Research
Molecular and cellular and systems mechanisms of learning and memory
Appointments
- Distinguished Professor– Neurobiology, Psychiatry & Biobehavioral Sciences and Psychology
- Director–Integrative Center for Learning and Memory
- Tennenbaum Center for the Biology of Creativity
- Brain Research Institute
- Molecular, Cellular & Integrative Physiology GPB Home Area
- Neuroscience GPB Home Area
Biography
The Silva laboratory is studying the biology of learning and memory. They are interested in the molecular, cellular and circuit processes that underlie the allocation, encoding and storage of information. To accomplish this they are using a variety of techniques including sophisticated molecular and genetic approaches, optical physiology, optogenetics, in vivo imaging and behavioral analysis.
Silva and colleagues have also studied the impact of these mechanisms in animal models of cognitive disorders, including intellectual disabilities. Based on these mechanistic studies, they have developed treatments for Neurofibromatosis type I and Tuberous Sclerosis, that are currently being tested in clinical trials.
The Silva laboratory is also developing bioinformatic strategies for tracking and planning experiments (researchmaps.org).
Publications
- Zefa, E, Acosta, RC, Kretschmer, R, Timm, VF, Silva, AFE, Adamoli, JV et al.. A novel multiple sex chromosome system in Orthoptera, found in the tree cricket Oecanthus rubromaculatus Zefa, 2022 (Grylloidea, Oecanthidae). Zootaxa. 2024;5432 (1):109-120. doi: 10.11646/zootaxa.5432.1.8. PubMed PMID:39645795 .
- da Silva, ARP, Costa, MDS, Araújo, NJS, de Freitas, TS, Paulo, CLR, de Alencar, MAS et al.. Evaluation of inhibition and eradication of bacterial biofilm by solasodin. J Steroid Biochem Mol Biol. 2024; :106654. doi: 10.1016/j.jsbmb.2024.106654. PubMed PMID:39645169 .
- Dezordi, FZ, Júnior, JVJS, Ruoso, TF, Batista, AG, Fonseca, PM, Bernardo, LP et al.. Higher frequency of interstate over international transmission chains of SARS-CoV-2 virus at the Rio Grande do Sul - Brazil state borders. Virus Res. 2024; :199500. doi: 10.1016/j.virusres.2024.199500. PubMed PMID:39645167 .
- Filho, RSF, Rebelo, LR, Zanchetin, M, Silva, AS, de Paula, NF, Zervoudakis, JT et al.. Partial replacement of corn grain with levels of crude glycerin on feed intake, digestibility, ruminal fermentation, nitrogen utilization, and performance of feedlot lambs. Trop Anim Health Prod. 2024;56 (9):401. doi: 10.1007/s11250-024-04245-y. PubMed PMID:39641857 .
- da Silva, AGA, de Oliveira Araújo, ME, de Lucena, AML, Fontes, IL, De Lima, ILB, de Souza, PC et al.. Association between consumption of ultra-processed foods and glycemic self-monitoring in women with gestational diabetes mellitus and their newborns: A cohort study. Int J Gynaecol Obstet. 2024; :. doi: 10.1002/ijgo.16047. PubMed PMID:39641631 .