Research
Molecular pathogenesis of human CNS disease, including dementia, parenchymal substrates of epilepsy, and stroke/cerebrovascular disease
Appointments
- Chief, Neuropathology
- Professor, Neurology
- Pathology and Laboratory Medicine
- Autopsy
- Surgical Pathology
- Member, ACCESS Program: Dept. of Cellular & Molecular Pathology
- Brain Research Institute
- Faculty, Cellular and Molecular Pathology PhD Program
Biography
Vinters work on pediatric epilepsy continues to focus on characterizing expression (with brain and viscera) of genes associated with known familial syndromes of cortical malformation. Emphasis has been placed on the study of two genes which are frequently mutated to yield the (epilepsy-associated) condition tuberous sclerosis, i.e. TSC1 on chromosome 9q34 (protein product hamartin) and TSC2 on chromosome 16p13.3 (protein product tuberin).
Vinters lab is also studying subcellular localization, translocation and molecular mechanisms of action of tuberin/hamartin using tissue culture models.
Publications
- EADB, EADI, Bonn, ADGC, CHARGE, FinnGen et al.. Consensus meta-analysis of genome-wide association studies for Alzheimer's disease and related dementias. Nat Genet. 2026; :. doi: 10.1038/s41588-026-02583-1. PubMed PMID:42237039 .
- Xu, H, Nanda, S, Sun, J, Rudd, M, Gou, L, Marks, H et al.. Investigation of the myelin-amyloid interplay in Alzheimer's disease: insights from novel dsCMA imaging in mouse and human brains. Acta Neuropathol Commun. 2026; :. doi: 10.1186/s40478-026-02317-8. PubMed PMID:42135869 .
- Quinones-Valdez, G, Chang, JW, Magaki, SD, Vinters, HV, Salamon, N, Wang, AC et al.. Immune landscape of the affected brain in Rasmussen encephalitis. Sci Rep. 2026; :. doi: 10.1038/s41598-026-51295-3. PubMed PMID:42129303 .
- Contreras, AG, Walters, S, Eissman, JM, Archer, DB, Regelson, AN, Durant, A et al.. Genetic modifiers of APOE-ε4-associated cognitive decline. Nat Commun. 2026;17 (1):. doi: 10.1038/s41467-026-68933-z. PubMed PMID:41720779 PubMed Central PMC13036010.
- Pan, H, Cheng, X, Zhang, J, Hou, K, Murray, KA, Manglani, K et al.. In Vitro and In Vivo Evaluation of Small-Molecule Disassemblers of Pathological Tau Fibrils. ACS Chem Neurosci. 2026;17 (2):450-464. doi: 10.1021/acschemneuro.5c00940. PubMed PMID:41486697 .