Research
GABAergic network function in awake behaving mice; GABAergic network dysfunction in models of autism and developmental epilepsy
Appointments
- Associate Professor, Neurology
- Neurologist, West LA VA Medical Center
Biography
The Golshani Lab is focused on understanding how changes in the connectivity and excitability of cortical circuits results in autism and intellectual disability.
We use cutting edge tools, such as in-vivo two-photon calcium imaging, high density silicon probe recordings, and miniaturized microscopes to determine how large groups of identified neurons change their ensemble firing patterns in models of disease during behavior.
By understanding the mechanisms underlying circuit dysfunction, we hope to find new-generation treatments for these conditions.
Publications
- Dorian, CC, Taxidis, J, Buonomano, D, Golshani, P. Hippocampal sequences represent working memory and implicit timing. bioRxiv. 2025; :. doi: 10.1101/2025.03.17.643736. PubMed PMID:40166270 PubMed Central PMC11956965.
- Hao, YA, Lee, S, Roth, RH, Natale, S, Gomez, L, Taxidis, J et al.. A fast and responsive voltage indicator with enhanced sensitivity for unitary synaptic events. Neuron. 2024;112 (22):3680-3696.e8. doi: 10.1016/j.neuron.2024.08.019. PubMed PMID:39305894 PubMed Central PMC11581914.
- Dorian, CC, Taxidis, J, Arac, A, Golshani, P. Behavioral timescale synaptic plasticity in the hippocampus creates non-spatial representations during learning and is modulated by entorhinal inputs. bioRxiv. 2025; :. doi: 10.1101/2024.08.27.609983. PubMed PMID:39253411 PubMed Central PMC11383060.
- Zhao, P, Guo, C, Xie, M, Chen, L, Golshani, P, Aharoni, D et al.. MiniXL: An open-source, large field-of-view epifluorescence miniature microscope for mice capable of single-cell resolution and multi-brain region imaging. bioRxiv. 2024; :. doi: 10.1101/2024.08.16.608328. PubMed PMID:39229051 PubMed Central PMC11370419.
- Saravanapandian, V, Madani, M, Nichols, I, Vincent, S, Dover, M, Dikeman, D et al.. Sleep EEG signatures in mouse models of 15q11.2-13.1 duplication (Dup15q) syndrome. J Neurodev Disord. 2024;16 (1):39. doi: 10.1186/s11689-024-09556-7. PubMed PMID:39014349 PubMed Central PMC11251350.