Research
Molecular and cellular and systems mechanisms of learning and memory
Appointments
- Distinguished Professor– Neurobiology, Psychiatry & Biobehavioral Sciences and Psychology
- Director–Integrative Center for Learning and Memory
- Tennenbaum Center for the Biology of Creativity
- Brain Research Institute
- Molecular, Cellular & Integrative Physiology GPB Home Area
- Neuroscience GPB Home Area
Biography
The Silva laboratory is studying the biology of learning and memory. They are interested in the molecular, cellular and circuit processes that underlie the allocation, encoding and storage of information. To accomplish this they are using a variety of techniques including sophisticated molecular and genetic approaches, optical physiology, optogenetics, in vivo imaging and behavioral analysis.
Silva and colleagues have also studied the impact of these mechanisms in animal models of cognitive disorders, including intellectual disabilities. Based on these mechanistic studies, they have developed treatments for Neurofibromatosis type I and Tuberous Sclerosis, that are currently being tested in clinical trials.
The Silva laboratory is also developing bioinformatic strategies for tracking and planning experiments (researchmaps.org).
Publications
- Pitto, N, Rai, S, Kardaman, N, Adhya, S, D'Silva, A. Complete Heart Block and Nonsustained Ventricular Tachycardia Secondary to Cardiac Metastases From Breast Cancer. JACC Case Rep. 2025; :106404. doi: 10.1016/j.jaccas.2025.106404. PubMed PMID:41364057 .
- Donato, KO, Falcão, L, Silva, RAS, Donato, AO, Nishizima, A, Ribeiro, FV et al.. Efficacy and safety of endoscopic third ventriculostomy with choroid plexus cauterization compared to ventriculoperitoneal shunting in pediatric hydrocephalus: a systematic review and meta-analysis with subgroup analysis. Childs Nerv Syst. 2025;41 (1):410. doi: 10.1007/s00381-025-07043-5. PubMed PMID:41361667 .
- Ventura, BML, Nguema, OGAA, de Carvalho, RL, Pinheiro, PF, da Silva, ADCT, de Godoy, SAM et al.. Evaluation of Antiviral Activity of N‑Phenyl-2-Phenoxyacetamides Derived from Carvacrol against Mayaro Virus: In Vitro Analyses and In Silico Insights. ACS Omega. 2025;10 (47):57085-57096. doi: 10.1021/acsomega.5c05194. PubMed PMID:41358100 PubMed Central PMC12676312.
- Silva, ACB, Esperança, MN, Badino, AC, Béttega, R. CFD Modeling of Shear-Rate Distribution in a Bubble Column Bioreactor: Influence of Bubble Diameter and Lift Force. ACS Omega. 2025;10 (47):57145-57156. doi: 10.1021/acsomega.5c06482. PubMed PMID:41358079 PubMed Central PMC12676301.
- Da Silva, A, Samuriwo, R, Costa, MJ. Editorial: Continuing professional development. Front Med (Lausanne). 2025;12 :1719059. doi: 10.3389/fmed.2025.1719059. PubMed PMID:41357511 PubMed Central PMC12675154.