Intellectual and Developmental Disabilities Research Center

FACULTY

Zhang, Ye, Ph.D.

Research

Astrocyte development and the roles of astrocytes in diseases

Appointments

  • Assistant Professor
  • Intellectual and Developmental Disabilities Research Center
  • Semel Institute for Neuroscience and Human Behavior

Biography

Astrocytes constitute at least a third of all cells in human brains. Long thought to be passive support cells, astrocytes are recently found to be critical for the development and function of the central nervous system. Accumulating evidence show that astrocytes are involved in almost every type of neurological and psychiatric disorder.

The cellular and molecular mechanisms that control astrocyte development as well as dysfunction of astrocytes in neurological and psychiatric disorders remains poorly understood.

We combine cell culture and mouse genetic approaches to study the following questions:

  • What signals regulate astrocyte maturation?
  • How is astrocyte differentiation regulated?
  • Can we improve treatment of glioblastoma by studying astrocyte development?
  • Are astrocytes involved in intellectual disability and autism?

Publications

  1. Chai, R, Liu, W, Li, Z, Zhang, Y, Wang, H, Cheng, H et al.. Spatial Information Lasing Enabled by Full-k-Space Bound States in the Continuum. Phys Rev Lett. 2024;132 (18):183801. doi: 10.1103/PhysRevLett.132.183801. PubMed PMID:38759196 .
  2. Ablikim, M, Achasov, MN, Adlarson, P, Ai, XC, Aliberti, R, Amoroso, A et al.. Determination of Spin-Parity Quantum Numbers of X(2370) as 0^{-+} from J/ψ→γK_{S}^{0}K_{S}^{0}η^{'}. Phys Rev Lett. 2024;132 (18):181901. doi: 10.1103/PhysRevLett.132.181901. PubMed PMID:38759175 .
  3. Zhang, T, Zhang, Y, Liu, L, Fang, XX, Zhang, QX, Yuan, X et al.. Experimental Virtual Distillation of Entanglement and Coherence. Phys Rev Lett. 2024;132 (18):180201. doi: 10.1103/PhysRevLett.132.180201. PubMed PMID:38759173 .
  4. Yang, J, Lin, X, Wang, A, Meng, X, Zhao, X, Jing, J et al.. Derivation and Validation of a Scoring System for Predicting Poor Outcome After Posterior Circulation Ischemic Stroke in China. Neurology. 2024;102 (11):e209312. doi: 10.1212/WNL.0000000000209312. PubMed PMID:38759139 .
  5. Guo, X, Ping, J, Yang, Y, Su, X, Shu, XO, Wen, W et al.. Large-scale alternative polyadenylation-wide association studies to identify putative cancer susceptibility genes. Cancer Res. 2024; :. doi: 10.1158/0008-5472.CAN-24-0521. PubMed PMID:38759092 .
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