Research
Molecular and cellular and systems mechanisms of learning and memory
Appointments
- Distinguished Professor– Neurobiology, Psychiatry & Biobehavioral Sciences and Psychology
- Director–Integrative Center for Learning and Memory
- Tennenbaum Center for the Biology of Creativity
- Brain Research Institute
- Molecular, Cellular & Integrative Physiology GPB Home Area
- Neuroscience GPB Home Area
Biography
The Silva laboratory is studying the biology of learning and memory. They are interested in the molecular, cellular and circuit processes that underlie the allocation, encoding and storage of information. To accomplish this they are using a variety of techniques including sophisticated molecular and genetic approaches, optical physiology, optogenetics, in vivo imaging and behavioral analysis.
Silva and colleagues have also studied the impact of these mechanisms in animal models of cognitive disorders, including intellectual disabilities. Based on these mechanistic studies, they have developed treatments for Neurofibromatosis type I and Tuberous Sclerosis, that are currently being tested in clinical trials.
The Silva laboratory is also developing bioinformatic strategies for tracking and planning experiments (researchmaps.org).
Publications
- Souto, VO, Campos, FM, Sperotto, G, Silva, ALFD, Comparin, SJ, Almeida, RS et al.. Naturally Caffeinated Functional Beverage Based on Grape Juice and Cryoconcentrated Yerba Mate Extract. J Food Sci. 2026;91 (5):e71158. doi: 10.1111/1750-3841.71158. PubMed PMID:42186130 .
- Porto, IM, da Silva, AAS, Dos Santos, JVA, Silva, BM, Giacomin, EB, da Fonseca, GS et al.. Morphological, Histochemical, and Proteomic Analysis of the Effects of Fluoride and Amoxicillin, with Calcium and Vitamin D Supplementation, on Dental Enamel Formation. Calcif Tissue Int. 2026;117 (1):. doi: 10.1007/s00223-026-01548-0. PubMed PMID:42184017 .
- da Silva, AAF, Pereira, MD. Impact of Correcting Skeletal Facial Pattern Types II and III on Quality of Life After Orthognathic Surgery. J Craniofac Surg. 2026; :. doi: 10.1097/SCS.0000000000012754. PubMed PMID:42183621 .
- Silva, AE, Bulin, LAX, Bassani, JC, Valencia, D, Mezalira, DZ, Neiva, EGC et al.. Reduced Graphene Oxide and Nickel Nanoparticle Nanocomposites: Tailoring the Nanoparticle Size for Enhanced Glucose Electrochemical Sensors. ACS Omega. 2026;11 (19):28641-28651. doi: 10.1021/acsomega.6c01043. PubMed PMID:42179614 PubMed Central PMC13191518.
- E Silva, ALAGMDC, Maia Zica, L, Ferreira, DP, Vieira, ACBC, Passos, MD, Silva, AHMM et al.. Perioperative Glycemic Control and Outcomes in Cardiac Surgery: A Retrospective Cohort Study. Med Sci Monit. 2026;32 :e952210. doi: 10.12659/MSM.952210. PubMed PMID:42178741 .