Golshani, Peyman, M.D., Ph.D.

Research

GABAergic network function in awake behaving mice; GABAergic network dysfunction in models of autism and developmental epilepsy

Appointments

• Associate Professor, Neurology
• Neurologist, West LA VA Medical Center

Biography

The Golshani Lab is focused on understanding how changes in the connectivity and excitability of cortical circuits results in autism and intellectual disability.

We use cutting edge tools, such as in-vivo two-photon calcium imaging, high density silicon probe recordings, and miniaturized microscopes to determine how large groups of identified neurons change their ensemble firing patterns in models of disease during behavior.

By understanding the mechanisms underlying circuit dysfunction, we hope to find new-generation treatments for these conditions.

Publications

1. Saravanapandian, V, Madani, M, Nichols, I, Vincent, S, Dover, M, Dikeman, D et al.. Sleep EEG signatures in mouse models of 15q11.2-13.1 duplication (Dup15q) syndrome. J Neurodev Disord. 2024;16 (1):39. doi: 10.1186/s11689-024-09556-7. PubMed PMID:39014349 PubMed Central PMC11251350.
2. Hajnal, MA, Tran, D, Szabó, Z, Albert, A, Safaryan, K, Einstein, M et al.. Shifts in attention drive context-dependent subspace encoding in anterior cingulate cortex in mice during decision making. Nat Commun. 2024;15 (1):5559. doi: 10.1038/s41467-024-49845-2. PubMed PMID:38956080 PubMed Central PMC11220070.
3. Bellafard, A, Namvar, G, Kao, JC, Vaziri, A, Golshani, P. Volatile working memory representations crystallize with practice. Nature. 2024;629 (8014):1109-1117. doi: 10.1038/s41586-024-07425-w. PubMed PMID:38750359 PubMed Central PMC11136659.
4. Iranifam, M, Royan, M, Golshani, P, Hassanpour-Khaneghah, M, Al Lawati, HAJ. FeS₂ nanosheets-luminol-O₂ chemiluminescence method for determination of venlafaxine hydrochloride, imipramine hydrochloride, and cefazolin sodium. Luminescence. 2024;39 (4):e4745. doi: 10.1002/bio.4745. PubMed PMID:38644416 .
5. Gerdin, A, Park, J, Häggström, J, Segelman, J, Matthiessen, P, Lydrup, ML et al.. Preoperative beta blockers and other drugs in relation to anastomotic leakage after anterior resection for rectal cancer. Colorectal Dis. 2024;26 (5):974-986. doi: 10.1111/codi.16933. PubMed PMID:38462750 .

Search PubMed