Intellectual and Developmental Disabilities Research Center

FACULTY

Loo, Sandra K.

Research

Developmental neuropsychology, electrophysiology and molecular genetics

Appointments

  • Associate Professor In-Residence, Psychiatry and Biobehavioral Sciences
  • Brain Research Institute
  • Member, Child and Adolescent Psychiatry
  • Genetics & Genomics GPB Home Area
  • Neuroscience GPB Home Area
  • Faculty, Center for Neurobehavioral Genetics

Biography

Dr. Loo is principal investigator of two NIH grants examining the genetics of electrophysiological (EEG) measurements in attention-deficit/hyperactivity disorder (ADHD). The goal of this work is to define EEG correlates of cognitive and behavioral functioning and use these as ‘refined phenotypes’ to identify risk genes for psychiatric disorder. The long-term goal of this research is to better understand the neural mechanisms by which genetic polymorphisms produce the cognitive and behavioral phenotypes evident in childhood psychiatric disorders.

Dr. Loo’s lab is also studying cognitive and electrophysiological measures as biomarkers for treatment response in ADHD and Tourette’s Disorder. Through collaborations with other neuroscientists, protocols are being developed for the integration of EEG with cognitive and behavioral assays of inhibition and working memory as treatment outcome measures.

Publications

  1. Baweja, R, Faraone, SV, Childress, AC, Weiss, MD, Loo, SK, Wilens, TE et al.. From Consensus Statement to Pills to Pixels: New Innovations in Attention-Deficit/Hyperactivity Disorder Care. J Child Adolesc Psychopharmacol. 2024; :. doi: 10.1089/cap.2024.0022. PubMed PMID:38686563 .
  2. Freichel, R, Zink, N, Chang, FY, Vera, JD, Truong, H, Michelini, G et al.. Alpha event-related decreases during encoding in adults with ADHD - An investigation of sustained attention and working memory processes. Behav Brain Res. 2024;469 :115003. doi: 10.1016/j.bbr.2024.115003. PubMed PMID:38642862 .
  3. Dohrn, MF, Bademci, G, Rebelo, AP, Jeanne, M, Borja, NA, Beijer, D et al.. Recurrent ATP1A1 variant Gly903Arg causes developmental delay, intellectual disability, and autism. Ann Clin Transl Neurol. 2024;11 (4):1075-1079. doi: 10.1002/acn3.51963. PubMed PMID:38504481 PubMed Central PMC11021672.
  4. Pucel, J, Briere, LC, Reuter, C, Gochyyev, P, Undiagnosed Diseases Network, LeBlanc, K et al.. Exome and genome sequencing in a heterogeneous population of patients with rare disease: Identifying predictors of a diagnosis. Genet Med. 2024;26 (6):101115. doi: 10.1016/j.gim.2024.101115. PubMed PMID:38436216 .
  5. Scala, M, Tomati, V, Ferla, M, Lena, M, Cohen, JS, Fatemi, A et al.. De novo variants in DENND5B cause a neurodevelopmental disorder. Am J Hum Genet. 2024;111 (3):529-543. doi: 10.1016/j.ajhg.2024.02.001. PubMed PMID:38387458 PubMed Central PMC10940048.
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