Research
Heart & Lung Diseases and Stem Cell Biology
Appointments
Associate Professor, Anesthesiology & Perioperative Medicine, Broad Stem Cell Research Center
Biography
Mingxia Gu, MD, PhD, investigates how blood vessels contribute to organ development, disease and regeneration. By leveraging patient-specific stem cell models and advanced bioengineering techniques, she seeks to develop novel, personalized therapies for vascular and cardiopulmonary diseases, including congenital heart and lung defects.
For nearly all children born with a structural heart or lung disease, surgery is the only available therapy. Gu’s research aims to expand therapeutic options by developing new therapies and regenerative approaches that could be administered earlier — before birth.
The vasculature is a dynamic and specialized network essential for organ function, possessing significant plasticity and regenerative potential. Gu investigates how blood vessels influence tissue development, disease progression and healing, with the goal of developing new therapies for vascular-related diseases and advancing organ-regeneration strategies.
A central focus of this research involves generating patient-specific induced pluripotent stem cell-, or iPSC-, derived endothelial and smooth muscle cells, as well as vascularized organoids, to create more accurate disease models. By comparing these iPSC-based models with patient-derived vascular lesion samples, Gu has identified disease-specific cellular changes and mapped transcriptomic and epigenomic alterations at single-cell resolution. Recent efforts have focused on engineering vascularized heart, lung and brain organoids to explore how blood vessels interact with surrounding cells during development and disease.
In addition to illuminating disease mechanisms, Gu leverages a high-throughput drug screening platform paired with machine learning algorithms to identify compounds that can reverse disease pathology in a personalized manner. She is also investigating the signaling pathways that direct tissue-specific endothelial cell fate — the process by which vascular cells take on specialized functions — with the goal of regenerating blood vessel networks in congenital heart and lung defects.
Through a multidisciplinary approach that integrates bioengineering, synthetic biology, stem cell biology and computational modeling, Gu’s research insights could drive advances in vascular medicine and regenerative therapies.
Publications
- Bailey, JE, Mayes, DC, Loisel, GP, Nagayama, T, Aberg, D, Blancard, C et al.. Oxygen Opacity Measurements at High-Energy-Density Conditions. Phys Rev Lett. 2025;135 (20):205101. doi: 10.1103/n2k6-358d. PubMed PMID:41320531 .
- LHAASO Collaboration. Precise measurements of the cosmic ray proton energy spectrum in the "knee" region. Sci Bull (Beijing). 2025; :. doi: 10.1016/j.scib.2025.10.048. PubMed PMID:41314965 .
- Zhang, N, Wang, T, Gu, R, Gu, M. Psychological safety and its influencing factors among elderly patients following traumatic fracture surgery: a cross-sectional study. BMC Geriatr. 2025; :. doi: 10.1186/s12877-025-06709-8. PubMed PMID:41310467 .
- Feng, D, Li, W, Huang, P, Gu, M, Tang, G, Ding, Y et al.. Mechanisms of Microorganisms Alleviating Drought and Salt Stresses in Plants. Microorganisms. 2025;13 (11):. doi: 10.3390/microorganisms13112565. PubMed PMID:41304250 PubMed Central PMC12654186.
- Xu, R, Zhang, S, Chen, J, Gu, M, Du, J, Meng, L et al.. Gait assessment of osteosarcoma patients undergoing total knee arthroplasty: Influence of abduction-adduction angles in knee prostheses. Clin Biomech (Bristol). 2025;131 :106714. doi: 10.1016/j.clinbiomech.2025.106714. PubMed PMID:41289938 .