Research
Molecular and cellular and systems mechanisms of learning and memory
Appointments
- Distinguished Professor– Neurobiology, Psychiatry & Biobehavioral Sciences and Psychology
- Director–Integrative Center for Learning and Memory
- Tennenbaum Center for the Biology of Creativity
- Brain Research Institute
- Molecular, Cellular & Integrative Physiology GPB Home Area
- Neuroscience GPB Home Area
Biography
The Silva laboratory is studying the biology of learning and memory. They are interested in the molecular, cellular and circuit processes that underlie the allocation, encoding and storage of information. To accomplish this they are using a variety of techniques including sophisticated molecular and genetic approaches, optical physiology, optogenetics, in vivo imaging and behavioral analysis.
Silva and colleagues have also studied the impact of these mechanisms in animal models of cognitive disorders, including intellectual disabilities. Based on these mechanistic studies, they have developed treatments for Neurofibromatosis type I and Tuberous Sclerosis, that are currently being tested in clinical trials.
The Silva laboratory is also developing bioinformatic strategies for tracking and planning experiments (researchmaps.org).
Publications
- Vanzela, AS, Silva Pedrollo, LF, Silva, AC, Martin, IDS, da Silva, BP, Dos Santos, MADNB et al.. Barriers and facilitators for self-harm prevention and surveillance: A cross-sectional study with primary health care nurses in Brazil. PLoS One. 2025;20 (12):e0338182. doi: 10.1371/journal.pone.0338182. PubMed PMID:41379821 .
- Souza, AIAF, Lima, CC, Silva, MB, Souza, MC, Silva, AFS, Lacerda, JDA et al.. Population floral polymorphism and the quality of fruits and seeds of Ipomoea cavalcantei D. F. Austin (Convolvulaceae). Braz J Biol. 2025;85 :e293724. doi: 10.1590/1519-6984.293724. PubMed PMID:41379126 .
- Nacul, FE, Bezerra, MB, Gomes, BC, Hohmann, FB, Treml, RE, Caldonazo, T et al.. Current and emerging therapeutic options for refractory septic shock: A systematic review. World J Crit Care Med. 2025;14 (4):111164. doi: 10.5492/wjccm.v14.i4.111164. PubMed PMID:41377532 PubMed Central PMC12687076.
- Pereira, W, Lara, T, Andrade, A, Seruffo, M, Andrade, A, Silva, C et al.. Bioeconomy and Climate Change: The Scenarios of Food Insecurity in Brazil's Northern Region (Amazon) Due to the Shift from Traditional Table Crops to Globally Valued Commodities. Foods. 2025;14 (23):. doi: 10.3390/foods14234146. PubMed PMID:41376083 .
- Correa, LM, Lima, AV, Silva, EGD, Silva, AAFD, Bernardino, MDGDS, Silva, RDS et al.. Hematological and Biochemical Parameters of European Quails (Coturnix coturnix coturnix) Fed Diets with Different Fiber Profiles, with and Without Stimbiotic Inclusion, from 1 to 35 Days. Animals (Basel). 2025;15 (23):. doi: 10.3390/ani15233457. PubMed PMID:41375513 .