Research
Molecular and cellular and systems mechanisms of learning and memory
Appointments
- Distinguished Professor– Neurobiology, Psychiatry & Biobehavioral Sciences and Psychology
- Director–Integrative Center for Learning and Memory
- Tennenbaum Center for the Biology of Creativity
- Brain Research Institute
- Molecular, Cellular & Integrative Physiology GPB Home Area
- Neuroscience GPB Home Area
Biography
The Silva laboratory is studying the biology of learning and memory. They are interested in the molecular, cellular and circuit processes that underlie the allocation, encoding and storage of information. To accomplish this they are using a variety of techniques including sophisticated molecular and genetic approaches, optical physiology, optogenetics, in vivo imaging and behavioral analysis.
Silva and colleagues have also studied the impact of these mechanisms in animal models of cognitive disorders, including intellectual disabilities. Based on these mechanistic studies, they have developed treatments for Neurofibromatosis type I and Tuberous Sclerosis, that are currently being tested in clinical trials.
The Silva laboratory is also developing bioinformatic strategies for tracking and planning experiments (researchmaps.org).
Publications
- Campos, LR, Carpi, GC, da Silva, ABN, Carneiro, JV, Luchese, S. The impact of remote ischemic preconditioning on postoperative outcomes in pediatric cardiac surgery: an updated systematic review and meta-analysis. Eur J Pediatr. 2025;184 (11):668. doi: 10.1007/s00431-025-06504-y. PubMed PMID:41062871 .
- Maura, F, Bergsagel, PL, Ziccheddu, B, Kumar, S, Maclachlan, K, Derkach, A et al.. Genomics Define Malignant Transformation in Myeloma Precursor Conditions. J Clin Oncol. 2025; :JCO2501733. doi: 10.1200/JCO-25-01733. PubMed PMID:41061199 .
- Arantes, RBB, Silva, AGD, Bessa Correia, MM, Veloso, GA, Lopes Nunes, RM. The Ethics of Care Under Threat: When Protectors Become Perpetrators-Patterns of Abuse and Ethical Breaches by Physicians Accused of Sexual Misconduct in a Brazilian State. Violence Against Women. 2025; :10778012251384624. doi: 10.1177/10778012251384624. PubMed PMID:41061129 .
- Marques, DSC, da Silva, AFF, Lima, LDS, França, WWM, Brayner, FA, Alves, LC et al.. Essential Oil From the Wood of Clarissa racemosa: Chemical Characterization, In Vitro Evaluation of Biological Activities, a Promising Phytopharmaceutical. Chem Biodivers. 2025; :e01435. doi: 10.1002/cbdv.202501435. PubMed PMID:41061023 .
- Loch, MR, Peixoto, SV, Lourenço, BH, Martinez, EZ, Sílva, AAMD. Epidemiology in the Journal Ciência & Saúde Coletiva: analysis of the year 2024. Cien Saude Colet. 2025;30 (9):e12342025. doi: 10.1590/1413-81232025309.12342025. PubMed PMID:41059880 .