Intellectual and Developmental Disabilities Research Center


Portera-Cailliau, Carlos, M.D., Ph.D.


Imaging the assembly and plasticity of cortical circuits with two-photon microscopy


  • Associate Professor, Neuroscience IDP
  • Neurology
  • Neurobiology
  • Member, ACCESS Program: Dept. of Neurobiology
  • Brain Research Institute


One research interest is investigation of the mechanisms of synaptogenesis and how dendritic filopodia mature into dendritic spines, which has implications for various neuropsychiatric disorders such as fragile X syndrome.

A second project is aimed at understanding how coordinated neuronal activity arises within developing networks of neurons in cortex.

We are also interested in mechanisms of plasticity and neural repair in peri-infarct cortex after stroke.


  1. Rahmatullah, N, Schmitt, LM, De Stefano, L, Post, S, Robledo, J, Chaudhari, G et al.. Hypersensitivity to Distractors in Fragile X Syndrome from Loss of Modulation of Cortical VIP Interneurons. J Neurosci. 2023;43 (48):8172-8188. doi: 10.1523/JNEUROSCI.0571-23.2023. PubMed PMID:37816596 PubMed Central PMC10697397.
  2. Chari, T, Hernandez, A, Portera-Cailliau, C. A Novel Head-Fixed Assay for Social Touch in Mice Uncovers Aversive Responses in Two Autism Models. J Neurosci. 2023;43 (43):7158-7174. doi: 10.1523/JNEUROSCI.0226-23.2023. PubMed PMID:37669860 PubMed Central PMC10601375.
  3. Goel, A, Cantu, DA, Guilfoyle, J, Chaudhari, GR, Newadkar, A, Todisco, B et al.. Author Correction: Impaired perceptual learning in a mouse model of Fragile X syndrome is mediated by parvalbumin neuron dysfunction and is reversible. Nat Neurosci. 2023;26 (8):1472. doi: 10.1038/s41593-023-01402-8. PubMed PMID:37495675 .
  4. Kourdougli, N, Suresh, A, Liu, B, Juarez, P, Lin, A, Chung, DT et al.. Improvement of sensory deficits in fragile X mice by increasing cortical interneuron activity after the critical period. Neuron. 2023;111 (18):2863-2880.e6. doi: 10.1016/j.neuron.2023.06.009. PubMed PMID:37451263 PubMed Central PMC10529373.
  5. Rahmatullah, N, Schmitt, LM, De Stefano, L, Post, S, Robledo, J, Chaudhari, GR et al.. Hypersensitivity to distractors in Fragile X syndrome from loss of modulation of cortical VIP interneurons. bioRxiv. 2023; :. doi: 10.1101/2023.01.03.522654. PubMed PMID:36711901 PubMed Central PMC9881942.
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