Research
Molecular and cellular and systems mechanisms of learning and memory
Appointments
- Distinguished Professor– Neurobiology, Psychiatry & Biobehavioral Sciences and Psychology
- Director–Integrative Center for Learning and Memory
- Tennenbaum Center for the Biology of Creativity
- Brain Research Institute
- Molecular, Cellular & Integrative Physiology GPB Home Area
- Neuroscience GPB Home Area
Biography
The Silva laboratory is studying the biology of learning and memory. They are interested in the molecular, cellular and circuit processes that underlie the allocation, encoding and storage of information. To accomplish this they are using a variety of techniques including sophisticated molecular and genetic approaches, optical physiology, optogenetics, in vivo imaging and behavioral analysis.
Silva and colleagues have also studied the impact of these mechanisms in animal models of cognitive disorders, including intellectual disabilities. Based on these mechanistic studies, they have developed treatments for Neurofibromatosis type I and Tuberous Sclerosis, that are currently being tested in clinical trials.
The Silva laboratory is also developing bioinformatic strategies for tracking and planning experiments (researchmaps.org).
Publications
- Ziegler, E, Dickson, K, Silva, A, Pirani, S, Tyerman, J, Luctkar-Flude, M et al.. Essential Primary Health Care Skills: Virtual Simulations for Nurse Practitioner Education. Nurse Educ. 2025; :. doi: 10.1097/NNE.0000000000001808. PubMed PMID:39883805 .
- Silva, ACD, Gregorio da Silva, DC, Ferreira, EGC, Abdelnoor, RV, Borém, A, Arias, CA et al.. Genetic diversity, population structure in a historical panel of Brazilian soybean cultivars. PLoS One. 2025;20 (1):e0313151. doi: 10.1371/journal.pone.0313151. PubMed PMID:39883624 .
- Harper, KC, Ronot, M, Wells, ML, Luna, A, Ba-Ssalamah, A, Wang, J et al.. Hypointense Findings on Hepatobiliary Phase MR Images. Radiographics. 2025;45 (2):e240090. doi: 10.1148/rg.240090. PubMed PMID:39883575 .
- Silva, A, Monteiro, N, Mateia, E, Santos, I, Correia, M. Cutaneous Metastasis in Advanced Gastric Cancer. Acta Med Port. 2025; :. doi: 10.20344/amp.22555. PubMed PMID:39882740 .
- Minayo, MCS, Gomes, R, Silva, AAMD. Ciência & Saúde Coletiva, National and International Science. Cien Saude Colet. 2025;30 (1):e16042024. doi: 10.1590/1413-81232025301.16042024. PubMed PMID:39879470 .