Research
Molecular and cellular and systems mechanisms of learning and memory
Appointments
- Distinguished Professor– Neurobiology, Psychiatry & Biobehavioral Sciences and Psychology
- Director–Integrative Center for Learning and Memory
- Tennenbaum Center for the Biology of Creativity
- Brain Research Institute
- Molecular, Cellular & Integrative Physiology GPB Home Area
- Neuroscience GPB Home Area
Biography
The Silva laboratory is studying the biology of learning and memory. They are interested in the molecular, cellular and circuit processes that underlie the allocation, encoding and storage of information. To accomplish this they are using a variety of techniques including sophisticated molecular and genetic approaches, optical physiology, optogenetics, in vivo imaging and behavioral analysis.
Silva and colleagues have also studied the impact of these mechanisms in animal models of cognitive disorders, including intellectual disabilities. Based on these mechanistic studies, they have developed treatments for Neurofibromatosis type I and Tuberous Sclerosis, that are currently being tested in clinical trials.
The Silva laboratory is also developing bioinformatic strategies for tracking and planning experiments (researchmaps.org).
Publications
- Dos Anjos Lima, LA, Maia, MIL, Morais, LKDC, Veríssimo, TNS, Dos Santos, JDC, da Silva, AL et al.. How does the adoption of nutritional plans influence the performance of meat quail during the growth phase in hot environments?. Front Vet Sci. 2024;11 :1469516. doi: 10.3389/fvets.2024.1469516. PubMed PMID:39723179 PubMed Central PMC11669420.
- Harding, C, Clavica, F, Averbeck, MA, Da Silva, A, Drake, MJ, Gajewski, JB et al.. Can We Prevent Recurrent UTIs Without Antibiotics, in Both Those Who Do and Do Not Use Catheters? ICI-RS 2024. Neurourol Urodyn. 2024; :. doi: 10.1002/nau.25641. PubMed PMID:39718154 .
- de Messano, LVR, Gonçalves, JEA, Kassuga, AD, da Silva, AR, Masi, BP, Messano, HF et al.. Updated range distribution of the non-native Asian green mussel Perna viridis (Linnaeus, 1758) at Guanabara Bay, Rio de Janeiro, Brazil. PeerJ. 2024;12 :e18649. doi: 10.7717/peerj.18649. PubMed PMID:39713141 PubMed Central PMC11663401.
- Feitosa, T, Bezerra, L, Silva, AC, Oliveira, D, Mazzetto, S, Cavalcanti, M et al.. New manufacturing technology for rumen-protected fat using Apis mellifera beeswax: yield, characterization, and ruminant feeding. Trop Anim Health Prod. 2024;57 (1):6. doi: 10.1007/s11250-024-04261-y. PubMed PMID:39710808 .
- Santos, MKR, Seghetto, R, Hauptli, L, Paiano, D, da Silva, AS, Benetti Filho, V et al.. Blended phytogenics as an alternative to growth-promoting antibiotics in newly weaned piglets. Trop Anim Health Prod. 2024;57 (1):5. doi: 10.1007/s11250-024-04225-2. PubMed PMID:39710793 .