Intellectual and Developmental Disabilities Research Center

FACULTY

Krantz, David E., M.D., Ph.D.

Research

Regulation of neurotransmitter transporters in Drosophila

Appointments

  • Associate Professor, Hatos Center for Neuropharmacology
  • Assistant Professor, Psychiatry and Biobehavioral Sciences
  • Member, ACCESS Program: Neuroscience IDP
  • Neuroscience IDP
  • Brain Research Institute
  • Center for Neurodegenerative Disease Studies
  • Faculty, Molecular Toxicology IDP

Biography

Dr. Krantz is interested in the molecular mechanisms that regulate synaptic transmission, and the relationship between changes in neurotransmitter release and neuropsychiatric illnesses such as depression and Parkinson’s disease.

His laboratory focuses on the function of neurotransmitter transporters, the proteins responsible for transporting neurotransmitters such as dopamine and serotonin across biological membranes.

Using a variety of molecular and genetic techniques, Dr. Krantz’s laboratory studies how neurotransmitter transport is regulated in cultured cells and in the model organism Drosophila, and how changes in transporter function may influence behavior.

Publications

  1. Leuchter, MK, Citrenbaum, C, Wilson, AC, Tibbe, TD, Jackson, NJ, Krantz, DE et al.. The effect of older age on outcomes of rTMS treatment for treatment-resistant depression. Int Psychogeriatr. 2024; :1-6. doi: 10.1017/S1041610224000462. PubMed PMID:38525670 .
  2. Rohrbach, EW, Knapp, EM, Deshpande, SA, Krantz, DE. Expression and potential regulatory functions of Drosophila octopamine receptors in the female reproductive tract. G3 (Bethesda). 2024;14 (3):. doi: 10.1093/g3journal/jkae012. PubMed PMID:38244217 PubMed Central PMC10917510.
  3. Bonanno, SL, Sanfilippo, P, Eamani, A, Sampson, MM, Binu, K, Li, K et al.. Constitutive and conditional epitope-tagging of endogenous G protein coupled receptors in Drosophila. bioRxiv. 2023; :. doi: 10.1101/2023.12.27.573472. PubMed PMID:38234787 PubMed Central PMC10793450.
  4. Leuchter, MK, Citrenbaum, C, Wilson, AC, Tibbe, TD, Jackson, NJ, Krantz, DE et al.. A comparison of self- and observer-rated scales for detecting clinical improvement during repetitive transcranial stimulation (rTMS) treatment of depression. Psychiatry Res. 2023;330 :115608. doi: 10.1016/j.psychres.2023.115608. PubMed PMID:37984281 .
  5. Asuncion, JD, Eamani, A, Rohrbach, EW, Knapp, EM, Deshpande, SA, Bonanno, SL et al.. Precise CRISPR-Cas9-mediated mutation of a membrane trafficking domain in the Drosophila vesicular monoamine transporter gene. Curr Res Physiol. 2023;6 :100101. doi: 10.1016/j.crphys.2023.100101. PubMed PMID:37409154 PubMed Central PMC10318446.
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