Research
Developmental neuropsychology, electrophysiology and molecular genetics
Appointments
- Associate Professor In-Residence, Psychiatry and Biobehavioral Sciences
- Brain Research Institute
- Member, Child and Adolescent Psychiatry
- Genetics & Genomics GPB Home Area
- Neuroscience GPB Home Area
- Faculty, Center for Neurobehavioral Genetics
Biography
Dr. Loo is principal investigator of two NIH grants examining the genetics of electrophysiological (EEG) measurements in attention-deficit/hyperactivity disorder (ADHD). The goal of this work is to define EEG correlates of cognitive and behavioral functioning and use these as ‘refined phenotypes’ to identify risk genes for psychiatric disorder. The long-term goal of this research is to better understand the neural mechanisms by which genetic polymorphisms produce the cognitive and behavioral phenotypes evident in childhood psychiatric disorders.
Dr. Loo’s lab is also studying cognitive and electrophysiological measures as biomarkers for treatment response in ADHD and Tourette’s Disorder. Through collaborations with other neuroscientists, protocols are being developed for the integration of EEG with cognitive and behavioral assays of inhibition and working memory as treatment outcome measures.
Publications
- Wang, X, Ding, L, Sun, S, Loo, SK, Chen, L, Li, T et al.. CASTOR1 : A Novel Tumor Suppressor Linking mTORC1 and KRAS Pathways in Tumorigenesis and Resistance to KRAS-Targeted Therapies in Non-Small Cell Lung Cancer. bioRxiv. 2025; :. doi: 10.1101/2025.04.23.650349. PubMed PMID:40313924 PubMed Central PMC12045348.
- Loo, SK, Feng, J, Reeder, C, Elias, DA, Xu, Z, Huang, Y et al.. Rapid and Sensitive Digital Droplet PCR Assays for Detecting HPV16 DNA in Liquid Biopsies. J Med Virol. 2025;97 (1):e70146. doi: 10.1002/jmv.70146. PubMed PMID:40194910 PubMed Central PMC11683180.
- Wang, L, Yang, W, Zhu, JQ, Huang, YF, Zhong, M, Loo, SKF et al.. Corrigendum to "Sub-chronic toxicity of the active fraction of a modified Huang-Lian-Jie-Du Decoction" [Toxicol. Rep. 13 (2024) 101682]. Toxicol Rep. 2025;14 :101916. doi: 10.1016/j.toxrep.2025.101916. PubMed PMID:39897403 PubMed Central PMC11787664.
- Enders, CK, Vera, JD, Keller, BT, Lenartowicz, A, Loo, SK. Building a simpler moderated nonlinear factor analysis model with Markov Chain Monte Carlo estimation. Psychol Methods. 2024; :. doi: 10.1037/met0000712. PubMed PMID:39666539 .
- Loo, SK, Lenartowicz, A, Norman, LJ, Michelini, G. Translating Decades of Neuroscience Research into Diagnostic and Treatment Biomarkers for ADHD. Adv Neurobiol. 2024;40 :579-616. doi: 10.1007/978-3-031-69491-2_20. PubMed PMID:39562458 .