Silva, Alcino J., Ph.D.

Research

Molecular and cellular and systems mechanisms of learning and memory

Appointments

• Distinguished Professor– Neurobiology, Psychiatry & Biobehavioral Sciences and Psychology
• Director–Integrative Center for Learning and Memory
• Tennenbaum Center for the Biology of Creativity
• Brain Research Institute
• Molecular, Cellular & Integrative Physiology GPB Home Area
• Neuroscience GPB Home Area

Biography

The Silva laboratory is studying the biology of learning and memory. They are interested in the molecular, cellular and circuit processes that underlie the allocation, encoding and storage of information. To accomplish this they are using a variety of techniques including sophisticated molecular and genetic approaches, optical physiology, optogenetics, in vivo imaging and behavioral analysis.

Silva and colleagues have also studied the impact of these mechanisms in animal models of cognitive disorders, including intellectual disabilities. Based on these mechanistic studies, they have developed treatments for Neurofibromatosis type I and Tuberous Sclerosis, that are currently being tested in clinical trials.

The Silva laboratory is also developing bioinformatic strategies for tracking and planning experiments (researchmaps.org).

Publications

1. de Assis, EIT, Azevedo, VAN, De Lima Neto, MF, Costa, FC, Paulino, LRFM, Do Monte, APO et al.. Protective in vitro effects of Aloe vera on doxorubicin-induced ovarian toxicity in mice. Biotech Histochem. 2025; :1-12. doi: 10.1080/10520295.2025.2537829. PubMed PMID:40757498 .
2. Lima, JVL, Pessoa, LN, de Souza Neta, MFD, Phanord, JWK, Oliveira, PHA, da Silva, AGC et al.. Synergistic Effect of Exogenous Application of Proline and Boric Acid on the Growth, Physiological Aspects, and Postharvest Quality of Radish under Salt Stress. ACS Omega. 2025;10 (29):31801-31811. doi: 10.1021/acsomega.5c03010. PubMed PMID:40757358 PubMed Central PMC12311737.
3. Sousa, NS, Silva, ALP, Varela Júnior, JJG, Rodrigues, NM. Theoretical Study of SO₂ Selective Detection from the Cr-Modified B₁₂N₁₂. ACS Omega. 2025;10 (29):31789-31800. doi: 10.1021/acsomega.5c02977. PubMed PMID:40757325 PubMed Central PMC12311700.
4. Ávila, DS, Pereira, CMM, Bezerra, IC, Viçozzi, GP, Rosini Silva, AA, da Silva, AJ et al.. Nutritional Supplementation Benefits in under Developmental Disruption and Stress Conditions. ACS Omega. 2025;10 (29):31313-31330. doi: 10.1021/acsomega.4c10748. PubMed PMID:40757322 PubMed Central PMC12311710.
5. de Oliveira, RGB, Yudi, J, da Silva, EP, Bestard, GA, Ribeiro Junior, LA, Silva, AMA et al.. Predicting Porosity in Freeze Casting with Explainable Machine Learning. ACS Omega. 2025;10 (29):32246-32256. doi: 10.1021/acsomega.5c04133. PubMed PMID:40757300 PubMed Central PMC12311858.

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