Research
Molecular and cellular and systems mechanisms of learning and memory
Appointments
- Distinguished Professor– Neurobiology, Psychiatry & Biobehavioral Sciences and Psychology
- Director–Integrative Center for Learning and Memory
- Tennenbaum Center for the Biology of Creativity
- Brain Research Institute
- Molecular, Cellular & Integrative Physiology GPB Home Area
- Neuroscience GPB Home Area
Biography
The Silva laboratory is studying the biology of learning and memory. They are interested in the molecular, cellular and circuit processes that underlie the allocation, encoding and storage of information. To accomplish this they are using a variety of techniques including sophisticated molecular and genetic approaches, optical physiology, optogenetics, in vivo imaging and behavioral analysis.
Silva and colleagues have also studied the impact of these mechanisms in animal models of cognitive disorders, including intellectual disabilities. Based on these mechanistic studies, they have developed treatments for Neurofibromatosis type I and Tuberous Sclerosis, that are currently being tested in clinical trials.
The Silva laboratory is also developing bioinformatic strategies for tracking and planning experiments (researchmaps.org).
Publications
- Magriñá, CS, Sarrasague, MM, Cimato, A, Montañana, LL, Topp, N, Bellida, JI et al.. Organ-specific and time-dependent oxidative damage induced by chronic copper exposure: modulation by vitamin E. Metallomics. 2026; :. doi: 10.1093/mtomcs/mfag023. PubMed PMID:42384034 .
- Kawasaki, ML, Costa, JDS, Vieira, ES, Silva, ACBA, Vani, CRA, Caldeira, ACL et al.. Carbapenemase Genes Surveillance in Pseudomonas aeruginosa From Domestic Animals: A Five-Year Study From Brazil's Midwest Region. Vet Med Int. 2026;2026 :8246667. doi: 10.1155/vmi/8246667. PubMed PMID:42382216 PubMed Central PMC13315122.
- da Silva, ACN, Baila, C. Self-care and the perceived impact of working with people with suicidal ideation on clinical psychologists. Death Stud. 2026; :1-11. doi: 10.1080/07481187.2026.2695287. PubMed PMID:42381197 .
- Dos Santos, AR, de Oliveira, FS, da Silva, AG, Gleriani, JM, Gonçalves, W, Moreira, GL et al.. Retraction notice to "Spatial and temporal distribution of urban heat islands" [Sci. Total Environ. 605-606 (2017) 946-956]. Sci Total Environ. 2026; :181991. doi: 10.1016/j.scitotenv.2026.181991. PubMed PMID:42379917 .
- Silva, JB, Viero, FT, Higa, GSV, Turrini, N, Marques, LB, Carlos, GO et al.. Purinergic-cytokine signaling as a regulatory axis in neuroimmune development. Neuropharmacology. 2026; :111087. doi: 10.1016/j.neuropharm.2026.111087. PubMed PMID:42379470 .