Intellectual and Developmental Disabilities Research Center

FACULTY

Sofroniew, Michael V., M.D., Ph.D.

Research

Neural injury and repair

Appointments

  • Professor, Neurobiology
  • Member, Brain Research Institute
  • CTSI
  • Neuroengineering Training Program
  • Neuroscience GPB Home Area

Biography

Our work is directed at achieving a better understanding of the cell biology of the response to injury in the adult central nervous system.

We are particularly interested in the roles played by specific cell types (e.g. astroglia) and specific molecules (e.g. growth factors and cytokines) in mediating neuroprotection, regulating inflammation and determining the capacity for regeneration.

Our studies are based largely on systems-level analysis in transgenic mouse models. Specific techniques employed include microsurgery, tissue culture, grafting (also from precursor cells and genetically modified cells), immunohistochemistry, tract-tracing, quantitative morphometry, and various molecular biological techniques associated with generating, maintaining, and evaluating transgenic mice.

Publications

  1. Sofroniew, MV. Astrocyte cells in the brain have immune memory. Nature. 2024;627 (8005):744-745. doi: 10.1038/d41586-024-00676-7. PubMed PMID:38509288 .
  2. Liddelow, SA, Olsen, ML, Sofroniew, MV. Reactive Astrocytes and Emerging Roles in Central Nervous System (CNS) Disorders. Cold Spring Harb Perspect Biol. 2024; :. doi: 10.1101/cshperspect.a041356. PubMed PMID:38316554 .
  3. Gleichman, AJ, Kawaguchi, R, Sofroniew, MV, Carmichael, ST. A toolbox of astrocyte-specific, serotype-independent adeno-associated viral vectors using microRNA targeting sequences. Nat Commun. 2023;14 (1):7426. doi: 10.1038/s41467-023-42746-w. PubMed PMID:37973910 PubMed Central PMC10654773.
  4. Verkhratsky, A, Butt, A, Li, B, Illes, P, Zorec, R, Semyanov, A et al.. Astrocytes in human central nervous system diseases: a frontier for new therapies. Signal Transduct Target Ther. 2023;8 (1):396. doi: 10.1038/s41392-023-01628-9. PubMed PMID:37828019 PubMed Central PMC10570367.
  5. Squair, JW, Milano, M, de Coucy, A, Gautier, M, Skinnider, MA, James, ND et al.. Recovery of walking after paralysis by regenerating characterized neurons to their natural target region. Science. 2023;381 (6664):1338-1345. doi: 10.1126/science.adi6412. PubMed PMID:37733871 .
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