Research
Molecular and cellular and systems mechanisms of learning and memory
Appointments
- Distinguished Professor– Neurobiology, Psychiatry & Biobehavioral Sciences and Psychology
- Director–Integrative Center for Learning and Memory
- Tennenbaum Center for the Biology of Creativity
- Brain Research Institute
- Molecular, Cellular & Integrative Physiology GPB Home Area
- Neuroscience GPB Home Area
Biography
The Silva laboratory is studying the biology of learning and memory. They are interested in the molecular, cellular and circuit processes that underlie the allocation, encoding and storage of information. To accomplish this they are using a variety of techniques including sophisticated molecular and genetic approaches, optical physiology, optogenetics, in vivo imaging and behavioral analysis.
Silva and colleagues have also studied the impact of these mechanisms in animal models of cognitive disorders, including intellectual disabilities. Based on these mechanistic studies, they have developed treatments for Neurofibromatosis type I and Tuberous Sclerosis, that are currently being tested in clinical trials.
The Silva laboratory is also developing bioinformatic strategies for tracking and planning experiments (researchmaps.org).
Publications
- Dos Santos, TR, de Oliveira, VC, Cardoso, MA, de Assunção, ML, da Silva, AH, Vieira, RCDS et al.. Study of Nutrition, Health, and Food Security of Indigenous Peoples in the State of Alagoas, Brazil (ENSSAIA): Methodological Aspects. Food Sci Nutr. 2025;13 (12):e71361. doi: 10.1002/fsn3.71361. PubMed PMID:41458893 PubMed Central PMC12741332.
- Silva, ALT, de Barros, BCC, da Silva, JPC, Carvalho, IS, Santoro, ML, Chaves, AFA et al.. Assessing systemic effects of Bothrops jararaca venom in the lungs in a mouse model by label-free proteomics using DDA and DIA. J Proteomics. 2025; :105588. doi: 10.1016/j.jprot.2025.105588. PubMed PMID:41456809 .
- Ortiz-Hernández, EG, Valladolid, I, Silva, A, Luna, A, Guzmán, D, León, M et al.. Supraglottoplasty in severe laryngomalacia: impact on weight gain and symptoms resolution in infants. Bol Med Hosp Infant Mex. 2025;82 (6):369-374. doi: 10.24875/BMHIM.24000169. PubMed PMID:41453191 .
- Lucente, BR, Ribeiro, IC, Santos, LE, Silva, A, Pinheiro, TL, Rizzi, L et al.. Biomarkers. Alzheimers Dement. 2025;21 Suppl 2 (Suppl 2):e104334. doi: 10.1002/alz70856_104334. PubMed PMID:41451978 PubMed Central PMC12742026.
- Albuquerque, RDS, Santos, JBD, Lima, MM, Silva, AOAD, Rossy, KDC, Cunha, MSE et al.. Testicular Assessment in a Selected Group of Young Buffaloes Using Doppler Ultrasonography. Vet Med Sci. 2026;12 (1):e70672. doi: 10.1002/vms3.70672. PubMed PMID:41451977 PubMed Central PMC12742012.