Zhang, Ye, Ph.D.

Research

Astrocyte development and the roles of astrocytes in diseases

Appointments

• Assistant Professor
• Intellectual and Developmental Disabilities Research Center
• Semel Institute for Neuroscience and Human Behavior

Biography

Astrocytes constitute at least a third of all cells in human brains. Long thought to be passive support cells, astrocytes are recently found to be critical for the development and function of the central nervous system. Accumulating evidence show that astrocytes are involved in almost every type of neurological and psychiatric disorder.

The cellular and molecular mechanisms that control astrocyte development as well as dysfunction of astrocytes in neurological and psychiatric disorders remains poorly understood.

We combine cell culture and mouse genetic approaches to study the following questions:

• What signals regulate astrocyte maturation?
• How is astrocyte differentiation regulated?
• Can we improve treatment of glioblastoma by studying astrocyte development?
• Are astrocytes involved in intellectual disability and autism?

Publications

1. Duan, J, Li, Q, Yin, Z, Zhen, S, Cao, W, Yan, S et al.. Outdoor Artificial Light at Night and Insomnia-Related Social Media Posts. JAMA Netw Open. 2024;7 (11):e2446156. doi: 10.1001/jamanetworkopen.2024.46156. PubMed PMID:39565624 .
2. Zhang, Y, Liu, R, Ma, Y, Jian, N, Ge, H, Pan, H et al.. Surface Selenium Coating Promotes Selective Methanol-to-Formate Electrooxidation on Ni₃Se₄ Nanoparticles. Inorg Chem. 2024; :. doi: 10.1021/acs.inorgchem.4c03996. PubMed PMID:39565610 .
3. Cao, H, Zhang, Y, Zhou, X, Yu, J, Chen, X, Li, L et al.. Boosting the electrochemical performance of the Ni-rich LiNi_0.96Co_0.02Mn_0.02O₂ cathode by high-valence Zr/Mo dual-doping. Chem Commun (Camb). 2024; :. doi: 10.1039/d4cc04275a. PubMed PMID:39565591 .
4. Huang, JX, Liu, FT, Tan, YT, Wang, XY, Huang, JH, Lin, SY et al.. Enhancing detection of high-level axillary lymph node metastasis after neoadjuvant therapy in breast cancer patients with nodal involvement: a combined approach of axilla ultrasound and breast elastography. Radiol Med. 2024; :. doi: 10.1007/s11547-024-01936-2. PubMed PMID:39565571 .
5. Zhu, Y, Wang, S, Chen, Y, Zhang, Y, Feng, Y, Zhang, G et al.. Screened d-p Orbital Hybridization in Turing Structure of Confined Nickel for Sulfion Oxidation Accelerated Hydrogen Production. Angew Chem Int Ed Engl. 2024; :e202419572. doi: 10.1002/anie.202419572. PubMed PMID:39565357 .

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