Research
Regulation of neurotransmitter transporters in Drosophila
Appointments
- Associate Professor, Hatos Center for Neuropharmacology
- Assistant Professor, Psychiatry and Biobehavioral Sciences
- Member, ACCESS Program: Neuroscience IDP
- Neuroscience IDP
- Brain Research Institute
- Center for Neurodegenerative Disease Studies
- Faculty, Molecular Toxicology IDP
Biography
Dr. Krantz is interested in the molecular mechanisms that regulate synaptic transmission, and the relationship between changes in neurotransmitter release and neuropsychiatric illnesses such as depression and Parkinson’s disease.
His laboratory focuses on the function of neurotransmitter transporters, the proteins responsible for transporting neurotransmitters such as dopamine and serotonin across biological membranes.
Using a variety of molecular and genetic techniques, Dr. Krantz’s laboratory studies how neurotransmitter transport is regulated in cultured cells and in the model organism Drosophila, and how changes in transporter function may influence behavior.
Publications
- Dunn, W, Bershad, A, Krantz, DE, Vermetten, E. MDMA for treatment of PTSD and neurorehabilitation in military populations. NeuroRehabilitation. 2024;55 (3):357-368. doi: 10.3233/NRE-230270. PubMed PMID:39331116 .
- Slan, AR, Citrenbaum, C, Corlier, J, Ngo, D, Vince-Cruz, N, Jackson, NJ et al.. The role of sex and age in the differential efficacy of 10 Hz and intermittent theta-burst (iTBS) repetitive transcranial magnetic stimulation (rTMS) treatment of major depressive disorder (MDD). J Affect Disord. 2024;366 :106-112. doi: 10.1016/j.jad.2024.08.129. PubMed PMID:39187197 .
- Rohrbach, EW, Asuncion, JD, Meera, P, Kralovec, M, Deshpande, SA, Schweizer, FE et al.. Heterogeneity in the projections and excitability of tyraminergic/octopaminergic neurons that innervate the Drosophila reproductive tract. Front Mol Neurosci. 2024;17 :1374896. doi: 10.3389/fnmol.2024.1374896. PubMed PMID:39156129 PubMed Central PMC11327148.
- Bonanno, SL, Sanfilippo, P, Eamani, A, Sampson, MM, Kandagedon, B, Li, K et al.. Constitutive and Conditional Epitope Tagging of Endogenous G-Protein-Coupled Receptors in Drosophila. J Neurosci. 2024;44 (33):. doi: 10.1523/JNEUROSCI.2377-23.2024. PubMed PMID:38937100 PubMed Central PMC11326870.
- Leuchter, MK, Citrenbaum, C, Wilson, AC, Tibbe, TD, Jackson, NJ, Krantz, DE et al.. The effect of older age on outcomes of rTMS treatment for treatment-resistant depression. Int Psychogeriatr. 2024; :1-6. doi: 10.1017/S1041610224000462. PubMed PMID:38525670 PubMed Central PMC11422516.