Research
Molecular pathogenesis of human CNS disease, including dementia, parenchymal substrates of epilepsy, and stroke/cerebrovascular disease
Appointments
- Chief, Neuropathology
- Professor, Neurology
- Pathology and Laboratory Medicine
- Autopsy
- Surgical Pathology
- Member, ACCESS Program: Dept. of Cellular & Molecular Pathology
- Brain Research Institute
- Faculty, Cellular and Molecular Pathology PhD Program
Biography
Vinters work on pediatric epilepsy continues to focus on characterizing expression (with brain and viscera) of genes associated with known familial syndromes of cortical malformation. Emphasis has been placed on the study of two genes which are frequently mutated to yield the (epilepsy-associated) condition tuberous sclerosis, i.e. TSC1 on chromosome 9q34 (protein product hamartin) and TSC2 on chromosome 16p13.3 (protein product tuberin).
Vinters lab is also studying subcellular localization, translocation and molecular mechanisms of action of tuberin/hamartin using tissue culture models.
Publications
- Zhang, T, Li, Y, Pan, L, Sha, J, Bailey, M, Faure-Kumar, E et al.. Brain-wide alterations revealed by spatial transcriptomics and proteomics in COVID-19 infection. Nat Aging. 2024;4 (11):1598-1618. doi: 10.1038/s43587-024-00730-z. PubMed PMID:39543407 .
- Wang, J, Williams, CK, DeTure, MA, Magaki, SD, Dickson, DW, Vinters, HV et al.. Tau seeds catalyze fibril-type structures from GFP tau biosensor cells. Structure. 2024; :. doi: 10.1016/j.str.2024.10.013. PubMed PMID:39488204 .
- Kovacs, GG, Katsumata, Y, Wu, X, Aung, KZ, Fardo, DW, Forrest, SL et al.. Amyloid-β predominant Alzheimer's disease neuropathologic change. Brain. 2024; :. doi: 10.1093/brain/awae325. PubMed PMID:39417691 .
- Zhang, D, Hugo, W, Bergsneider, M, Wang, MB, Kim, W, Han, K et al.. Cabergoline targets multiple pathways to inhibit PRL secretion and increases stromal fibrosis. Eur J Endocrinol. 2024;190 (6):467-478. doi: 10.1093/ejendo/lvae055. PubMed PMID:38781434 .
- Tian, M, Kawaguchi, R, Shen, Y, Machnicki, M, Villegas, NG, Cooper, DR et al.. Intercellular Signaling Pathways as Therapeutic Targets for Vascular Dementia Repair. bioRxiv. 2024; :. doi: 10.1101/2024.03.24.585301. PubMed PMID:38585718 PubMed Central PMC10996514.