Research
GABAergic network function in awake behaving mice; GABAergic network dysfunction in models of autism and developmental epilepsy
Appointments
- Associate Professor, Neurology
- Neurologist, West LA VA Medical Center
Biography
The Golshani Lab is focused on understanding how changes in the connectivity and excitability of cortical circuits results in autism and intellectual disability.
We use cutting edge tools, such as in-vivo two-photon calcium imaging, high density silicon probe recordings, and miniaturized microscopes to determine how large groups of identified neurons change their ensemble firing patterns in models of disease during behavior.
By understanding the mechanisms underlying circuit dysfunction, we hope to find new-generation treatments for these conditions.
Publications
- Madruga, BA, Dorian, CC, Yang, L, Sehgal, M, Silva, AJ, Shtrahman, M et al.. Open-source, high performance miniature 2-photon microscopy systems for freely behaving animals. Nat Commun. 2025;16 (1):7125. doi: 10.1038/s41467-025-62534-y. PubMed PMID:40753159 PubMed Central PMC12318034.
- Taxidis, J, Madruga, B, Safaryan, K, Dorian, CC, Melin, MD, Day, Z et al.. Voltage imaging reveals hippocampal inhibitory dynamics shaping pyramidal memory-encoding sequences. Nat Neurosci. 2025; :. doi: 10.1038/s41593-025-02016-y. PubMed PMID:40696029 .
- Zhao, P, Guo, C, Xie, M, Chen, L, Golshani, P, Aharoni, D et al.. MiniXL: An open-source, large field-of-view epifluorescence miniscope enabling single-cell resolution and multi-region imaging in mice. Sci Adv. 2025;11 (24):eads4995. doi: 10.1126/sciadv.ads4995. PubMed PMID:40498840 PubMed Central PMC12154187.
- Zhao, P, Aharoni, D, Golshani, P. GRIN lens implantation strategies for in vivo calcium imaging using miniature microscopy. PLoS One. 2025;20 (5):e0323256. doi: 10.1371/journal.pone.0323256. PubMed PMID:40354432 PubMed Central PMC12068630.
- Dong, HW, Hintiryan, H, Zhu, M, Zhao, P, Zhang, M, Barry, J et al.. Neural Networks of the Mouse Primary Visceromotor Cortex. Res Sq. 2025; :. doi: 10.21203/rs.3.rs-4125909/v1. PubMed PMID:40343331 PubMed Central PMC12060971.