Research
Mouse molecular genetics are used to study the pathogenesis and develop treatment for neurodegenerative diseases
Appointments
- Professor, Psychiatry and Biobehavioral Sciences
Biography
Yang is interested in using the mouse genetic approach to study the pathogenesis and to identify potential therapeutic strategies for neurodegenerative diseases, particularly for Huntington’s Disease (HD) and Parkinson’s Disease (PD).
Yang and his colleagues focus on the following projects:
- in order to understand how mutant Huntington acts to result in a wide variety of clinical symptoms ranging from psychiatric, cognitive to motor deficits, they generate and analyze brain regional-specific models of HD in mice
- they take advantage of the high-speed BAC transgenic system to systematically test candidate dominant genetic modifiers of HD in mice.
- they use BAC transgenesis to introduce known PD mutations into mice to develop mouse models for Parkinson’s Disease
Publications
- Wang, LX, Shi, SJ, Long, LP, He, XP, Peng-Zhang,, Yang, XW et al.. Anti-inflammatory oxazole-, nitro- and hexahydropyrrolo[2,1-b]oxazole-containing abietane diterpenoid alkaloids from Salvia miltiorrhiza. Phytochemistry. 2024; :114300. doi: 10.1016/j.phytochem.2024.114300. PubMed PMID:39414123 .
- Wu, BY, Ren, ZZ, Liu, Y, Yang, XW, Zhang, YW. [A case of giant hilar cholangiocarcinoma accompanied by hyperbilirubinemia achieved disease stabilization via hepatic artery infusion chemotherapy combined with targeted therapy]. Zhonghua Gan Zang Bing Za Zhi. 2024;32 (9):845-849. doi: 10.3760/cma.j.cn501113-20231014-00143. PubMed PMID:39375106 .
- Cao, JH, Wu, KF, Li, GX, Chen, J, Mu, ZH, Li, HM et al.. Efficacy of Double-Lumen Biliary-Enteric Tube in Enteral Nutrition for Patients with Malignant Obstructive Jaundice. Nutr Cancer. 2024; :1-10. doi: 10.1080/01635581.2024.2408041. PubMed PMID:39327695 .
- Hu, H, Zhu, Q, Tang, H, Zhang, SC, Huang, YZ, Wang, YF et al.. The risk of treatment-related toxicities with PD-1/PD-L1 inhibitors in patients with lung cancer. Int J Cancer. 2024; :. doi: 10.1002/ijc.35195. PubMed PMID:39319530 .
- Wang, X, Wu, W, Yang, G, Yang, XW, Ma, X, Zhu, DD et al.. Cell-specific Nav1.6 knockdown reduced astrocyte-derived Aβ by reverse Na+-Ca2+ transporter-mediated autophagy in alzheimer-like mice. J Adv Res. 2024; :. doi: 10.1016/j.jare.2024.07.024. PubMed PMID:39079584 .