Intellectual and Developmental Disabilities Research Center

FACULTY

Wong, Derek A., M.D.

Research

Patients with inborn errors of metabolism

Appointments

  • Pediatrics
  • Genetics

Biography

Dr Wong sees patients with genetic disorders, and has a special interest in patients with inborn errors of metabolism.

His clinical and research interests include newborn screening, clinical trials for new therapies for inborn errors of metabolism, and mathematical and computer modeling of biologic processes.

Publications

  1. DeWinter, MA, Wong, DA, Fernandez, R, Kightlinger, W, Thames, AH, DeLisa, MP et al.. Establishing a Cell-Free Glycoprotein Synthesis System for Enzymatic N-GlcNAcylation. ACS Chem Biol. 2024;19 (7):1570-1582. doi: 10.1021/acschembio.4c00228. PubMed PMID:38934647 .
  2. Thames, AH, Moons, SJ, Wong, DA, Boltje, TJ, Bochner, BS, Jewett, MC et al.. GlycoCAP: A Cell-Free, Bacterial Glycosylation Platform for Building Clickable Azido-Sialoglycoproteins. ACS Synth Biol. 2023;12 (4):1264-1274. doi: 10.1021/acssynbio.3c00017. PubMed PMID:37040463 PubMed Central PMC10758250.
  3. Williams, AJ, Warfel, KF, Desai, P, Li, J, Lee, JJ, Wong, DA et al.. A low-cost recombinant glycoconjugate vaccine confers immunogenicity and protection against enterotoxigenic Escherichia coli infections in mice. Front Mol Biosci. 2023;10 :1085887. doi: 10.3389/fmolb.2023.1085887. PubMed PMID:36936989 PubMed Central PMC10018396.
  4. Warfel, KF, Williams, A, Wong, DA, Sobol, SE, Desai, P, Li, J et al.. A Low-Cost, Thermostable, Cell-Free Protein Synthesis Platform for On-Demand Production of Conjugate Vaccines. ACS Synth Biol. 2023;12 (1):95-107. doi: 10.1021/acssynbio.2c00392. PubMed PMID:36548479 PubMed Central PMC9872175.
  5. Wong, DA. Findings from the Study of Early Bed Rest for Thoracolumbar Compression Fractures Has Applications Across Health Systems: Commentary on an article by Toru Funayama, MD, PhD, et al.: "Therapeutic Effects of Conservative Treatment with 2-Week Bed Rest for Osteoporotic Vertebral Fractures. A Prospective Cohort Study". J Bone Joint Surg Am. 2022;104 (20):e89. doi: 10.2106/JBJS.22.00841. PubMed PMID:36260049 .
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