Research
Molecular and cellular and systems mechanisms of learning and memory
Appointments
- Distinguished Professor– Neurobiology, Psychiatry & Biobehavioral Sciences and Psychology
- Director–Integrative Center for Learning and Memory
- Tennenbaum Center for the Biology of Creativity
- Brain Research Institute
- Molecular, Cellular & Integrative Physiology GPB Home Area
- Neuroscience GPB Home Area
Biography
The Silva laboratory is studying the biology of learning and memory. They are interested in the molecular, cellular and circuit processes that underlie the allocation, encoding and storage of information. To accomplish this they are using a variety of techniques including sophisticated molecular and genetic approaches, optical physiology, optogenetics, in vivo imaging and behavioral analysis.
Silva and colleagues have also studied the impact of these mechanisms in animal models of cognitive disorders, including intellectual disabilities. Based on these mechanistic studies, they have developed treatments for Neurofibromatosis type I and Tuberous Sclerosis, that are currently being tested in clinical trials.
The Silva laboratory is also developing bioinformatic strategies for tracking and planning experiments (researchmaps.org).
Publications
- Pinto, JN, Pereira, A, Silva, ARR, Cardoso, DN, Mostafaie, A, Campos, F et al.. A Comprehensive Ecotoxicological Evaluation of a Treated Olive Mill Wastewater and Obtained Sludge. Toxics. 2025;13 (8):. doi: 10.3390/toxics13080648. PubMed PMID:40863924 .
- Nunes, GAMA, da Silva, AKA, Faria, RM, Santos, KS, Aguiar, ADC, Barreto Mota da Costa, L et al.. State-of-the-Art Organ-on-Chip Models and Designs for Medical Applications: A Systematic Review. Biomimetics (Basel). 2025;10 (8):. doi: 10.3390/biomimetics10080524. PubMed PMID:40862897 .
- Rodrigues, A, Pina, M, Calisto, R, Leite-Silva, P, Medeiros, P, Silva, C et al.. Characterization of the Population, Treatment Patterns, and Outcomes of Patients with Advanced or Metastatic Non-Small-Cell Lung Cancer (NSCLC) with Epidermal Growth Factor Receptor Mutation (EGFRm): A Retrospective Cohort Study from IPO Porto. Curr Oncol. 2025;32 (8):. doi: 10.3390/curroncol32080414. PubMed PMID:40862783 .
- Lima, LD, Dias, HS, Mendonça, FF, Silva, ASD, Carvalho, BG, Martins, CP et al.. [Between norms and practices: implementation and regional repercussions of changes in primary health care policies in Brazil]. Cad Saude Publica. 2025;41 (8):e00206924. doi: 10.1590/0102-311XPT206924. PubMed PMID:40862446 .
- Pires, RCR, Leal, MDC, Silva, AAMD. Recent temporal trends in cesarean section rates in Brazil according to the Robson classification system. Cad Saude Publica. 2025;41 (8):e00154024. doi: 10.1590/0102-311XEN154024. PubMed PMID:40862440 .