Intellectual and Developmental Disabilities Research Center


Micevych, Paul E., Ph.D.


Functional plasticity of steroid sensitive CNS circuits, reproductive behavior and physiology of neurosteroids


  • Professor, Surgery
  • Neurobiology
  • Member, Brain Research Institute
  • Molecular, Cellular & Integrative Physiology GPB Home Area
  • Neuroscience GPB Home Area


Research efforts in the Micevych laboratory involve understanding the cellular and molecular events underlying estrogen action on neurons and glial cells.

In particular they have focused on the role of mu-opioid and nociceptin receptors in the CNS regulation of sexual behavior.

RT-PCR and calcium imaging experiments in neurons and astrocytes have been used to elucidate the mechanisms of estrogen rapid signaling in both glial cells and neurons.


  1. Johnson, CS, Micevych, PE, Mermelstein, PG. Membrane estrogen signaling in female reproduction and motivation. Front Endocrinol (Lausanne). 2022;13 :1009379. doi: 10.3389/fendo.2022.1009379. PubMed PMID:36246891 PubMed Central PMC9557733.
  2. Mohr, MA, Keshishian, T, Falcy, BA, Laham, BJ, Wong, AM, Micevych, PE et al.. Puberty enables oestradiol-induced progesterone synthesis in female mouse hypothalamic astrocytes. J Neuroendocrinol. 2022;34 (6):e13082. doi: 10.1111/jne.13082. PubMed PMID:35000221 PubMed Central PMC9207152.
  3. Chuon, T, Feri, M, Carlson, C, Ondrejik, S, Micevych, PE, Sinchak, K et al.. Progesterone receptor-Src kinase signaling pathway mediates neuroprogesterone induction of the luteinizing hormone surge in female rats. J Neuroendocrinol. 2022;34 (1):e13071. doi: 10.1111/jne.13071. PubMed PMID:34904297 PubMed Central PMC8923351.
  4. Johnson, CS, Hong, W, Micevych, PE. Posterodorsal Medial Amygdala Regulation of Female Social Behavior: GABA versus Glutamate Projections. J Neurosci. 2021;41 (42):8790-8800. doi: 10.1523/JNEUROSCI.1103-21.2021. PubMed PMID:34470806 PubMed Central PMC8528505.
  5. Mohr, MA, Wong, AM, Sukumar, G, Dalgard, CL, Hong, W, Wu, TJ et al.. RNA-sequencing of AVPV and ARH reveals vastly different temporal and transcriptomic responses to estradiol in the female rat hypothalamus. PLoS One. 2021;16 (8):e0256148. doi: 10.1371/journal.pone.0256148. PubMed PMID:34407144 PubMed Central PMC8372949.
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