Intellectual and Developmental Disabilities Research Center

FACULTY

Kornblum, Harley I., M.D., Ph.D.

Research

Neural stem cells, neural repair, and brain tumors

Appointments

  • Professor, Pediatrics
  • Psychiatry and Biobehavioral Sciences
  • Pediatric Neurology
  • Semel Institute for Neuroscience and Human Behavior
  • Molecular & Medical Pharmacology
  • Member, Brain Research Institute
  • Cell & Developmental Biology GPB Home Area
  • Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research
  • JCCC Cancer and Stem Cell Biology Program Area
  • Molecular Pharmacology GPB Home Area
  • Neuroscience GPB Home Area

Biography

Dr. Kornblum’s laboratory works in the areas of neurodevelopment, neural repair and brain tumors. He is one of the co-discoverers of stem cell-like cells in brain tumors. These cells are thought to be critical means by which brain tumors resist therapies. Dr. Kornblum’s laboratory is investigating a number of means to overcome this therapeutic resistance.

In addition to brain tumors, Dr. Kornblum’s research is relevant to the areas of autism, spinal cord injury, stroke and cerebral palsy, as well as other developmental disorders of the nervous system.

Publications

  1. Patel, KS, Tessema, KK, Kawaguchi, R, Dudley, L, Alvarado, AG, Muthukrishnan, SD et al.. Single-nucleus expression characterization of non-enhancing region of recurrent high-grade glioma. Neurooncol Adv. 2024;6 (1):vdae005. doi: 10.1093/noajnl/vdae005. PubMed PMID:38616896 PubMed Central PMC11012612.
  2. Pianka, ST, Li, T, Prins, TJ, Eldred, BSC, Kevan, BM, Liang, H et al.. D-2-HG Inhibits IDH1mut Glioma Growth via FTO Inhibition and Resultant m6A Hypermethylation. Cancer Res Commun. 2024;4 (3):876-894. doi: 10.1158/2767-9764.CRC-23-0271. PubMed PMID:38445960 PubMed Central PMC10959073.
  3. Muthukrishnan, SD, Qi, H, Wang, D, Elahi, L, Pham, A, Alvarado, AG et al.. Low- and high-grade glioma-associated vascular cells differentially regulate tumor growth. Mol Cancer Res. 2024; :. doi: 10.1158/1541-7786.MCR-23-1069. PubMed PMID:38441553 .
  4. Sohrabi, A, Lefebvre, AEYT, Harrison, MJ, Condro, MC, Sanazzaro, TM, Safarians, G et al.. Microenvironmental stiffness induces metabolic reprogramming in glioblastoma. Cell Rep. 2023;42 (10):113175. doi: 10.1016/j.celrep.2023.113175. PubMed PMID:37756163 PubMed Central PMC10842372.
  5. Patel, KS, Yao, J, Cho, NS, Sanvito, F, Tessema, K, Alvarado, A et al.. pH-Weighted amine chemical exchange saturation transfer echo planar imaging visualizes infiltrating glioblastoma cells. Neuro Oncol. 2024;26 (1):115-126. doi: 10.1093/neuonc/noad150. PubMed PMID:37591790 PubMed Central PMC10768991.
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