Research
Neural stem cells, neural repair, and brain tumors
Appointments
- Professor, Pediatrics
- Psychiatry and Biobehavioral Sciences
- Pediatric Neurology
- Semel Institute for Neuroscience and Human Behavior
- Molecular & Medical Pharmacology
- Member, Brain Research Institute
- Cell & Developmental Biology GPB Home Area
- Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research
- JCCC Cancer and Stem Cell Biology Program Area
- Molecular Pharmacology GPB Home Area
- Neuroscience GPB Home Area
Biography
Dr. Kornblum’s laboratory works in the areas of neurodevelopment, neural repair and brain tumors. He is one of the co-discoverers of stem cell-like cells in brain tumors. These cells are thought to be critical means by which brain tumors resist therapies. Dr. Kornblum’s laboratory is investigating a number of means to overcome this therapeutic resistance.
In addition to brain tumors, Dr. Kornblum’s research is relevant to the areas of autism, spinal cord injury, stroke and cerebral palsy, as well as other developmental disorders of the nervous system.
Publications
- Le Belle, JE, Condro, M, Cepeda, C, Oikonomou, KD, Tessema, K, Dudley, L et al.. Acute rapamycin treatment reveals novel mechanisms of behavioral, physiological, and functional dysfunction in a maternal inflammation mouse model of autism and sensory over-responsivity. bioRxiv. 2024; :. doi: 10.1101/2024.07.08.602602. PubMed PMID:39026891 PubMed Central PMC11257517.
- He, L, Ioannidis, A, Hoffman, CJ, Arambula, E, Joshi, P, Whitelegge, J et al.. Activation of the Mevalonate Pathway in Response to Anti-cancer Treatments Drives Glioblastoma Recurrences Through Activation of Rac-1. Cancer Res Commun. 2024;4 (6):1566-1580. doi: 10.1158/2767-9764.CRC-24-0049. PubMed PMID:38837899 PubMed Central PMC11197925.
- He, L, Azizad, D, Bhat, K, Ioannidis, A, Hoffmann, CJ, Arambula, E et al.. Radiation-Induced Cellular Plasticity: A Strategy for Combatting Glioblastoma. bioRxiv. 2024; :. doi: 10.1101/2024.05.13.593985. PubMed PMID:38798647 PubMed Central PMC11118449.
- Patel, KS, Tessema, KK, Kawaguchi, R, Dudley, L, Alvarado, AG, Muthukrishnan, SD et al.. Single-nucleus expression characterization of non-enhancing region of recurrent high-grade glioma. Neurooncol Adv. 2024;6 (1):vdae005. doi: 10.1093/noajnl/vdae005. PubMed PMID:38616896 PubMed Central PMC11012612.
- Pianka, ST, Li, T, Prins, TJ, Eldred, BSC, Kevan, BM, Liang, H et al.. D-2-HG Inhibits IDH1mut Glioma Growth via FTO Inhibition and Resultant m6A Hypermethylation. Cancer Res Commun. 2024;4 (3):876-894. doi: 10.1158/2767-9764.CRC-23-0271. PubMed PMID:38445960 PubMed Central PMC10959073.