Research
Molecular and cellular and systems mechanisms of learning and memory
Appointments
- Distinguished Professor– Neurobiology, Psychiatry & Biobehavioral Sciences and Psychology
- Director–Integrative Center for Learning and Memory
- Tennenbaum Center for the Biology of Creativity
- Brain Research Institute
- Molecular, Cellular & Integrative Physiology GPB Home Area
- Neuroscience GPB Home Area
Biography
The Silva laboratory is studying the biology of learning and memory. They are interested in the molecular, cellular and circuit processes that underlie the allocation, encoding and storage of information. To accomplish this they are using a variety of techniques including sophisticated molecular and genetic approaches, optical physiology, optogenetics, in vivo imaging and behavioral analysis.
Silva and colleagues have also studied the impact of these mechanisms in animal models of cognitive disorders, including intellectual disabilities. Based on these mechanistic studies, they have developed treatments for Neurofibromatosis type I and Tuberous Sclerosis, that are currently being tested in clinical trials.
The Silva laboratory is also developing bioinformatic strategies for tracking and planning experiments (researchmaps.org).
Publications
- Silva, AMD, Terao, D, Vilela, ESD, Queiroz, SCN, Maia, AHN, Fracarolli, JA et al.. Essential oils on the control of postharvest diseases of papaya. An Acad Bras Cienc. 2025;97 (1):e20240770. doi: 10.1590/0001-3765202520240770. PubMed PMID:40053044 .
- Oliveira, JCS, Galvão, ND, Andrade, ACS, Silva, AMCD. Five-year overall and specific survival of breast cancer in great Cuiaba (MT), Brazil. Rev Bras Epidemiol. 2025;28 :e250010. doi: 10.1590/1980-549720250010. PubMed PMID:40053007 .
- Malta, DC, Bernal, RTI, Silva, AGD, Sá, NNB, Tonaco, LAB, Santos, SLAD et al.. Factors associated with notification of childhood violence in Brazil. Cien Saude Colet. 2025;30 (2):e00572024. doi: 10.1590/1413-81232025302.00572024. PubMed PMID:40052968 .
- Dos Santos, RP, Moreira, SSJ, Bezerra, LGP, Matos, YG, Luz, NRN, Brito, PAP et al.. Short-Term Storage of Collared Peccary Semen in a Transport Container at 5°C Using Different Extenders. Reprod Domest Anim. 2025;60 (3):e70036. doi: 10.1111/rda.70036. PubMed PMID:40052759 .
- Santana, TP, da Silva, ACF, Bastos, MS, Dos Santos Conceição, J, de Souza Khatlab, A, Gasparino, E et al.. Methionine Supplementation of Maternal Diet Improves Hatching Traits, Initial Development, and Performance in Japanese Quail Fed Different Levels of Methionine During Growth. Anim Sci J. 2025;96 (1):e70044. doi: 10.1111/asj.70044. PubMed PMID:40051288 .