Research
Mouse molecular genetics are used to study the pathogenesis and develop treatment for neurodegenerative diseases
Appointments
- Professor, Psychiatry and Biobehavioral Sciences
Biography
Yang is interested in using the mouse genetic approach to study the pathogenesis and to identify potential therapeutic strategies for neurodegenerative diseases, particularly for Huntington’s Disease (HD) and Parkinson’s Disease (PD).
Yang and his colleagues focus on the following projects:
- in order to understand how mutant Huntington acts to result in a wide variety of clinical symptoms ranging from psychiatric, cognitive to motor deficits, they generate and analyze brain regional-specific models of HD in mice
- they take advantage of the high-speed BAC transgenic system to systematically test candidate dominant genetic modifiers of HD in mice.
- they use BAC transgenesis to introduce known PD mutations into mice to develop mouse models for Parkinson’s Disease
Publications
- Zhang, M, Wu, TZ, Wang, JJ, Yu, HY, Zhang, JH, Meng, DL et al.. Quinazolinone nitriles and related metabolites from the deep-sea-derived fungus Penicillium viridicatum MCCC 3A00265. Org Biomol Chem. 2024; :. doi: 10.1039/d4ob01795a. PubMed PMID:39716919 .
- Duan, JX, Ma, YL, Chen, ZW, Zou, ZB, Chao, R, Li, Y et al.. Chemical Constituents of the Deep-sea Derived Fungus Purpureocillium lilacinum XIA-9. Chem Biodivers. 2024; :e202402766. doi: 10.1002/cbdv.202402766. PubMed PMID:39549042 .
- Zou, ZB, Li, JY, Wang, Y, Xie, CL, Dong, HY, Zhang, M et al.. Nigenolides A-H, 13 new microperfuranones with ferroptosis inhibitory activity from the deep-sea-derived Aspergillus niger. Bioorg Chem. 2024;153 :107919. doi: 10.1016/j.bioorg.2024.107919. PubMed PMID:39509787 .
- Park, CS, Yan, M, Zhu, M, Akram, MA, Foster, NN, Bennecke, A et al.. Dendritome Mapping Unveils Spatial Organization of Striatal D1/D2-Neuron Morphology. bioRxiv. 2024; :. doi: 10.1101/2024.10.24.619934. PubMed PMID:39484488 PubMed Central PMC11526962.
- Wu, YT, Ru, ZQ, Peng, Y, Fu, Z, Jia, QY, Kang, ZJ et al.. Peptide Cy RL-QN15 accelerates hair regeneration in diabetic mice by binding to the Frizzled-7 receptor. Zool Res. 2024;45 (6):1287-1299. doi: 10.24272/j.issn.2095-8137.2024.134. PubMed PMID:39479995 PubMed Central PMC11668943.