Research
Molecular pathogenesis of human CNS disease, including dementia, parenchymal substrates of epilepsy, and stroke/cerebrovascular disease
Appointments
- Chief, Neuropathology
- Professor, Neurology
- Pathology and Laboratory Medicine
- Autopsy
- Surgical Pathology
- Member, ACCESS Program: Dept. of Cellular & Molecular Pathology
- Brain Research Institute
- Faculty, Cellular and Molecular Pathology PhD Program
Biography
Vinters work on pediatric epilepsy continues to focus on characterizing expression (with brain and viscera) of genes associated with known familial syndromes of cortical malformation. Emphasis has been placed on the study of two genes which are frequently mutated to yield the (epilepsy-associated) condition tuberous sclerosis, i.e. TSC1 on chromosome 9q34 (protein product hamartin) and TSC2 on chromosome 16p13.3 (protein product tuberin).
Vinters lab is also studying subcellular localization, translocation and molecular mechanisms of action of tuberin/hamartin using tissue culture models.
Publications
- Chang, X, Tse, AM, Fayzullina, M, Albanese, A, Kim, M, Wang, CF et al.. Monoaminergic neurotransmitters are bimodal effectors of tau aggregation. Sci Adv. 2025;11 (5):eadr8055. doi: 10.1126/sciadv.adr8055. PubMed PMID:39888993 PubMed Central PMC11784839.
- Janilkarn-Urena, I, Tse, A, Lin, J, Tafolla-Aguirre, B, Idrissova, A, Zhang, M et al.. Improving the solubility of pseudo-hydrophobic chemicals through co-crystal formulation. PNAS Nexus. 2025;4 (1):pgaf007. doi: 10.1093/pnasnexus/pgaf007. PubMed PMID:39850078 PubMed Central PMC11756387.
- Zhang, J, Argueta, D, Tong, X, Vinters, HV, Mathern, GW, Cepeda, C et al.. Iconography of abnormal non-neuronal cells in pediatric focal cortical dysplasia type IIb and tuberous sclerosis complex. Front Cell Neurosci. 2024;18 :1486315. doi: 10.3389/fncel.2024.1486315. PubMed PMID:39835291 PubMed Central PMC11743721.
- Nouri, MN, Dropol, A, Tyrrell, PN, Sheikh, S, Twilt, M, Michaud, J et al.. Towards a histological diagnosis of childhood small vessel CNS vasculitis. Pediatr Rheumatol Online J. 2024;22 (1):111. doi: 10.1186/s12969-024-01053-4. PubMed PMID:39732702 PubMed Central PMC11682624.
- Lauzier, DC, Vinters, HV, Magaki, SD. Microglia and macrophages in brain injury and repair after subarachnoid hemorrhage. Neural Regen Res. 2024; :. doi: 10.4103/NRR.NRR-D-24-01037. PubMed PMID:39665792 .