Research
Molecular pathogenesis of human CNS disease, including dementia, parenchymal substrates of epilepsy, and stroke/cerebrovascular disease
Appointments
- Chief, Neuropathology
- Professor, Neurology
- Pathology and Laboratory Medicine
- Autopsy
- Surgical Pathology
- Member, ACCESS Program: Dept. of Cellular & Molecular Pathology
- Brain Research Institute
- Faculty, Cellular and Molecular Pathology PhD Program
Biography
Vinters work on pediatric epilepsy continues to focus on characterizing expression (with brain and viscera) of genes associated with known familial syndromes of cortical malformation. Emphasis has been placed on the study of two genes which are frequently mutated to yield the (epilepsy-associated) condition tuberous sclerosis, i.e. TSC1 on chromosome 9q34 (protein product hamartin) and TSC2 on chromosome 16p13.3 (protein product tuberin).
Vinters lab is also studying subcellular localization, translocation and molecular mechanisms of action of tuberin/hamartin using tissue culture models.
Publications
- Zhang, D, Tsai, K, Santana, C, Javaherian, K, Lee, M, Bergsneider, M et al.. Genetic Profiling of Synchronous Pituitary Corticotroph Adenomas. Res Sq. 2025; :. doi: 10.21203/rs.3.rs-6356485/v1. PubMed PMID:40386408 PubMed Central PMC12083677.
- Pan, H, Balbirnie, M, Hou, K, Sta Maria, NS, Sahay, S, Denver, P et al.. Liganded magnetic nanoparticles for magnetic resonance imaging of α-synuclein. NPJ Parkinsons Dis. 2025;11 (1):88. doi: 10.1038/s41531-025-00918-z. PubMed PMID:40268938 PubMed Central PMC12019173.
- Kim, H, Lee, J, Qian, A, Ji, YR, Zhang, R, Hu, Q et al.. Noninvasive Assessment of β-Secretase Activity Through Click Chemistry-Mediated Enrichment of Neuronal Extracellular Vesicles to Detect Alzheimer's Disease. Adv Sci (Weinh). 2025; :e2415289. doi: 10.1002/advs.202415289. PubMed PMID:40245252 .
- Chang, X, Tse, AM, Fayzullina, M, Albanese, A, Kim, M, Wang, CF et al.. Monoaminergic neurotransmitters are bimodal effectors of tau aggregation. Sci Adv. 2025;11 (5):eadr8055. doi: 10.1126/sciadv.adr8055. PubMed PMID:39888993 PubMed Central PMC11784839.
- Janilkarn-Urena, I, Tse, A, Lin, J, Tafolla-Aguirre, B, Idrissova, A, Zhang, M et al.. Improving the solubility of pseudo-hydrophobic chemicals through co-crystal formulation. PNAS Nexus. 2025;4 (1):pgaf007. doi: 10.1093/pnasnexus/pgaf007. PubMed PMID:39850078 PubMed Central PMC11756387.