Research
Mouse molecular genetics are used to study the pathogenesis and develop treatment for neurodegenerative diseases
Appointments
- Professor, Psychiatry and Biobehavioral Sciences
Biography
Yang is interested in using the mouse genetic approach to study the pathogenesis and to identify potential therapeutic strategies for neurodegenerative diseases, particularly for Huntington’s Disease (HD) and Parkinson’s Disease (PD).
Yang and his colleagues focus on the following projects:
- in order to understand how mutant Huntington acts to result in a wide variety of clinical symptoms ranging from psychiatric, cognitive to motor deficits, they generate and analyze brain regional-specific models of HD in mice
- they take advantage of the high-speed BAC transgenic system to systematically test candidate dominant genetic modifiers of HD in mice.
- they use BAC transgenesis to introduce known PD mutations into mice to develop mouse models for Parkinson’s Disease
Publications
- Nie, SS, Yang, TJ, Zou, ZB, Chen, DL, Zhang, JM, Xu, JY et al.. Anti-fungal Compounds from the Deep-Sea-Derived Tritirachium oryzae Inhibited Phytophthora nicotianae by Blocking TCA Cycle. Chem Biodivers. 2025; :e202501151. doi: 10.1002/cbdv.202501151. PubMed PMID:40243286 .
- Tang, B, Qu, QC, Cun, DY, Yang, XW, Su, K, Zou, RC et al.. WWOX attenuates the progression of gallbladder cancer by suppressing cellular glycolysis through the modulation of the P73/HIF-1α signaling pathway. Tissue Cell. 2025;95 :102885. doi: 10.1016/j.tice.2025.102885. PubMed PMID:40198927 .
- Xie, CL, Ye, SH, Yue, YT, Shi, BH, Xu, JP, Li, LJ et al.. Viridicatol from the Deep-Sea-Derived Fungus Alleviates Bone Loss by Targeting the Wnt/SHN3 Pathway. Adv Sci (Weinh). 2025; :e2416140. doi: 10.1002/advs.202416140. PubMed PMID:40192033 .
- Deng, MH, Yang, XW, Zhou, YM, Xie, LZ, Zou, T, Ping, JG et al.. In silico research of coagulation- and fibrinolysis-related genes for predicting prognosis of clear cell renal cell carcinoma. Transl Androl Urol. 2025;14 (2):307-324. doi: 10.21037/tau-24-483. PubMed PMID:40114841 PubMed Central PMC11921444.
- Chen, ZW, Wang, Y, Chao, R, Wu, TZ, Zhong, TH, Yang, XW et al.. Chemical Constituents with Ferroptosis Inhibitory Activity of the Deep-Sea-Derived Penicillium paxilli. Chem Biodivers. 2025; :e202500540. doi: 10.1002/cbdv.202500540. PubMed PMID:40106372 .