Research
Mouse molecular genetics are used to study the pathogenesis and develop treatment for neurodegenerative diseases
Appointments
- Professor, Psychiatry and Biobehavioral Sciences
Biography
Yang is interested in using the mouse genetic approach to study the pathogenesis and to identify potential therapeutic strategies for neurodegenerative diseases, particularly for Huntington’s Disease (HD) and Parkinson’s Disease (PD).
Yang and his colleagues focus on the following projects:
- in order to understand how mutant Huntington acts to result in a wide variety of clinical symptoms ranging from psychiatric, cognitive to motor deficits, they generate and analyze brain regional-specific models of HD in mice
- they take advantage of the high-speed BAC transgenic system to systematically test candidate dominant genetic modifiers of HD in mice.
- they use BAC transgenesis to introduce known PD mutations into mice to develop mouse models for Parkinson’s Disease
Publications
- Yang, XW, Chen, J, Yang, MQ, Ran, RZ, Gu, HY, Wang, H et al.. Postoperative adjuvant transarterial chemoembolization prolongs overall survival in alpha-fetoprotein-negative hepatocellular carcinoma with bile duct tumor thrombosis: a long-term retrospective cohort study. World J Surg Oncol. 2025;23 (1):260. doi: 10.1186/s12957-025-03917-9. PubMed PMID:40604999 PubMed Central PMC12219712.
- Fu, YG, Huang, YQ, Xu, ZH, Liu, X, Yang, XW. Polyprenylated acylphloroglucinols from Garcinia species and structural revision of seven analogues. Nat Prod Bioprospect. 2025;15 (1):34. doi: 10.1007/s13659-025-00519-6. PubMed PMID:40418352 PubMed Central PMC12106175.
- Li, Y, Zou, ZB, Li, Y, Xie, CL, Zhong, TH, Li, LS et al.. Chemical Constituents of Deep-Sea Derived Fungus Pseudogymnoascus hyalinus and Their Ferroptosis Inhibitory Activity. Chem Biodivers. 2025; :e01289. doi: 10.1002/cbdv.202501289. PubMed PMID:40393429 .
- Wu, TZ, He, ZH, Lin, CY, Li, Y, Zou, ZB, Xie, CL et al.. Dimeric citrinins diversity revealed by the deep-sea-derived Penicillium citrinum W23. Phytochemistry. 2025;237 :114532. doi: 10.1016/j.phytochem.2025.114532. PubMed PMID:40320228 .
- Tang, B, Qu, QC, Cun, DY, Yang, XW, Su, K, Zou, RC et al.. Corrigendum to "WWOX attenuates the progression of gallbladder cancer by suppressing cellular glycolysis through the modulation of the P73/HIF-1a signaling pathway" [Tissue Cell 95 (2025) 102885]. Tissue Cell. 2025; :102926. doi: 10.1016/j.tice.2025.102926. PubMed PMID:40263068 .