxidis, J, Arac, A, Golshani, P. Behavioral timescale synaptic plasticity in the hippocampus creates non-spatial representations during learning and is modulated by entorhinal inputs. bioRxiv. 2025; :. doi: 10.1101/2024.08.27.609983. PubMed PMID:39253411 PubMed Central PMC11383060.

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