Research
Molecular and cellular and systems mechanisms of learning and memory
Appointments
- Distinguished Professor– Neurobiology, Psychiatry & Biobehavioral Sciences and Psychology
- Director–Integrative Center for Learning and Memory
- Tennenbaum Center for the Biology of Creativity
- Brain Research Institute
- Molecular, Cellular & Integrative Physiology GPB Home Area
- Neuroscience GPB Home Area
Biography
The Silva laboratory is studying the biology of learning and memory. They are interested in the molecular, cellular and circuit processes that underlie the allocation, encoding and storage of information. To accomplish this they are using a variety of techniques including sophisticated molecular and genetic approaches, optical physiology, optogenetics, in vivo imaging and behavioral analysis.
Silva and colleagues have also studied the impact of these mechanisms in animal models of cognitive disorders, including intellectual disabilities. Based on these mechanistic studies, they have developed treatments for Neurofibromatosis type I and Tuberous Sclerosis, that are currently being tested in clinical trials.
The Silva laboratory is also developing bioinformatic strategies for tracking and planning experiments (researchmaps.org).
Publications
- Sandrasegaran, K, Shah, AS, Thompson, CP, Jayasekara, CR, Carey, EJ, Jain, A et al.. Do hepatic and biliary functional data from gadoxetate-enhanced MRI add value in predicting outcomes in primary sclerosing cholangitis (PSC)?. Eur Radiol. 2026; :. doi: 10.1007/s00330-026-12710-5. PubMed PMID:42363965 .
- Silva, AM, Ferreira Júnior, MA, Cardoso, AIQ, Cury, ERJ, Frota, OP, Azevedo, IC et al.. Analysis of the Cost of Maintaining Effective Donors and Nondonors of Organs and Tissues in Intensive Care Units. Transplant Proc. 2026; :. doi: 10.1016/j.transproceed.2026.06.007. PubMed PMID:42362457 .
- Martinez, EM, Grimes, CA, Bordeaux, BA, Baginski, DM, Langevin, S, Doyle, ME et al.. Automating Ambulatory Central Line Data Capture and Calculations. Appl Clin Inform. 2026;17 (3):476-483. doi: 10.1055/a-2890-1756. PubMed PMID:42361848 .
- Damaceno, C, Silva, ACOD, Saldaña-Serrano, M, Bainy, ACD, Ribeiro, RA, Bauer, AB et al.. Relaying as a complementary management strategy for microplastics, Acanthamoeba spp., and dietary exposure in farmed oysters Magallana gigas (Thunberg, 1793). Mar Pollut Bull. 2026;232 :120066. doi: 10.1016/j.marpolbul.2026.120066. PubMed PMID:42361698 .
- Da Silva, AMP, Gonçalves, OR, Tudella, GCN, Menegucci, G, Klostermann, AU, Valverde, MES et al.. Efficacy and Safety of Perampanel in Patients With Brain Tumor-Related Epilepsy: A Systematic Review and Meta-Analysis. Neurol Clin Pract. 2026;16 (4):e200636. doi: 10.1212/CPJ.0000000000200636. PubMed PMID:42361333 .