Research
Molecular and cellular and systems mechanisms of learning and memory
Appointments
- Distinguished Professor– Neurobiology, Psychiatry & Biobehavioral Sciences and Psychology
- Director–Integrative Center for Learning and Memory
- Tennenbaum Center for the Biology of Creativity
- Brain Research Institute
- Molecular, Cellular & Integrative Physiology GPB Home Area
- Neuroscience GPB Home Area
Biography
The Silva laboratory is studying the biology of learning and memory. They are interested in the molecular, cellular and circuit processes that underlie the allocation, encoding and storage of information. To accomplish this they are using a variety of techniques including sophisticated molecular and genetic approaches, optical physiology, optogenetics, in vivo imaging and behavioral analysis.
Silva and colleagues have also studied the impact of these mechanisms in animal models of cognitive disorders, including intellectual disabilities. Based on these mechanistic studies, they have developed treatments for Neurofibromatosis type I and Tuberous Sclerosis, that are currently being tested in clinical trials.
The Silva laboratory is also developing bioinformatic strategies for tracking and planning experiments (researchmaps.org).
Publications
- Silva, AR, Bezerra, LGP, Dos Santos, RP, Comizzoli, P. The role of emerging assisted reproductive technologies in the conservation of neotropical wild mammals - challenges, advances and perspectives. J Reprod Dev. 2026;72 (3):196-209. doi: 10.1262/jrd.2025-111. PubMed PMID:42309730 .
- Albuquerque, HMT, Fontes, LFB, Guieu, S, Silva, AMS, Alkorta, I, Elguero, J et al.. The Structures Obtained from the Oxidation of 3-Amino-1H-indazole in Basic Conditions According to Hünig and Pozharskii. J Org Chem. 2026; :. doi: 10.1021/acs.joc.6c00198. PubMed PMID:42307969 .
- Gonçalves, OR, Scarcia, L, Portela, JGS, Santos, GSB, Cardoso, LJC, da Silva, AMP et al.. Tenecteplase Beyond the 4.5-h Window for Patients with Acute Ischemic Stroke: An Updated Meta-Analysis of Randomized Controlled Trials. CNS Drugs. 2026; :. doi: 10.1007/s40263-026-01308-6. PubMed PMID:42307864 .
- Oliveira, ES, Teixeira, IP, Paula, ÍVF, Lacerda, JC, Wanderley Junior, RS, Silva, AAPD et al.. Differences in the microenvironment for leisure physical activity and commuting in São Paulo. Rev Saude Publica. 2026;60 :e21. doi: 10.11606/s1518-8787.2026060006996. PubMed PMID:42307404 .
- Braga, FS, Olschowsky, A, Xavier, MDS, Silva, ABD, Santos, EOD, Nunes, CK et al.. Therapeutic relationships and care in addressing vulnerability in the psychiatric revolving-door phenomenon. Rev Gaucha Enferm. 2026;47 :e20250168. doi: 10.1590/1983-1447.2026.20250168.en. PubMed PMID:42307278 .