Intellectual and Developmental Disabilities Research Center

FACULTY

Yang, Xiangdong William, M.D., Ph.D.

Research

Mouse molecular genetics are used to study the pathogenesis and develop treatment for neurodegenerative diseases

Appointments

  • Professor, Psychiatry and Biobehavioral Sciences

Biography

Yang is interested in using the mouse genetic approach to study the pathogenesis and to identify potential therapeutic strategies for neurodegenerative diseases, particularly for Huntington’s Disease (HD) and Parkinson’s Disease (PD).

Yang and his colleagues focus on the following projects:

  1. in order to understand how mutant Huntington acts to result in a wide variety of clinical symptoms ranging from psychiatric, cognitive to motor deficits, they generate and analyze brain regional-specific models of HD in mice
  2. they take advantage of the high-speed BAC transgenic system to systematically test candidate dominant genetic modifiers of HD in mice.
  3. they use BAC transgenesis to introduce known PD mutations into mice to develop mouse models for Parkinson’s Disease

Publications

  1. Huang, QR, Jiang, Q, Tan, JY, Nong, RB, Yan, J, Yang, XW et al.. The prognostic and immunological role of MCM3 in pan-cancer and validation of prognosis in a clinical lower-grade glioma cohort. Front Pharmacol. 2024;15 :1390615. doi: 10.3389/fphar.2024.1390615. PubMed PMID:38698811 PubMed Central PMC11063780.
  2. Xie, CL, Wu, TZ, Wang, Y, Capon, RJ, Xu, R, Yang, XW et al.. Genome Mining of a Deep-Sea-Derived Penicillium allii-sativi Revealed Polyketide-Terpenoid Hybrids with Antiosteoporosis Activity. Org Lett. 2024;26 (18):3889-3895. doi: 10.1021/acs.orglett.4c01065. PubMed PMID:38668739 .
  3. Marrett, K, Moradi, K, Park, CS, Yan, M, Choi, C, Zhu, M et al.. Gossamer: Scaling Image Processing and Reconstruction to Whole Brains. bioRxiv. 2024; :. doi: 10.1101/2024.04.07.588466. PubMed PMID:38645196 PubMed Central PMC11030332.
  4. Xie, CL, Xiao, HX, Song, PF, Liu, QM, Wei, H, Wu, L et al.. Lead Optimization of Butyrolactone I as an Orally Bioavailable Antiallergic Agent Targeting FcγRIIB. J Med Chem. 2024;67 (9):7504-7515. doi: 10.1021/acs.jmedchem.4c00354. PubMed PMID:38640354 .
  5. Dong, HY, Wang, Y, Zhang, XY, Zhang, M, Yang, LH, Zou, ZB et al.. Chemical Constituents from the deep-sea-derived Fungus Aureobasidium melanogenum LUO5. Chem Biodivers. 2024; :e202400507. doi: 10.1002/cbdv.202400507. PubMed PMID:38606561 .
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