Semel Institute of Neuroscience and Human Behavior

Cepeda-Levine lab

Intellectual Development and Disabilities Research Center

Selected Publications

Barry Joshua, Oikonomou Katerina D., Peng Allison, Yu Daniel, Yang Chenyi, Golshani Peyman, Evans Christopher J., Levine Michael S., Cepeda Carlos Dissociable effects of oxycodone on behavior, calcium transient activity, and excitability of dorsolateral striatal neurons. Frontiers in Neural Circuits 16 10/26/2022

Cepeda Carlos, Levinson Simon, Nariai Hiroki, Yazon Vannah-Wila, Tran Conny, Barry Joshua, Oikonomou Katerina D, Vinters Harry V, Fallah Aria, Mathern Gary W, Wu Joyce Y Pathological high frequency oscillations associate with increased GABA synaptic activity in pediatric epilepsy surgery patients. Neurobiology of disease 134 12/9/2019

Donzis Elissa J, Estrada-Sánchez Ana María, Indersmitten Tim, Oikonomou Katerina, Tran Conny H, Wang Catherine, Latifi Shahrzad, Golshani Peyman, Cepeda Carlos, Levine Michael S Cortical Network Dynamics Is Altered in Mouse Models of Huntington’s Disease. Cerebral cortex (New York, N.Y. : 1991) 11/25/2019

Holley Sandra M, Galvan Laurie, Kamdjou Talia, Dong Ashley, Levine Michael S, Cepeda Carlos Major Contribution of Somatostatin-Expressing Interneurons and Cannabinoid Receptors to Increased GABA Synaptic Activity in the Striatum of Huntington’s Disease Mice. Frontiers in synaptic neuroscience 11 11/20/2019

Cepeda Carlos, Oikonomou Katerina D, Cummings Damian, Barry Joshua, Yazon Vannah-Wila, Chen Dickson T, Asai Janelle, Williams Christopher K, Vinters Harry V Developmental origins of cortical hyperexcitability in Huntington’s disease: Review and new observations. Journal of neuroscience research 97 12 10/23/2019

Barry Joshua, Akopian Garnik, Cepeda Carlos, Levine Michael S Striatal Direct and Indirect Pathway Output Structures Are Differentially Altered in Mouse Models of Huntington’s Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience 38 20 10/22/2019

Reidling Jack C, Relaño-Ginés Aroa, Holley Sandra M, Ochaba Joseph, Moore Cindy, Fury Brian, Lau Alice, Tran Andrew H, Yeung Sylvia, Salamati Delaram, Zhu Chunni, Hatami Asa, Cepeda Carlos, Barry Joshua A, Kamdjou Talia, King Alvin, Coleal-Bergum Dane, Franich Nicholas R, LaFerla Frank M, Steffan Joan S, Blurton-Jones Mathew, Meshul Charles K, Bauer Gerhard, Levine Michael S, Chesselet Marie-Francoise, Thompson Leslie M Human Neural Stem Cell Transplantation Rescues Functional Deficits in R6/2 and Q140 Huntington’s Disease Mice. Stem cell reports 10 1 12/26/2018

Holley Sandra M, Kamdjou Talia, Reidling Jack C, Fury Brian, Coleal-Bergum Dane, Bauer Gerhard, Thompson Leslie M, Levine Michael S, Cepeda Carlos Therapeutic effects of stem cells in rodent models of Huntington’s disease: Review and electrophysiological findings. CNS neuroscience & therapeutics 24 4 12/11/2018

Parievsky Anna, Moore Cindy, Kamdjou Talia, Cepeda Carlos, Meshul Charles K, Levine Michael S Differential electrophysiological and morphological alterations of thalamostriatal and corticostriatal projections in the R6/2 mouse model of Huntington’s disease. Neurobiology of disease 108 7/23/2018

Lee Kwang, Holley Sandra M, Shobe Justin L, Chong Natalie C, Cepeda Carlos, Levine Michael S, Masmanidis Sotiris C Parvalbumin Interneurons Modulate Striatal Output and Enhance Performance during Associative Learning. Neuron 93 6 9/29/2017

Chen Jane Y, Tran Conny, Hwang Lin, Deng Gang, Jung Michael E, Faull Kym F, Levine Michael S, Cepeda Carlos Partial Amelioration of Peripheral and Central Symptoms of Huntington’s Disease via Modulation of Lipid Metabolism. Journal of Huntington’s disease 5 1 12/16/2016

Valenza Marta, Chen Jane Y, Di Paolo Eleonora, Ruozi Barbara, Belletti Daniela, Ferrari Bardile Costanza, Leoni Valerio, Caccia Claudio, Brilli Elisa, Di Donato Stefano, Boido Marina M, Vercelli Alessandro, Vandelli Maria A, Forni Flavio, Cepeda Carlos, Levine Michael S, Tosi Giovanni, Cattaneo Elena Cholesterol-loaded nanoparticles ameliorate synaptic and cognitive function in Huntington’s disease mice. EMBO molecular medicine 7 12 6/20/2016

Indersmitten Tim, Tran Conny H, Cepeda Carlos, Levine Michael S Altered excitatory and inhibitory inputs to striatal medium-sized spiny neurons and cortical pyramidal neurons in the Q175 mouse model of Huntington’s disease. Journal of neurophysiology 113 7 12/28/2015

Abdijadid Sara, Mathern Gary W, Levine Michael S, Cepeda Carlos Basic mechanisms of epileptogenesis in pediatric cortical dysplasia. CNS neuroscience & therapeutics 21 2 9/14/2015

Cepeda Carlos, Murphy Kerry P S, Parent Martin, Levine Michael S The role of dopamine in Huntington’s disease. Progress in brain research 211 4/6/2015

Cepeda Carlos, Chen Jane Y, Wu Joyce Y, Fisher Robin S, Vinters Harry V, Mathern Gary W, Levine Michael S Pacemaker GABA synaptic activity may contribute to network synchronization in pediatric cortical dysplasia. Neurobiology of disease 62 9/3/2014

Chen JY, Wang EA, Cepeda C, Levine MS Dopamine imbalance in Huntington’s disease: a mechanism for the lack of behavioral flexibility. Front Neurosci 2013 7

Acuña AI, Esparza M, Kramm C, Beltrán FA, Parra AV, Cepeda C, Toro CA, Vidal RL, Hetz C, Concha II, Brauchi S, Levine MS, Castro MA A failure in energy metabolism and antioxidant uptake precede symptoms of Huntington’s disease in mice. Nat Commun 2013 4

Cepeda C, Galvan L, Holley SM, Rao SP, André VM, Botelho EP, Chen JY, Watson JB, Deisseroth K, Levine MS Multiple sources of striatal inhibition are differentially affected in Huntington’s disease mouse models. J Neurosci 2013 Apr 24 33 17

Raymond LA, André VM, Cepeda C, Gladding CM, Milnerwood AJ, Levine MS Pathophysiology of Huntington’s disease: time-dependent alterations in synaptic and receptor function. Neuroscience 2011 Dec 15 198


André VM, Cepeda C, Fisher YE, Huynh M, Bardakjian N, Singh S, Yang XW, Levine MS Differential electrophysiological changes in striatal output neurons in Huntington’s disease. J Neurosci 2011 Jan 26 31 4