Research
Elucidating the mechanisms of cell fate determination
Appointments
- Associate Professor, Molecular, Cell, and Developmental Biology Member, Cell & Developmental Biology GPB Home Area Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research Gene Regulation GPB Home Area JCCC Cancer and Stem Cell Biology Program Area Neuroscience GPB Home Area
Biography
Elucidating the mechanisms of cell fate determination Mammals have evolved a myriad of methods by which diverse tissues are specified, develop, and then are maintained by stem cells. Our lab is focused on the transcriptional mechanisms that underlie each of these processes to not only understand development, but also cancer, where these processes go awry.
Publications
- Galvan, C, Flores, A, Cerrillos, V, Avila, I, Murphy, C, Zheng, W et al.. Defining metabolic flexibility in hair follicle stem cell induced squamous cell carcinoma. bioRxiv. 2023; :. doi: 10.1101/2023.10.16.562128. PubMed PMID:37905122 PubMed Central PMC10614763.
- Galvan, C, Lowry, WE. Yo-yoing stem cells defy dogma to maintain hair colour. Nature. 2023;616 (7958):666-667. doi: 10.1038/d41586-023-00918-0. PubMed PMID:37076710 .
- Otero-Garcia, M, Mahajani, SU, Wakhloo, D, Tang, W, Xue, YQ, Morabito, S et al.. Molecular signatures underlying neurofibrillary tangle susceptibility in Alzheimer's disease. Neuron. 2022;110 (18):2929-2948.e8. doi: 10.1016/j.neuron.2022.06.021. PubMed PMID:35882228 PubMed Central PMC9509477.
- Mitroi, DN, Tian, M, Kawaguchi, R, Lowry, WE, Carmichael, ST. Single-nucleus transcriptome analysis reveals disease- and regeneration-associated endothelial cells in white matter vascular dementia. J Cell Mol Med. 2022;26 (11):3183-3195. doi: 10.1111/jcmm.17315. PubMed PMID:35543222 PubMed Central PMC9170821.
- Allison, T, Langerman, J, Sabri, S, Otero-Garcia, M, Lund, A, Huang, J et al.. Defining the nature of human pluripotent stem cell-derived interneurons via single-cell analysis. Stem Cell Reports. 2021;16 (10):2548-2564. doi: 10.1016/j.stemcr.2021.08.006. PubMed PMID:34506726 PubMed Central PMC8514853.