Research
Mouse molecular genetics are used to study the pathogenesis and develop treatment for neurodegenerative diseases
Appointments
- Professor, Psychiatry and Biobehavioral Sciences
Biography
Yang is interested in using the mouse genetic approach to study the pathogenesis and to identify potential therapeutic strategies for neurodegenerative diseases, particularly for Huntington’s Disease (HD) and Parkinson’s Disease (PD).
Yang and his colleagues focus on the following projects:
- in order to understand how mutant Huntington acts to result in a wide variety of clinical symptoms ranging from psychiatric, cognitive to motor deficits, they generate and analyze brain regional-specific models of HD in mice
- they take advantage of the high-speed BAC transgenic system to systematically test candidate dominant genetic modifiers of HD in mice.
- they use BAC transgenesis to introduce known PD mutations into mice to develop mouse models for Parkinson’s Disease
Publications
- Wang, YJ, Shi, XY, Guo, Y, Wang, XN, Zheng, KX, Yang, XW et al.. Macroscopic Gold Cluster Helical Tendrils. J Am Chem Soc. 2025; :. doi: 10.1021/jacs.4c17800. PubMed PMID:39882669 .
- Song, YF, Wang, Y, Zou, ZB, Chao, R, Wu, TZ, Zhong, TH et al.. Chemical Constituents of the Deep-Sea-Derived Fungus Trichoderma simmonsii ZEN3. Chem Biodivers. 2025; :e202500135. doi: 10.1002/cbdv.202500135. PubMed PMID:39865416 .
- Xu, ZH, Xie, MM, Xie, CL, Yang, XW, Wang, JS. Deep-Sea-Derived Isobisvertinol Targets TLR4 to Exhibit Neuroprotective Activity via Anti-Inflammatory and Ferroptosis-Inhibitory Effects. Mar Drugs. 2025;23 (1):. doi: 10.3390/md23010049. PubMed PMID:39852551 PubMed Central PMC11766622.
- Zou, ZB, Ma, YL, Li, Y, Nie, SS, Li, Y, Xie, CL et al.. Chemical Constituents of the Deep-Sea-Derived Penicillium citrinum W22 and Their Ferroptosis Inhibitory Activity. Chem Biodivers. 2025; :e202403319. doi: 10.1002/cbdv.202403319. PubMed PMID:39823261 .
- Li, C, Zhang, XY, Wu, YH, Yang, XL, Yu, HR, Jin, HB et al.. [Expert consensus on ethical requirements for artificial intelligence (AI) processing medical data]. Sheng Li Xue Bao. 2024;76 (6):937-942. . PubMed PMID:39780570 .