Intellectual and Developmental Disabilities Research Center

Members

Golshani, Peyman, M.D., Ph.D.

Research

GABAergic network function in awake behaving mice; GABAergic network dysfunction in models of autism and developmental epilepsy

Appointments

  • Associate Professor, Neurology
  • Neurologist, West LA VA Medical Center

Biography

The Golshani Lab is focused on understanding how changes in the connectivity and excitability of cortical circuits results in autism and intellectual disability.

We use cutting edge tools, such as in-vivo two-photon calcium imaging, high density silicon probe recordings, and miniaturized microscopes to determine how large groups of identified neurons change their ensemble firing patterns in models of disease during behavior.

By understanding the mechanisms underlying circuit dysfunction, we hope to find new-generation treatments for these conditions.

Publications

  1. Sasatani, T, Brosch, M, Dong, Z, Saunders, J, Zhao, P, Sehgal, M et al.. Miniscope Zero: a fully wireless, single-cell-resolution miniature microscope for imaging neural dynamics in freely behaving animals. bioRxiv. 2026; :. doi: 10.64898/2026.09.05.745822. PubMed PMID:42818601 PubMed Central PMC13622490.
  2. Rutegård, M, Segelman, J, Matthiessen, P, Lydrup, ML, Park, J, RectoLeak Study Group et al.. Early inflammatory signal in late-diagnosed anastomotic leakage after anterior resection. BJS Open. 2026;10 (5):. doi: 10.1093/bjsopen/zrag127. PubMed PMID:42809715 PubMed Central PMC13623004.
  3. Zhao, P, Chen, X, Bellafard, A, Murugesan, A, Quan, J, Aharoni, D et al.. Cell-type-specific disruption of nucleus accumbens social representations in a mouse model of autism. Neuron. 2026; :. doi: 10.1016/j.neuron.2026.08.007. PubMed PMID:42721965 PubMed Central PMC13608005.
  4. Ho, V, Tjondropurnomo, R, Nguyen, J, Balkó, E, Depew, S, Chen, X et al.. Single-nucleus transcriptomics reveals cell type-specific remodeling and epilepsy-associated microglia. iScience. 2026;29 (9):117228. doi: 10.1016/j.isci.2026.117228. PubMed PMID:42662868 PubMed Central PMC13521094.
  5. Golshani, P, Joseph, MS. Three Decades of Food and Drug Administration Authorizations of Artificial Intelligence/Machine Learning-Enabled Medical Devices: Persistent Specialty Concentration and the Care-Delivery Gap (1995-2025). Cureus. 2026;18 (7):e112583. doi: 10.7759/cureus.112583. PubMed PMID:42592195 PubMed Central PMC13464356.
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