Wiedau-Pazos, Martina, Ph.D.

Research

Seeks to discover mechanisms that underlie the degeneration of motor neurons, how these systems can go awry in ALS, and how new therapies can be developed

Appointments

• Associate Professor, Neurology
• Member, Brain Research Institute
• Center for Duchenne Muscular Dystrophy

Biography

Dr. Wiedau-Pazos specializes in clinical care for ALS (also known as Lou Gehrig’s disease) patients and heads the ALS research laboratory at the UCLA Department of Neurology. She seeks to discover mechanisms that underlie the degeneration of motor neurons, how these systems can go awry in ALS, and how new therapies can be developed.

Publications

1. Brooks, BR, Heiman-Patterson, T, Wiedau-Pazos, M, Liu, S, Zhang, J, Apple, S et al.. Edaravone efficacy in amyotrophic lateral sclerosis with reduced forced vital capacity: Post-hoc analysis of Study 19 (MCI186-19) [clinical trial NCT01492686]. PLoS One. 2022;17 (6):e0258614. doi: 10.1371/journal.pone.0258614. PubMed PMID:35700157 PubMed Central PMC9197041.
2. Jensen, S, Hafer, J, Wiedau-Pazos, M, Mehta, AK. Longitudinal specialty palliative care for people with amyotrophic lateral sclerosis using a universal referral method. Muscle Nerve. 2022;66 (2):E5-E6. doi: 10.1002/mus.27562. PubMed PMID:35470443 .
3. van Rheenen, W, van der Spek, RAA, Bakker, MK, van Vugt, JJFA, Hop, PJ, Zwamborn, RAJ et al.. Author Correction: Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology. Nat Genet. 2022;54 (3):361. doi: 10.1038/s41588-022-01020-3. PubMed PMID:35102318 PubMed Central PMC8920884.
4. van Rheenen, W, van der Spek, RAA, Bakker, MK, van Vugt, JJFA, Hop, PJ, Zwamborn, RAJ et al.. Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology. Nat Genet. 2021;53 (12):1636-1648. doi: 10.1038/s41588-021-00973-1. PubMed PMID:34873335 PubMed Central PMC8648564.
5. Hafer, J, Jensen, S, Wiedau-Pazos, M, Mehta, AK. Assessment of feasibility and utility of universal referral to specialty palliative care in a multidisciplinary amyotrophic lateral sclerosis clinic: A cohort study. Muscle Nerve. 2021;63 (6):818-823. doi: 10.1002/mus.27194. PubMed PMID:33533539 .

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