Research
Molecular and cellular and systems mechanisms of learning and memory
Appointments
- Distinguished Professor– Neurobiology, Psychiatry & Biobehavioral Sciences and Psychology
- Director–Integrative Center for Learning and Memory
- Tennenbaum Center for the Biology of Creativity
- Brain Research Institute
- Molecular, Cellular & Integrative Physiology GPB Home Area
- Neuroscience GPB Home Area
Biography
The Silva laboratory is studying the biology of learning and memory. They are interested in the molecular, cellular and circuit processes that underlie the allocation, encoding and storage of information. To accomplish this they are using a variety of techniques including sophisticated molecular and genetic approaches, optical physiology, optogenetics, in vivo imaging and behavioral analysis.
Silva and colleagues have also studied the impact of these mechanisms in animal models of cognitive disorders, including intellectual disabilities. Based on these mechanistic studies, they have developed treatments for Neurofibromatosis type I and Tuberous Sclerosis, that are currently being tested in clinical trials.
The Silva laboratory is also developing bioinformatic strategies for tracking and planning experiments (researchmaps.org).
Publications
- Vieira-Baptista, P, Costa, M, Hippe, J, Sousa, C, Schmitz, M, Silva, AR et al.. Evaluation of Host Gene Methylation as a Triage Test for HPV-Positive Women-A Cohort Study. J Low Genit Tract Dis. 2024; :. doi: 10.1097/LGT.0000000000000830. PubMed PMID:39058311 .
- Merlo, JK, da Silva, AV, Casonatto, J, Ribeiro, AS, de Oliveira Junior, E, do Nascimento, AP et al.. Effects of a Mat Pilates Exercise Program Associated with Photobiomodulation Therapy in Patients with Chronic Nonspecific Low Back Pain: A Randomized, Double-Blind, Sham-Controlled Trial. Healthcare (Basel). 2024;12 (14):. doi: 10.3390/healthcare12141416. PubMed PMID:39057559 .
- Francisco, R, Jesus, F, Santos, P, Trbovšek, P, Moreira, AS, Nunes, C Nunes et al.. Does acute dehydration affect the neuromuscular function in healthy adults? - A systematic review. Appl Physiol Nutr Metab. 2024; :. doi: 10.1139/apnm-2024-0192. PubMed PMID:39047298 .
- Persaud, D, Criscitiello, AS, Spencer, C, Lehnherr, I, Muir, DCG, De Silva, AO et al.. A 50 year record for perfluoroalkyl acids in the high arctic: implications for global and local transport. Environ Sci Process Impacts. 2024; :. doi: 10.1039/d4em00219a. PubMed PMID:39046203 .
- Damascena, LCL, Faria, ARQP, Lucena, NNN, Silva, AHAE, Almeida, TTA, Pinto, DFA et al.. Analysis of factors associated with admission to the intensive care unit of children and adolescents with COVID-19: application of a multilevel model. Crit Care Sci. 2024;36 :e20240068en. doi: 10.62675/2965-2774.20240068-en. PubMed PMID:39046060 PubMed Central PMC11239204.