The Cepeda–Levine laboratory is interested in understanding the functions of the basal ganglia and associated structures, such as the cerebral cortex and thalamus. Our studies focus on how these structures communicate with each other and how their function is altered in models of neurological diseases.

We use a wide array of electrophysiological, behavioral, molecular biological, and imaging techniques to unravel intrinsic neuronal and synaptic dysfunction primarily in genetic mouse models of Huntington’s disease (HD).